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Substance Abuse Treatment, Prevention, and Policy

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Open Access 01-12-2007 | Research

Deficit of circulating stem – progenitor cells in opiate addiction: a pilot study

Authors: Albert S Reece, Peter Davidson

Published in: Substance Abuse Treatment, Prevention, and Policy | Issue 1/2007

Abstract

A substantial literature describes the capacity of all addictive drugs to slow cell growth and potentiate apoptosis. Flow cytometry was used as a means to compare two lineages of circulating progenitor cells in addicted patients. Buprenorphine treated opiate addicts were compared with medical patients. Peripheral venous blood CD34⁺ CD45⁺ double positive cells were counted as haemopoietic stem cells (HSC's), and CD34⁺ KDR⁺ (VEGFR2⁺) cells were taken as endothelial progenitor cells (EPC's). 10 opiate dependent patients with substance use disorder (SUD) and 11 non-addicted (N-SUD) were studied. The ages were (mean + S.D.) 36.2 + 8.6 and 56.4 + 18.6 respectively (P <0.01). HSC's were not different in the SUD (2.38 + 1.09 Vs. 3.40 + 4.56 cells/mcl). EPC's were however significantly lower in the SUD (0.09 + 0.14 Vs. 0.26 + 0.20 cells/mcl; No. > 0.15, OR = 0.09, 95% C.I. 0.01–0.97), a finding of some interest given the substantially older age of the N-SUD group. These laboratory data are thus consistent with clinical data suggesting accelerated ageing in addicted humans and implicate the important stem cell pool in both addiction toxicology and ageing. They carry important policy implications for understanding the fundamental toxicology of addiction, and suggest that the toxicity both of addiction itself and of indefinite agonist maintenance therapies may have been seriously underestimated.

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Title: Deficit of circulating stem – progenitor cells in opiate addiction: a pilot study
Authors: Albert S Reece
Peter Davidson
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: Substance Abuse Treatment, Prevention, and Policy / Issue 1/2007
Electronic ISSN: 1747-597X
DOI: https://doi.org/10.1186/1747-597X-2-19

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Deficit of circulating stem – progenitor cells in opiate addiction: a pilot study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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