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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 2/2011

01-02-2011 | Original Article

Deep-inspiration breath-hold PET/CT versus free breathing PET/CT and respiratory gating PET for reference: evaluation in 95 patients with lung cancer

Authors: Tsuyoshi Kawano, Eiji Ohtake, Tomio Inoue

Published in: Annals of Nuclear Medicine | Issue 2/2011

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Abstract

Objective

The objective of this study was to define the factors that correlate with differences in maximum standardized uptake value (SUVmax) in deep-inspiration breath-hold (DIBH) and free breathing (FB) PET/CT admixed with respiratory gating (RG) PET for reference.

Methods

Patients (n = 95) with pulmonary lesions were evaluated at one facility over 33 months. After undergoing whole-body PET/CT, a RG PET and FB PET/CT scans were obtained, followed by a DIBH PET/CT scan. All scans were recorded using a list-mode dynamic collection method with respiratory gating. The RG PET was reconstructed using phase gating without attenuation correction; the FB PET was reconstructed from the RG PET sinogram datasets with attenuation correction. Respiratory motion distance, breathing cycle speed, and waveform of RG PET were recorded. The SUVmax of FB PET/CT and DIBH PET/CT were recorded: the percent difference in SUVmax between the FB and DIBH scans was defined as the %BH-index.

Results

The %BH-index was significantly higher for lesions in the lower lung area than in the upper lung area. Respiratory motion distance was significantly higher in the lower lung area than in the upper lung area. A significant relationship was observed between the %BH-index and respiratory motion distance. Waveforms without steady end-expiration tended to show a high %BH-index. Significant inverse relationships were observed between %BH-index and cycle speed, and between respiratory motion distance and cycle speed.

Conclusion

Decrease in SUVmax of FB PET/CT was due to (1) tumor size, (2) distribution of lower lung, (3) long respiratory movement at slow breathing cycle speeds, and (4) respiratory waveforms without steady end-expiration.
Appendix
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Metadata
Title
Deep-inspiration breath-hold PET/CT versus free breathing PET/CT and respiratory gating PET for reference: evaluation in 95 patients with lung cancer
Authors
Tsuyoshi Kawano
Eiji Ohtake
Tomio Inoue
Publication date
01-02-2011
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 2/2011
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-010-0442-2

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