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Published in: Journal of Neural Transmission 7/2008

01-07-2008 | Alzheimer's Disease and Related Disorders - Short Communication

Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment

Authors: R. Ghidoni, L. Benussi, M. Glionna, M. Franzoni, D. Geroldi, E. Emanuele, G. Binetti

Published in: Journal of Neural Transmission | Issue 7/2008

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Abstract

Growing evidence advanced the idea that the soluble form of the receptor for advanced glycation end-products (sRAGE) might serve as a risk marker for several disorders including Alzheimer disease. We found a reduced level of circulating sRAGE in patients with mild cognitive impairment (MCI). The reduction of sRAGE in MCI, as well as the anticipation of the disease in patients with the lowest sRAGE levels (≤225 pg/ml), suggest a role of the RAGE axis in the pathogenesis of the disease.
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Metadata
Title
Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment
Authors
R. Ghidoni
L. Benussi
M. Glionna
M. Franzoni
D. Geroldi
E. Emanuele
G. Binetti
Publication date
01-07-2008
Publisher
Springer Vienna
Published in
Journal of Neural Transmission / Issue 7/2008
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-008-0069-9

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