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01-11-2017 | Nephrology – Original Paper

Decreased percentage of peripheral naïve T cells is independently associated with ischemic stroke in patients on hemodialysis

Authors: Rongyi Chen, Jiachang Hu, Fangfang Xiang, Xiao Tan, Bo Shen, Zhonghua Liu, Wenlv Lv, Xiaoqiang Ding, Xuesen Cao, Jianzhou Zou

Published in: International Urology and Nephrology | Issue 11/2017

Abstract

Purpose

Cerebrovascular complications, including ischemic stroke, account for poor outcomes in patients on hemodialysis. T cell responses may be involved in the pathogenesis of ischemic stroke. We aimed to evaluate the role of naïve T cells in development of ischemic stroke in patients on hemodialysis.

Methods

In this cross-sectional study, 156 patients on hemodialysis in our blood purification center were included. These patients were divided into the ischemic stroke (IS) group (61 cases) and non-ischemic stroke (non-IS) group (95 cases) according to a new diagnosis after initiation of hemodialysis. After being lysed with red blood cell lysis solution, peripheral blood was tested by flow cytometry to detect the expression of CD45RO and CCR7 in CD4 T and CD8 T cells. Correlation analysis and logistic regression analysis were conducted to identify potential independent risk factors for ischemic stroke.

Results

The percentage of peripheral naïve T cells was lower in the IS group [median (interquartile range (IQR)) 13.9% (8.6–22.9%)] compared with the non-IS group [median (IQR) 22.7% (15.9–32.2%), P < 0.001]. Spearman correlation analysis showed that naïve T cells were negatively associated with ischemic stroke (r = −0.308, P < 0.001). Multivariate logistic regression analysis showed that CD4 naïve T cells had an independent negative association with ischemic stroke in patients on hemodialysis (odds ratio 0.933, 95% CI 0.883, 0.986; P = 0.013).

Conclusion

A decrease in percentage of peripheral CD4 naïve T cells is a risk factor for ischemic stroke in patients on hemodialysis.

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Title: Decreased percentage of peripheral naïve T cells is independently associated with ischemic stroke in patients on hemodialysis
Authors: Rongyi Chen
Jiachang Hu
Fangfang Xiang
Xiao Tan
Bo Shen
Zhonghua Liu
Wenlv Lv
Xiaoqiang Ding
Xuesen Cao
Jianzhou Zou
Publication date: 01-11-2017
Publisher: Springer Netherlands
Published in: International Urology and Nephrology / Issue 11/2017
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-017-1691-y

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