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Pediatric Radiology
Published in: Pediatric Radiology 11/2003

01-11-2003 | Case Report

Decreased hepatic uptake of gallium-67 citrate in haemophagocytic syndrome occurring concomitantly with capillary leak syndrome

Authors: Masaaki Morino, Rie Kumakura, Nobuyuki Miura, Nozomu Sasaki

Published in: Pediatric Radiology | Issue 11/2003

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Abstract

We describe a 4-year-old girl with haemophagocytic syndrome (HPS) in whom hepatic gallium-67 citrate (Ga-67) uptake was suppressed when the disease was in its acute phase and returned to normal when the disease was in remission. The prominent clinical feature of this case was the occurrence of systemic capillary leak syndrome (CLS). Because extravasation of plasma proteins may be the result of vascular endothelial injury in CLS, loss of hepatic Ga-67 uptake may reflect insult to the hepatic sinusoidal endothelium. This case suggests a possible role of sinusoidal endothelial cells in the mechanism of hepatic Ga-67 uptake and indicates the need for further study of Ga-67 uptake in patients with HPS.
Literature
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Abe S, Hasegawa S, Nirasawa M, et al (2001) Transferrin is not involved in the entry of 67 Ga into hepatocytes from regenerating liver of partially hepatomized rats. Biol Pharm Bull 24:1343–1346
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Deaciuc IV, Bagby GJ, Lang CH, et al (1993) Hyaluronic acid uptake by the isolated, perfused rat liver: an index of hepatic sinusoidal endothelial cell function. Hepatology 17:266–272PubMed
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Rafi-Janajreh AQ, Chen D, Schmits R, et al (1999) Evidence for the involvement of CD44 in endothelial cell injury and induction of vascular leak syndrome by IL-2. J Immunol 163:1619-1627PubMed
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Metadata
Title
Decreased hepatic uptake of gallium-67 citrate in haemophagocytic syndrome occurring concomitantly with capillary leak syndrome
Authors
Masaaki Morino
Rie Kumakura
Nobuyuki Miura
Nozomu Sasaki
Publication date
01-11-2003
Publisher
Springer-Verlag
Published in
Pediatric Radiology / Issue 11/2003
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-003-1026-2

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