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Surgical Endoscopy

Published in:

01-04-2011

Decrease in sweet taste in rats after gastric bypass surgery

Authors: David S. Tichansky, A. Rebecca Glatt, Atul K. Madan, Jason Harper, Kenichi Tokita, John D. Boughter

Published in: Surgical Endoscopy | Issue 4/2011

Abstract

Background

The literature contains evidence that Roux-en-Y gastric bypass (RYGB) surgery has an effect in humans on taste and preference for carbohydrate-rich foods. This study tested the hypothesis that RYGB affects sweet taste behavior using a rat model.

Methods

Male Sprague–Dawley rats underwent either RYGB or sham surgery. Then 4 weeks after surgery, the rats were given taste-salient, brief-access lick tests with a series of sucrose concentrations.

Results

The RYGB rats, but not the sham rats, lost weight over the 5-week postoperative period. The RYGB rats showed a significant decrease in mean licks for the highest concentration of sucrose (0.25–1.0 mol/l) but not for the low concentrations of sucrose or water.

Conclusions

The findings showed that RYGB surgery affected sweet taste behavior in rats, with postsurgical rats having lower sensitivity or avidity for sucrose than sham-treated control rats. This finding is similar to human reports that sweet taste and preferences for high-caloric foods are altered after bypass surgery.

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Title: Decrease in sweet taste in rats after gastric bypass surgery
Authors: David S. Tichansky
A. Rebecca Glatt
Atul K. Madan
Jason Harper
Kenichi Tokita
John D. Boughter
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: Surgical Endoscopy / Issue 4/2011
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-010-1335-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Decrease in sweet taste in rats after gastric bypass surgery

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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