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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2011

Open Access 01-12-2011 | Case report

De novo acute megakaryoblastic leukemia with p210 BCR/ABL and t(1;16) translocation but not t(9;22) Ph chromosome

Authors: Xiao Min, Zhang Na, Liu Yanan, Li Chunrui

Published in: Journal of Hematology & Oncology | Issue 1/2011

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Abstract

Acute megakaryoblastic leukemia (AMKL) is a type of acute myeloid leukemia (AML), in which majority of the blasts are megakaryoblastic. De novo AMKL in adulthood is rare, and carries very poor prognosis. We here report a 45-year-old woman with de novo AMKL with BCR/ABL rearrangement and der(16)t(1;16)(q21;q23) translocation but negative for t(9;22) Ph chromosome. Upon induction chemotherapy consisting of homoharringtonine, cytarabine and daunorubicin, the patient achieved partial hematological remission. The patient was then switched to imatinib plus one cycle of CAG regimen (low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor), and achieved complete remission (CR). The disease recurred after 40 days and the patient eventually died of infection. To the best of our knowledge, this is the first report of de novo AMKL with p210 BCR/ABL and der(16)t(1;16)(q21;q23) translocation but not t(9;22) Ph chromosome.
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Literature
1.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C: Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). A report of the French-American-British Cooperative Group. Ann Intern Med. 1985, 103: 460-462.CrossRefPubMed
2.
San Miguel JF, Gonzalez M, Cañizo MC, Ojeda E, Orfao A, Caballero MD, Moro MJ, Fisac P, Lopez Borrasca A: Leukemias with megakaryoblastic involvement: clinical, hematologic, and immunologic characteristics. Blood. 1988, 72: 402-407.PubMed
3.
Tallman MS, Neuberg D, Bennett JM, Francois CJ, Paietta E, Wiernik PH, Dewald G, Cassileth PA, Oken MM, Rowe JM: Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience. Blood. 2000, 96: 2405-2411.PubMed
4.
Castoldi GL, Liso V, Fenu S, Vegna ML, Mandelli F: Reproducibility of the morphological diagnostic criteria for acute myeloid leukemia: the GIMEMA group experience. Ann Hematol. 1993, 66: 171-174. 10.1007/BF01703231.CrossRefPubMed
5.
Cuneo A, Ferrant A, Michaux JL, Demuynck H, Boogaerts M, Louwagie A, Doyen C, Stul M, Cassiman JJ, Dal Cin P, Castoldi G, Van den Berghe H: Philadelphia chromosome-positive acute myeloid leukemia: cytoimmunologic and cytogenetic features. Haematologica. 1996, 81: 423-427.PubMed
6.
Buchdunger E, Cioffi CL, Law N, Stover D, Ohno-Jones S, Druker BJ, Lydon NB: Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther. 2000, 295: 139-145.PubMed
7.
Cuneo A, Mecucci C, Kerim S, Vandenberghe E, Dal Cin P, Van Orshoven A, Rodhain J, Bosly A, Michaux JL, Martiat P: Multipotent stem cell involvement in megakaryoblastic leukemia: cytologic and cytogenetic evidence in 15 patients. Blood. 1989, 74: 1781-1790.PubMed
8.
Dastugue N, Lafage-Pochitaloff M, Pagès MP, Radford I, Bastard C, Talmant P, Mozziconacci MJ, Léonard C, Bilhou-Nabéra C, Cabrol C, Capodano AM, Cornillet-Lefebvre P, Lessard M, Mugneret F, Pérot C, Taviaux S, Fenneteaux O, Duchayne E, Berger R, Groupe Français d'Hematologie Cellulaire: Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH). Blood. 2002, 100: 618-626. 10.1182/blood-2001-12-0241.CrossRefPubMed
9.
Ohyashiki K, Ohyashiki JH, Hojo H, Ohtaka M, Toyama K, Sugita K, Nakazawa S, Sugiura K, Nakazawa K, Nagasawa T, Enomoto Y, Watanabe Y: Cytogenetic findings in adult acute leukemia and myeloproliferative disorders with an involvement of megakaryocyte lineage. Cancer. 1990, 65: 940-948. 10.1002/1097-0142(19900215)65:4<940::AID-CNCR2820650420>3.0.CO;2-W.CrossRefPubMed
10.
Saito K, Nakamura Y, Aoyagi M, Waga K, Yamamoto K, Aoyagi A, Inoue F, Nakamura Y, Arai Y, Tadokoro J, Handa T, Tsurumi S, Arai H, Kawagoe Y, Gunnji H, Kitsukawa Y, Takahashi W, Furusawa S: Low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor (CAG regimen) for previously treated patients with relapsed or primary resistant acute myelogenous leukemia (AML) and previously untreated elderly patients with AML, secondary AML, and refractory anemia with excess blasts in transformation. Int J Hematol. 2000, 71: 238-244.PubMed
11.
Pallisgaard N, Hokland P, Riishøj DC, Pedersen B, Jørgensen P: Multiplex reverse transcription-polymerase chain reaction for simultaneous screening of 29 translocations and chromosomal aberrations in acute leukemia. Blood. 1998, 92: 574-588.PubMed
12.
Campiotti L, Grandi AM, Biotti MG, Ultori C, Solbiati F, Codari R, Venco A: Megakaryocytic blast crisis as first presentation of chronic myeloid leukemia. Am J Hematol. 2007, 82: 231-233. 10.1002/ajh.20797.CrossRefPubMed
13.
Pelloso LA, Baiocchi OC, Chauffaille ML, Yamamoto M, Hungria VT, Bordin JO: Megakaryocytic blast crisis as a first presentation of chronic myeloid leukemia. Eur J Haematol. 2002, 69: 58-61. 10.1034/j.1600-0609.2002.01638.x.CrossRefPubMed
14.
Al-Shehri A, Al-Seraihy A, Owaidah TM, Belgaumi AF: Megakaryocytic blast crisis at presentation in a pediatric patient with chronic myeloid leukemia. Hematol Oncol Stem Cell Ther. 2010, 3: 42-46.CrossRefPubMed
15.
Pullarkat ST, Vardiman JW, Slovak ML, Rao DS, Rao NP, Bedell V, Said JW: Megakaryocytic blast crisis as a presenting manifestation of chronic myeloid leukemia. Leuk Res. 2008, 32: 1770-1775. 10.1016/j.leukres.2008.02.025.CrossRefPubMed
16.
Bryant BJ, Alperin JB, Elghetany MT: Paraplegia as the presenting manifestation of extramedullary megakaryoblastic transformation of previously undiagnosed chronic myelogenous leukemia. Am J Hematol. 2007, 82: 150-154. 10.1002/ajh.20777.CrossRefPubMed
17.
Vardiman JW, Harris NL, Brunning RD: The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002, 100: 2292-2302. 10.1182/blood-2002-04-1199.CrossRefPubMed
18.
Peterson LC, Bloomfield CD, Brunning RD: Blast crisis as an initial or terminal manifestation of chronic myeloid leukemia. A study of 28 patients. Am J Med. 1976, 60: 209-220. 10.1016/0002-9343(76)90430-7.CrossRefPubMed
19.
Balatzenko G, Guenova M, Zechev J, Toshkov S: Acute megakaryoblastic leukaemia with extreme thrombocytosis and p190 (bcr/abl) rearrangement. Ann Hematol. 2004, 83: 381-385. 10.1007/s00277-003-0783-1.CrossRefPubMed
20.
Kaloutsi V, Hadjileontis C, Tsatalas C, Sambani C, Kostopoulos I, Papadimitriou C: Occurrence of a variant Philadelphia translocation, t(10;22), in de novo acute megakaryoblastic leukemia. Cancer Genet Cytogenet. 2004, 152: 52-55. 10.1016/j.cancergencyto.2003.08.022.CrossRefPubMed
21.
Corm S, Renneville A, Rad-Quesnel E, Grardel N, Preudhomme C, Quesnel B: Successful treatment of imatinib-resistant acute megakaryoblastic leukemia with e6a2 BCR/ABL: use of dasatinib and reduced-conditioning stem-cell transplantation. Leukemia. 2007, 21: 2376-2377. 10.1038/sj.leu.2404792.CrossRefPubMed
22.
Ahmad F, Dalvi R, Das BR, Mandava S: Novel t(8;17)(q23;q24.2) and t(9;22)(p24.1;q12.2) in acute megakaryoblastic leukemia AML-M7 subtype in an adult patient. Cancer Genet Cytogenet. 2009, 193: 112-115. 10.1016/j.cancergencyto.2009.04.018.CrossRefPubMed
Metadata
Title
De novo acute megakaryoblastic leukemia with p210 BCR/ABL and t(1;16) translocation but not t(9;22) Ph chromosome
Authors
Xiao Min
Zhang Na
Liu Yanan
Li Chunrui
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2011
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/1756-8722-4-45

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