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Published in: Current Atherosclerosis Reports 5/2018

01-05-2018 | Nutrition (P. Kris-Etherton, Section Editor)

Dairy Products, Dairy Fatty Acids, and the Prevention of Cardiometabolic Disease: a Review of Recent Evidence

Authors: Edward Yu, Frank B. Hu

Published in: Current Atherosclerosis Reports | Issue 5/2018

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Abstract

Purpose of Review

To examine recent literature on dairy products, dairy fatty acids, and cardiometabolic disease. Primary questions of interest include what unique challenges researchers face when investigating dairy products/biomarkers, whether one should consume dairy to reduce disease risk, whether dairy fatty acids may be beneficial for health, and whether one should prefer low- or high-fat dairy products.

Recent Findings

Dairy composes about 10% of the calories in a typical American diet, about half of that coming from fluid milk, half coming from cheese, and small amounts from yogurt. Most meta-analyses report no or weak inverse association between dairy intake with cardiovascular disease and related intermediate outcomes. There is some suggestion that dairy consumption was inversely associated with stroke incidence and yogurt consumption was associated with lower risk of type 2 diabetes. Odd chain fatty acids (OCFAs) found primarily in dairy (15:0 and 17:0) appear to be inversely associated with cardiometabolic risk, but causation is uncertain. Substitution analyses based on prospective cohorts suggested that replacing dairy fat with vegetable fat or polyunsaturated fat was associated with significantly lower risk of cardiovascular disease.

Summary

Current evidence suggests null or weak inverse association between consumption of dairy products and risk of cardiovascular disease. However, replacing dairy fat with polyunsaturated fat, especially from plant-based foods, may confer health benefits. More research is needed to examine health effects of different types of dairy products in diverse populations.
Literature
1.
go back to reference Gaucheron F. Milk and dairy products: a unique micronutrient combination. J Am Coll Nutr. 2011;30(5 Suppl 1):400s–9s.PubMedCrossRef Gaucheron F. Milk and dairy products: a unique micronutrient combination. J Am Coll Nutr. 2011;30(5 Suppl 1):400s–9s.PubMedCrossRef
2.
go back to reference Sacks FM, Lichtenstein AH, Wu JHY, Appel LJ, Creager MA, Kris-Etherton PM, et al. Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association. Circulation. 2017;136:e1–e23.PubMedCrossRef Sacks FM, Lichtenstein AH, Wu JHY, Appel LJ, Creager MA, Kris-Etherton PM, et al. Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association. Circulation. 2017;136:e1–e23.PubMedCrossRef
4.
go back to reference Bainbridge ML, Cersosimo LM, Wright A-DG, Kraft J. Content and composition of branched-chain fatty acids in bovine milk are affected by lactation stage and breed of dairy cow. PLoS One. 2016;11(3):e0150386.PubMedPubMedCentralCrossRef Bainbridge ML, Cersosimo LM, Wright A-DG, Kraft J. Content and composition of branched-chain fatty acids in bovine milk are affected by lactation stage and breed of dairy cow. PLoS One. 2016;11(3):e0150386.PubMedPubMedCentralCrossRef
5.
go back to reference SR28 U. National Nutrient Database for Standard Reference, Release 28. US Department of Agriculture, Agricultural Research Service, Nutrient Data Laboratory http://www ars usda gov/ba/bhnrc/ndl Accessed. 2016;26. SR28 U. National Nutrient Database for Standard Reference, Release 28. US Department of Agriculture, Agricultural Research Service, Nutrient Data Laboratory http://​www ars usda gov/ba/bhnrc/ndl Accessed. 2016;26.
6.
go back to reference Stefanov I, Baeten V, Abbas O, Colman E, Vlaeminck B, De Baets B, et al. Analysis of milk odd- and branched-chain fatty acids using Fourier transform (FT)-Raman spectroscopy. J Agric Food Chem. 2010;58(20):10804–11.PubMedCrossRef Stefanov I, Baeten V, Abbas O, Colman E, Vlaeminck B, De Baets B, et al. Analysis of milk odd- and branched-chain fatty acids using Fourier transform (FT)-Raman spectroscopy. J Agric Food Chem. 2010;58(20):10804–11.PubMedCrossRef
7.
go back to reference Lock AL, Bauman DE. Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health. Lipids. 2004;39(12):1197–206.PubMedCrossRef Lock AL, Bauman DE. Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health. Lipids. 2004;39(12):1197–206.PubMedCrossRef
8.
go back to reference O'Donnell-Megaro AM, Barbano DM, Bauman DE. Survey of the fatty acid composition of retail milk in the United States including regional and seasonal variations. J Dairy Sci. 2011;94(1):59–65.PubMedCrossRef O'Donnell-Megaro AM, Barbano DM, Bauman DE. Survey of the fatty acid composition of retail milk in the United States including regional and seasonal variations. J Dairy Sci. 2011;94(1):59–65.PubMedCrossRef
9.
go back to reference Sofie Biong A, Berstad P, Pedersen JI. Biomarkers for intake of dairy fat and dairy products. Eur J Lipid Sci Technol. 2006;108(10):827–34.CrossRef Sofie Biong A, Berstad P, Pedersen JI. Biomarkers for intake of dairy fat and dairy products. Eur J Lipid Sci Technol. 2006;108(10):827–34.CrossRef
10.
go back to reference Horning MG, Martin DB, Karmen A, Vagelos PR. Fatty acid synthesis in adipose tissue. II. Enzymatic synthesis of branched chain and odd-numbered fatty acids. J Biol Chem. 1961;236:669–72.PubMed Horning MG, Martin DB, Karmen A, Vagelos PR. Fatty acid synthesis in adipose tissue. II. Enzymatic synthesis of branched chain and odd-numbered fatty acids. J Biol Chem. 1961;236:669–72.PubMed
11.
go back to reference Tserng KY, Kliegman RM, Miettinen EL, Kalhan SC. A rapid, simple, and sensitive procedure for the determination of free fatty acids in plasma using glass capillary column gas-liquid chromatography. J Lipid Res. 1981;22(5):852–8.PubMed Tserng KY, Kliegman RM, Miettinen EL, Kalhan SC. A rapid, simple, and sensitive procedure for the determination of free fatty acids in plasma using glass capillary column gas-liquid chromatography. J Lipid Res. 1981;22(5):852–8.PubMed
13.
go back to reference Jenkins B, West JA, Koulman A. A review of odd-chain fatty acid metabolism and the role of pentadecanoic acid (c15:0) and heptadecanoic acid (c17:0) in health and disease. Molecules. 2015;20(2):2425–44.PubMedCrossRef Jenkins B, West JA, Koulman A. A review of odd-chain fatty acid metabolism and the role of pentadecanoic acid (c15:0) and heptadecanoic acid (c17:0) in health and disease. Molecules. 2015;20(2):2425–44.PubMedCrossRef
14.
go back to reference National Research Council Committee on Technological Options to Improve the Nutritional Attributes of Animal P. Factors affecting the composition of milk from dairy cows. Designing foods: animal product options in the marketplace. Washington (DC): National Academies Press (US) Copyright (c) 1988 by the National Academy of Sciences.; 1988 National Research Council Committee on Technological Options to Improve the Nutritional Attributes of Animal P. Factors affecting the composition of milk from dairy cows. Designing foods: animal product options in the marketplace. Washington (DC): National Academies Press (US) Copyright (c) 1988 by the National Academy of Sciences.; 1988
15.
go back to reference McGregor RA, Poppitt SD. Milk protein for improved metabolic health: a review of the evidence. Nutr Metab. 2013;10(1):46.CrossRef McGregor RA, Poppitt SD. Milk protein for improved metabolic health: a review of the evidence. Nutr Metab. 2013;10(1):46.CrossRef
16.
go back to reference Jenness R. Biochemical and nutritional aspects of milk and colostrum. Lactation/edited by Bruce L Larson; written by Ralph R Anderson [et al]. 1985. Jenness R. Biochemical and nutritional aspects of milk and colostrum. Lactation/edited by Bruce L Larson; written by Ralph R Anderson [et al]. 1985.
17.
go back to reference Scrimshaw NS, Murray EB. The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance. Am J Clin Nutr. 1988;48(4):1142–59.CrossRef Scrimshaw NS, Murray EB. The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance. Am J Clin Nutr. 1988;48(4):1142–59.CrossRef
18.
go back to reference Willett WC, Reynolds RD, Cottrell-Hoehner S, Sampson L, Browne ML. Validation of a semi-quantitative food frequency questionnaire: comparison with a 1-year diet record. J Am Diet Assoc. 1987;87(1):43–7.PubMed Willett WC, Reynolds RD, Cottrell-Hoehner S, Sampson L, Browne ML. Validation of a semi-quantitative food frequency questionnaire: comparison with a 1-year diet record. J Am Diet Assoc. 1987;87(1):43–7.PubMed
19.
go back to reference Subar AF, Thompson FE, Kipnis V, Midthune D, Hurwitz P, McNutt S, et al. Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires the Eating at America’s Table Study. Am J Epidemiol. 2001;154(12):1089–99.PubMedCrossRef Subar AF, Thompson FE, Kipnis V, Midthune D, Hurwitz P, McNutt S, et al. Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires the Eating at America’s Table Study. Am J Epidemiol. 2001;154(12):1089–99.PubMedCrossRef
20.
go back to reference Byers T, Marshall J, Anthony E, Fiedler R, Zielezny M. The reliability of dietary history from the distant past. Am J Epidemiol. 1987;125(6):999–1011.PubMedCrossRef Byers T, Marshall J, Anthony E, Fiedler R, Zielezny M. The reliability of dietary history from the distant past. Am J Epidemiol. 1987;125(6):999–1011.PubMedCrossRef
21.
go back to reference van Liere MJ, Lucas F, Clavel F, Slimani N, Villeminot S. Relative validity and reproducibility of a French dietary history questionnaire. Int J Epidemiol. 1997;26(Suppl 1):S128–36.PubMedCrossRef van Liere MJ, Lucas F, Clavel F, Slimani N, Villeminot S. Relative validity and reproducibility of a French dietary history questionnaire. Int J Epidemiol. 1997;26(Suppl 1):S128–36.PubMedCrossRef
22.
go back to reference Spain EGo. Relative validity and reproducibility of a diet history questionnaire in Spain. I. Foods. Int J Epidemiol. 1997;26(Suppl 1):S91–9. Spain EGo. Relative validity and reproducibility of a diet history questionnaire in Spain. I. Foods. Int J Epidemiol. 1997;26(Suppl 1):S91–9.
23.
go back to reference Wolk A, Vessby B, Ljung H, Barrefors P. Evaluation of a biological marker of dairy fat intake. Am J Clin Nutr. 1998;68(2):291–5.PubMedCrossRef Wolk A, Vessby B, Ljung H, Barrefors P. Evaluation of a biological marker of dairy fat intake. Am J Clin Nutr. 1998;68(2):291–5.PubMedCrossRef
24.
go back to reference Wolk A, Furuheim M, Vessby B. Fatty acid composition of adipose tissue and serum lipids are valid biological markers of dairy fat intake in men. J Nutr. 2001;131(3):828–33.PubMedCrossRef Wolk A, Furuheim M, Vessby B. Fatty acid composition of adipose tissue and serum lipids are valid biological markers of dairy fat intake in men. J Nutr. 2001;131(3):828–33.PubMedCrossRef
26.
go back to reference Foulon V, Sniekers M, Huysmans E, Asselberghs S, Mahieu V, Mannaerts GP, et al. Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids. J Biol Chem. 2005;280(11):9802–12.PubMedCrossRef Foulon V, Sniekers M, Huysmans E, Asselberghs S, Mahieu V, Mannaerts GP, et al. Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids. J Biol Chem. 2005;280(11):9802–12.PubMedCrossRef
27.
go back to reference Kondo N, Ohno Y, Yamagata M, Obara T, Seki N, Kitamura T, et al. Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids. Nat Commun. 2014;5:5338.PubMedCrossRef Kondo N, Ohno Y, Yamagata M, Obara T, Seki N, Kitamura T, et al. Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids. Nat Commun. 2014;5:5338.PubMedCrossRef
28.
go back to reference Su X, Han X, Yang J, Mancuso DJ, Chen J, Bickel PE, et al. Sequential ordered fatty acid α oxidation and Δ9 desaturation are major determinants of lipid storage and utilization in differentiating adipocytes. Biochemistry. 2004;43(17):5033–44.PubMedCrossRef Su X, Han X, Yang J, Mancuso DJ, Chen J, Bickel PE, et al. Sequential ordered fatty acid α oxidation and Δ9 desaturation are major determinants of lipid storage and utilization in differentiating adipocytes. Biochemistry. 2004;43(17):5033–44.PubMedCrossRef
29.
go back to reference Roberts LD, Virtue S, Vidal-Puig A, Nicholls AW, Griffin JL. Metabolic phenotyping of a model of adipocyte differentiation. Physiol Genomics. 2009;39(2):109–19.PubMedPubMedCentralCrossRef Roberts LD, Virtue S, Vidal-Puig A, Nicholls AW, Griffin JL. Metabolic phenotyping of a model of adipocyte differentiation. Physiol Genomics. 2009;39(2):109–19.PubMedPubMedCentralCrossRef
30.
go back to reference Weitkunat K, Schumann S, Nickel D, Hornemann S, Petzke KJ, Schulze MB, et al. Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate. Am J Clin Nutr. 2017:ajcn152702. Weitkunat K, Schumann S, Nickel D, Hornemann S, Petzke KJ, Schulze MB, et al. Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate. Am J Clin Nutr. 2017:ajcn152702.
31.
go back to reference Health UDo, Services H. 2015–2020 dietary guidelines for Americans. Washington (DC): USDA. 2015. Health UDo, Services H. 2015–2020 dietary guidelines for Americans. Washington (DC): USDA. 2015.
32.
go back to reference Guo J, Astrup A, Lovegrove JA, Gijsbers L, Givens DI, Soedamah-Muthu SS. Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol. 2017;32(4):269–87.PubMedPubMedCentralCrossRef Guo J, Astrup A, Lovegrove JA, Gijsbers L, Givens DI, Soedamah-Muthu SS. Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol. 2017;32(4):269–87.PubMedPubMedCentralCrossRef
33.
go back to reference de Goede J, Soedamah-Muthu SS, Pan A, Gijsbers L, Geleijnse JM. Dairy consumption and risk of stroke: a systematic review and updated dose–response meta-analysis of prospective cohort studies. J Am Heart Assoc: Cardiovasc Cerebrovasc Dis. 2016;5(5):e002787.CrossRef de Goede J, Soedamah-Muthu SS, Pan A, Gijsbers L, Geleijnse JM. Dairy consumption and risk of stroke: a systematic review and updated dose–response meta-analysis of prospective cohort studies. J Am Heart Assoc: Cardiovasc Cerebrovasc Dis. 2016;5(5):e002787.CrossRef
34.
go back to reference Soedamah-Muthu SS, Verberne LD, Ding EL, Engberink MF, Geleijnse JM. Dairy consumption and incidence of hypertension: a dose-response meta-analysis of prospective cohort studies. Hypertension. 2012;60(5):1131–7.PubMedCrossRef Soedamah-Muthu SS, Verberne LD, Ding EL, Engberink MF, Geleijnse JM. Dairy consumption and incidence of hypertension: a dose-response meta-analysis of prospective cohort studies. Hypertension. 2012;60(5):1131–7.PubMedCrossRef
35.
go back to reference Ding M, Huang T, Bergholdt HK, Nordestgaard BG, Ellervik C, Qi L. Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study. BMJ 2017;356. Ding M, Huang T, Bergholdt HK, Nordestgaard BG, Ellervik C, Qi L. Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study. BMJ 2017;356.
36.
go back to reference Kim Y, Je Y. Dairy consumption and risk of metabolic syndrome: a meta-analysis. Diabet Med. 2016;33(4):428–40.PubMedCrossRef Kim Y, Je Y. Dairy consumption and risk of metabolic syndrome: a meta-analysis. Diabet Med. 2016;33(4):428–40.PubMedCrossRef
37.
go back to reference Gijsbers L, Ding EL, Malik VS, de Goede J, Geleijnse JM, Soedamah-Muthu SS. Consumption of dairy foods and diabetes incidence: a dose-response meta-analysis of observational studies. Am J Clin Nutr. 2016;103:1111–24.PubMedCrossRef Gijsbers L, Ding EL, Malik VS, de Goede J, Geleijnse JM, Soedamah-Muthu SS. Consumption of dairy foods and diabetes incidence: a dose-response meta-analysis of observational studies. Am J Clin Nutr. 2016;103:1111–24.PubMedCrossRef
38.
go back to reference Mitri J, Barakatun N, Truong S, ElSayed N, Hamdy O. The effect of dairy consumption on lipid profile: a meta-analysis of randomized controlled trials. J Clin Lipidol. 2017;11(3):825–6.CrossRef Mitri J, Barakatun N, Truong S, ElSayed N, Hamdy O. The effect of dairy consumption on lipid profile: a meta-analysis of randomized controlled trials. J Clin Lipidol. 2017;11(3):825–6.CrossRef
39.
go back to reference Labonté M-È, Couture P, Richard C, Desroches S, Lamarche B. Impact of dairy products on biomarkers of inflammation: a systematic review of randomized controlled nutritional intervention studies in overweight and obese adults. Am J Clin Nutr. 2013;97(4):706–17.PubMedCrossRef Labonté M-È, Couture P, Richard C, Desroches S, Lamarche B. Impact of dairy products on biomarkers of inflammation: a systematic review of randomized controlled nutritional intervention studies in overweight and obese adults. Am J Clin Nutr. 2013;97(4):706–17.PubMedCrossRef
40.
go back to reference Chen GC, Wang Y, Tong X, Szeto IM, Smit G, Li ZN, et al. Cheese consumption and risk of cardiovascular disease: a meta-analysis of prospective studies. Eur J Nutr 2016. Chen GC, Wang Y, Tong X, Szeto IM, Smit G, Li ZN, et al. Cheese consumption and risk of cardiovascular disease: a meta-analysis of prospective studies. Eur J Nutr 2016.
41.
go back to reference Farvid MS, Malekshah AF, Pourshams A, Poustchi H, Sepanlou SG, Sharafkhah M, et al. Dairy food intake and all-cause, cardiovascular disease, and cancer mortality: the Golestan cohort study. Am J Epidemiol. 2017;185(8):697–711.PubMedPubMedCentralCrossRef Farvid MS, Malekshah AF, Pourshams A, Poustchi H, Sepanlou SG, Sharafkhah M, et al. Dairy food intake and all-cause, cardiovascular disease, and cancer mortality: the Golestan cohort study. Am J Epidemiol. 2017;185(8):697–711.PubMedPubMedCentralCrossRef
42.
go back to reference Committee DGA. Scientific report of the 2015 dietary guidelines advisory committee. Washington (DC): USDA and US Department of Health and Human Services; 2015. Committee DGA. Scientific report of the 2015 dietary guidelines advisory committee. Washington (DC): USDA and US Department of Health and Human Services; 2015.
43.
go back to reference Hu FB, Rimm E, Smith-Warner SA, Feskanich D, Stampfer MJ, Ascherio A, et al. Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. Am J Clin Nutr. 1999;69(2):243–9.PubMedCrossRef Hu FB, Rimm E, Smith-Warner SA, Feskanich D, Stampfer MJ, Ascherio A, et al. Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. Am J Clin Nutr. 1999;69(2):243–9.PubMedCrossRef
44.
go back to reference Fung TT, Willett WC, Stampfer MJ, Manson JE, Hu FB. Dietary patterns and the risk of coronary heart disease in women. Arch Intern Med. 2001;161(15):1857–62.PubMedCrossRef Fung TT, Willett WC, Stampfer MJ, Manson JE, Hu FB. Dietary patterns and the risk of coronary heart disease in women. Arch Intern Med. 2001;161(15):1857–62.PubMedCrossRef
45.
go back to reference Hu FB, Rimm EB, Stampfer MJ, Ascherio A, Spiegelman D, Willett WC. Prospective study of major dietary patterns and risk of coronary heart disease in men. Am J Clin Nutr. 2000;72(4):912–21.PubMedCrossRef Hu FB, Rimm EB, Stampfer MJ, Ascherio A, Spiegelman D, Willett WC. Prospective study of major dietary patterns and risk of coronary heart disease in men. Am J Clin Nutr. 2000;72(4):912–21.PubMedCrossRef
46.
go back to reference Kerver JM, Yang EJ, Bianchi L, Song WO. Dietary patterns associated with risk factors for cardiovascular disease in healthy US adults. Am J Clin Nutr. 2003;78(6):1103–10.PubMedCrossRef Kerver JM, Yang EJ, Bianchi L, Song WO. Dietary patterns associated with risk factors for cardiovascular disease in healthy US adults. Am J Clin Nutr. 2003;78(6):1103–10.PubMedCrossRef
47.
go back to reference Saulnier DMA, Spinler JK, Gibson GR, Versalovic J. Mechanisms of probiosis and prebiosis: considerations for enhanced functional foods. Curr Opin Biotechnol. 2009;20(2):135–41.PubMedPubMedCentralCrossRef Saulnier DMA, Spinler JK, Gibson GR, Versalovic J. Mechanisms of probiosis and prebiosis: considerations for enhanced functional foods. Curr Opin Biotechnol. 2009;20(2):135–41.PubMedPubMedCentralCrossRef
48.
go back to reference Chen M, Pan A, Malik VS, Hu FB. Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2012;96(4):735–47.PubMedPubMedCentralCrossRef Chen M, Pan A, Malik VS, Hu FB. Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2012;96(4):735–47.PubMedPubMedCentralCrossRef
49.
go back to reference Heller KJ. Probiotic bacteria in fermented foods: product characteristics and starter organisms1–3. Am J Clin Nutr. 2001;73(2):374s–9s.PubMedCrossRef Heller KJ. Probiotic bacteria in fermented foods: product characteristics and starter organisms1–3. Am J Clin Nutr. 2001;73(2):374s–9s.PubMedCrossRef
50.
go back to reference Plessas S, Bosnea L, Alexopoulos A, Bezirtzoglou E. Potential effects of probiotics in cheese and yogurt production: a review. Engineering in Life Sciences. 2012;12(4):433–40.CrossRef Plessas S, Bosnea L, Alexopoulos A, Bezirtzoglou E. Potential effects of probiotics in cheese and yogurt production: a review. Engineering in Life Sciences. 2012;12(4):433–40.CrossRef
51.
go back to reference Biong AS, Veierod MB, Ringstad J, Thelle DS, Pedersen JI. Intake of milk fat, reflected in adipose tissue fatty acids and risk of myocardial infarction: a case-control study. Eur J Clin Nutr. 2005;60(2):236–44.CrossRef Biong AS, Veierod MB, Ringstad J, Thelle DS, Pedersen JI. Intake of milk fat, reflected in adipose tissue fatty acids and risk of myocardial infarction: a case-control study. Eur J Clin Nutr. 2005;60(2):236–44.CrossRef
52.
go back to reference Goldbohm RA, Chorus AM, Galindo Garre F, Schouten LJ, van den Brandt PA. Dairy consumption and 10-y total and cardiovascular mortality: a prospective cohort study in the Netherlands. Am J Clin Nutr. 2011;93(3):615–27.PubMedCrossRef Goldbohm RA, Chorus AM, Galindo Garre F, Schouten LJ, van den Brandt PA. Dairy consumption and 10-y total and cardiovascular mortality: a prospective cohort study in the Netherlands. Am J Clin Nutr. 2011;93(3):615–27.PubMedCrossRef
53.
go back to reference de Oliveira Otto MC, Mozaffarian D, Kromhout D, Bertoni AG, Sibley CT, Jacobs DR Jr, et al. Dietary intake of saturated fat by food source and incident cardiovascular disease: the multi-ethnic study of atherosclerosis. Am J Clin Nutr. 2012;96(2):397–404.PubMedPubMedCentralCrossRef de Oliveira Otto MC, Mozaffarian D, Kromhout D, Bertoni AG, Sibley CT, Jacobs DR Jr, et al. Dietary intake of saturated fat by food source and incident cardiovascular disease: the multi-ethnic study of atherosclerosis. Am J Clin Nutr. 2012;96(2):397–404.PubMedPubMedCentralCrossRef
54.
go back to reference Chen M, Li Y, Sun Q, Pan A, Manson JE, Rexrode KM, et al. Dairy fat and risk of cardiovascular disease in 3 cohorts of US adults. Am J Clin Nutr. 2016;104:1209–17.PubMedPubMedCentralCrossRef Chen M, Li Y, Sun Q, Pan A, Manson JE, Rexrode KM, et al. Dairy fat and risk of cardiovascular disease in 3 cohorts of US adults. Am J Clin Nutr. 2016;104:1209–17.PubMedPubMedCentralCrossRef
55.
go back to reference Li Y, Hruby A, Bernstein AM, Ley SH, Wang DD, Chiuve SE, et al. Saturated fat as compared with unsaturated fats and sources of carbohydrates in relation to risk of coronary heart disease: a prospective cohort study. J Am Coll Cardiol. 2015;66(14):1538–48.PubMedPubMedCentralCrossRef Li Y, Hruby A, Bernstein AM, Ley SH, Wang DD, Chiuve SE, et al. Saturated fat as compared with unsaturated fats and sources of carbohydrates in relation to risk of coronary heart disease: a prospective cohort study. J Am Coll Cardiol. 2015;66(14):1538–48.PubMedPubMedCentralCrossRef
56.
go back to reference Liang J, Zhou Q, Kwame Amakye W, Su Y, Zhang Z. Biomarkers of dairy fat intake and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies. Crit Rev Food Sci Nutr. 2016:1–9. Liang J, Zhou Q, Kwame Amakye W, Su Y, Zhang Z. Biomarkers of dairy fat intake and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies. Crit Rev Food Sci Nutr. 2016:1–9.
57.
go back to reference Forouhi NG, Koulman A, Sharp SJ, Imamura F, Kröger J, Schulze MB, et al. Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study. Lancet Diabetes Endocrinol. 2014;2(10):810–8.PubMedPubMedCentralCrossRef Forouhi NG, Koulman A, Sharp SJ, Imamura F, Kröger J, Schulze MB, et al. Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study. Lancet Diabetes Endocrinol. 2014;2(10):810–8.PubMedPubMedCentralCrossRef
58.
go back to reference Krachler B, Norberg M, Eriksson JW, Hallmans G, Johansson I, Vessby B, et al. Fatty acid profile of the erythrocyte membrane preceding development of type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis. 2008;18(7):503–10.PubMedCrossRef Krachler B, Norberg M, Eriksson JW, Hallmans G, Johansson I, Vessby B, et al. Fatty acid profile of the erythrocyte membrane preceding development of type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis. 2008;18(7):503–10.PubMedCrossRef
59.
go back to reference Hodge AM, English DR, O'Dea K, Sinclair AJ, Makrides M, Gibson RA, et al. Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. Am J Clin Nutr. 2007;86(1):189–97.PubMedCrossRef Hodge AM, English DR, O'Dea K, Sinclair AJ, Makrides M, Gibson RA, et al. Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. Am J Clin Nutr. 2007;86(1):189–97.PubMedCrossRef
60.
go back to reference Yakoob MY, Shi P, Willett WC, Rexrode KM, Campos H, Orav EJ, et al. Circulating biomarkers of dairy fat and risk of incident diabetes mellitus among men and women in the United States in two large prospective cohorts. Circulation. 2016;133(17):1645–54.PubMedPubMedCentralCrossRef Yakoob MY, Shi P, Willett WC, Rexrode KM, Campos H, Orav EJ, et al. Circulating biomarkers of dairy fat and risk of incident diabetes mellitus among men and women in the United States in two large prospective cohorts. Circulation. 2016;133(17):1645–54.PubMedPubMedCentralCrossRef
61.
go back to reference Santaren ID, Watkins SM, Liese AD, Wagenknecht LE, Rewers MJ, Haffner SM, et al. Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders. Am J Clin Nutr. 2014;100(6):1532–40.PubMedPubMedCentralCrossRef Santaren ID, Watkins SM, Liese AD, Wagenknecht LE, Rewers MJ, Haffner SM, et al. Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders. Am J Clin Nutr. 2014;100(6):1532–40.PubMedPubMedCentralCrossRef
62.
go back to reference Patel PS, Sharp SJ, Jansen E, Luben RN, Khaw K-T, Wareham NJ, et al. Fatty acids measured in plasma and erythrocyte-membrane phospholipids and derived by food-frequency questionnaire and the risk of new-onset type 2 diabetes: a pilot study in the European Prospective Investigation into Cancer and Nutrition (EPIC)–Norfolk cohort. Am J Clin Nutr. 2010;92(5):1214–22.PubMedCrossRef Patel PS, Sharp SJ, Jansen E, Luben RN, Khaw K-T, Wareham NJ, et al. Fatty acids measured in plasma and erythrocyte-membrane phospholipids and derived by food-frequency questionnaire and the risk of new-onset type 2 diabetes: a pilot study in the European Prospective Investigation into Cancer and Nutrition (EPIC)–Norfolk cohort. Am J Clin Nutr. 2010;92(5):1214–22.PubMedCrossRef
63.
go back to reference Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, et al. Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in US adults. Ann Intern Med. 2010;153(12):790–9.PubMedPubMedCentralCrossRef Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, et al. Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in US adults. Ann Intern Med. 2010;153(12):790–9.PubMedPubMedCentralCrossRef
64.
go back to reference Kröger J, Zietemann V, Enzenbach C, Weikert C, Jansen EH, Döring F, et al. Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam Study. Am J Clin Nutr. 2011;93(1):127–42.PubMedCrossRef Kröger J, Zietemann V, Enzenbach C, Weikert C, Jansen EH, Döring F, et al. Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam Study. Am J Clin Nutr. 2011;93(1):127–42.PubMedCrossRef
65.
go back to reference Mozaffarian D, de Oliveira Otto MC, Lemaitre RN, Fretts AM, Hotamisligil G, Tsai MY, et al. Trans-palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the multi-ethnic study of atherosclerosis (MESA). Am J Clin Nutr. 2013;97(4):854–61.PubMedPubMedCentralCrossRef Mozaffarian D, de Oliveira Otto MC, Lemaitre RN, Fretts AM, Hotamisligil G, Tsai MY, et al. Trans-palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the multi-ethnic study of atherosclerosis (MESA). Am J Clin Nutr. 2013;97(4):854–61.PubMedPubMedCentralCrossRef
66.
go back to reference Willett W. Nutritional epidemiology: Oxford University Press; 2012. Willett W. Nutritional epidemiology: Oxford University Press; 2012.
67.
68.
go back to reference Rosell M, Johansson G, Berglund L, Vessby B, de Faire U, Hellenius ML. The relation between alcohol intake and physical activity and the fatty acids 14:0, 15:0 and 17:0 in serum phospholipids and adipose tissue used as markers for dairy fat intake. Br J Nutr. 2005;93(1):115–21.PubMedCrossRef Rosell M, Johansson G, Berglund L, Vessby B, de Faire U, Hellenius ML. The relation between alcohol intake and physical activity and the fatty acids 14:0, 15:0 and 17:0 in serum phospholipids and adipose tissue used as markers for dairy fat intake. Br J Nutr. 2005;93(1):115–21.PubMedCrossRef
69.
go back to reference Jenkins BJ, Seyssel K, Chiu S, Pan P-H, Lin S-Y, Stanley E, et al. Odd chain fatty acids; new insights of the relationship between the gut microbiota, dietary intake, biosynthesis and glucose intolerance. Sci Rep. 2017;7:44845.PubMedPubMedCentralCrossRef Jenkins BJ, Seyssel K, Chiu S, Pan P-H, Lin S-Y, Stanley E, et al. Odd chain fatty acids; new insights of the relationship between the gut microbiota, dietary intake, biosynthesis and glucose intolerance. Sci Rep. 2017;7:44845.PubMedPubMedCentralCrossRef
70.
go back to reference Palmquist DL. Milk fat: origin of fatty acids and influence of nutritional factors thereon. In: Fox PF, McSweeney PLH, editors. Advanced dairy chemistry volume 2 lipids. Boston, MA: Springer US; 2006. p. 43–92.CrossRef Palmquist DL. Milk fat: origin of fatty acids and influence of nutritional factors thereon. In: Fox PF, McSweeney PLH, editors. Advanced dairy chemistry volume 2 lipids. Boston, MA: Springer US; 2006. p. 43–92.CrossRef
71.
go back to reference Huth PJ, Park KM. Influence of dairy product and milk fat consumption on cardiovascular disease risk: a review of the evidence. Adv Nutr: Int Rev J. 2012;3(3):266–85.CrossRef Huth PJ, Park KM. Influence of dairy product and milk fat consumption on cardiovascular disease risk: a review of the evidence. Adv Nutr: Int Rev J. 2012;3(3):266–85.CrossRef
72.
go back to reference Benatar JR, Sidhu K, Stewart RA. Effects of high and low fat dairy food on cardio-metabolic risk factors: a meta-analysis of randomized studies. PLoS One. 2013;8(10):e76480.PubMedPubMedCentralCrossRef Benatar JR, Sidhu K, Stewart RA. Effects of high and low fat dairy food on cardio-metabolic risk factors: a meta-analysis of randomized studies. PLoS One. 2013;8(10):e76480.PubMedPubMedCentralCrossRef
73.
go back to reference Jousilahti P, Laatikainen T, Peltonen M, Borodulin K, Männistö S, Jula A, et al. Primary prevention and risk factor reduction in coronary heart disease mortality among working aged men and women in eastern Finland over 40 years: population based observational study. BMJ. 2016;352 Jousilahti P, Laatikainen T, Peltonen M, Borodulin K, Männistö S, Jula A, et al. Primary prevention and risk factor reduction in coronary heart disease mortality among working aged men and women in eastern Finland over 40 years: population based observational study. BMJ. 2016;352
74.
go back to reference Gao D, Ning N, Wang C, Wang Y, Li Q, Meng Z, et al. Dairy products consumption and risk of type 2 diabetes: systematic review and dose-response Meta-analysis. PLoS One. 2013;8(9):e73965.PubMedPubMedCentralCrossRef Gao D, Ning N, Wang C, Wang Y, Li Q, Meng Z, et al. Dairy products consumption and risk of type 2 diabetes: systematic review and dose-response Meta-analysis. PLoS One. 2013;8(9):e73965.PubMedPubMedCentralCrossRef
75.
go back to reference García Yu IA-L, Sánchez-Aguadero N, Recio-Rodríguez JI. Chapter 25 - Effect of the fat component of dairy products in cardiovascular health, vascular structure and function A2 - Watson, Ronald Ross. In: Collier RJ, Preedy VR, editors. Nutrients in dairy and their implications on health and disease: Academic Press; 2017. p. 325–32. García Yu IA-L, Sánchez-Aguadero N, Recio-Rodríguez JI. Chapter 25 - Effect of the fat component of dairy products in cardiovascular health, vascular structure and function A2 - Watson, Ronald Ross. In: Collier RJ, Preedy VR, editors. Nutrients in dairy and their implications on health and disease: Academic Press; 2017. p. 325–32.
76.
go back to reference Hu FB, Stampfer MJ, Rimm E, Ascherio A, Rosner BA, Spiegelman D, et al. Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. Am J Epidemiol. 1999;149(6):531–40.PubMedCrossRef Hu FB, Stampfer MJ, Rimm E, Ascherio A, Rosner BA, Spiegelman D, et al. Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. Am J Epidemiol. 1999;149(6):531–40.PubMedCrossRef
77.
78.
79.
go back to reference Dugan CE, Barona J, Fernandez ML. Increased dairy consumption differentially improves metabolic syndrome markers in male and female adults. Metab Syndr Relat Disord. 2014;12(1):62–9.PubMedCrossRef Dugan CE, Barona J, Fernandez ML. Increased dairy consumption differentially improves metabolic syndrome markers in male and female adults. Metab Syndr Relat Disord. 2014;12(1):62–9.PubMedCrossRef
80.
go back to reference Wang H, Steffen LM, Vessby B, Basu S, Steinberger J, Moran A, et al. Obesity modifies the relations between serum markers of dairy fats and inflammation and oxidative stress among adolescents. Obesity (Silver Spring). 2011;19(12):2404–10.CrossRef Wang H, Steffen LM, Vessby B, Basu S, Steinberger J, Moran A, et al. Obesity modifies the relations between serum markers of dairy fats and inflammation and oxidative stress among adolescents. Obesity (Silver Spring). 2011;19(12):2404–10.CrossRef
81.
go back to reference Dalmeijer GW, Struijk EA, van der Schouw YT, Soedamah-Muthu SS, Verschuren WMM, Boer JMA, et al. Dairy intake and coronary heart disease or stroke—a population-based cohort study. Int J Cardiol. 2013;167(3):925–9.PubMedCrossRef Dalmeijer GW, Struijk EA, van der Schouw YT, Soedamah-Muthu SS, Verschuren WMM, Boer JMA, et al. Dairy intake and coronary heart disease or stroke—a population-based cohort study. Int J Cardiol. 2013;167(3):925–9.PubMedCrossRef
Metadata
Title
Dairy Products, Dairy Fatty Acids, and the Prevention of Cardiometabolic Disease: a Review of Recent Evidence
Authors
Edward Yu
Frank B. Hu
Publication date
01-05-2018
Publisher
Springer US
Published in
Current Atherosclerosis Reports / Issue 5/2018
Print ISSN: 1523-3804
Electronic ISSN: 1534-6242
DOI
https://doi.org/10.1007/s11883-018-0724-z

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