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Journal of Hepato-Biliary-Pancreatic Sciences

Published in:

01-05-2012 | Original article

d-dimer as a marker of severity in patients with severe acute pancreatitis

Authors: Lu Ke, Hai-bin Ni, Zhi-hui Tong, Wei-qin Li, Ning Li, Jie-shou Li

Published in: Journal of Hepato-Biliary-Pancreatic Sciences | Issue 3/2012

Abstract

Background/purpose

Coagulative disorder is known to occur in the early phase of severe acute pancreatitis (SAP) and d-dimer is a commonly used clinical parameter of hemostasis. The aim of this study was to assess the value of the plasma d-dimer level as a marker of severity in the first 3 days after admission in patients with SAP.

Methods

From January 2009 to February 2011, 45 patients admitted for SAP were included in this observational study. The d-dimer level was measured on a daily basis during days 1–3 after admission and the acute physiology and chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, and other clinical parameters were recorded at the same time. The maximum and the mean d-dimer values were used for analysis and compared with other prognostic factors of SAP.

Results

Both the maximum and mean levels of d-dimer were significantly different between patients with and without clinical variables such as multiple-organ dysfunction syndrome (MODS), need for surgical intervention, and the presence of pancreatic infection. The d-dimer level also showed great precision for the prediction of MODS and secondary infection. Additionally, the d-dimer level correlated well with two usual markers of SAP severity–the APACHE II score and the C-reactive protein level.

Conclusion

d-dimer measurement is a useful, easy, and inexpensive early prognostic marker of the evolution and complications of SAP.

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Title: d-dimer as a marker of severity in patients with severe acute pancreatitis
Authors: Lu Ke
Hai-bin Ni
Zhi-hui Tong
Wei-qin Li
Ning Li
Jie-shou Li
Publication date: 01-05-2012
Publisher: Springer Japan
Published in: Journal of Hepato-Biliary-Pancreatic Sciences / Issue 3/2012
Print ISSN: 1868-6974
Electronic ISSN: 1868-6982
DOI: https://doi.org/10.1007/s00534-011-0414-5

At a glance: The STEP trials

Springer Medicine

d-dimer as a marker of severity in patients with severe acute pancreatitis

Abstract

Background/purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background/purpose

Methods

Results

Conclusion

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