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BMC Cancer
Published in: BMC Cancer 1/2024

Open Access 01-12-2024 | Cytostatic Therapy | Research

Survival outcome of different treatment sequences in patients with locally advanced and metastatic pancreatic cancer

Authors: Mengjiao Fan, Guochao Deng, Yue Ma, Haiyan Si, Zhikuan Wang, Guanghai Dai

Published in: BMC Cancer | Issue 1/2024

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Abstract

Background

Despite some therapeutic advances, improvement in survival rates of unresectable and/or metastatic pancreatic ductal adenocarcinoma (PDAC) has been minimal over recent decade. We aimed to evaluate the impact of different treatment sequences on clinical outcomes of advanced PDAC at our academic institution.

Methods

In this single institution retrospective analysis, we assessed characteristics and survival rates of unresectable and/or metastatic pancreatic PDAC patients who started a systemic treatment between 01/2015 and 12/2021. Survival analyses were performed by Kaplan-Meier and Cox proportional hazards model.

Results

The number of 285 patients received at least two lines of treatment, but only 137 patients were suitable for third-line treatment. Subgroup analysis showed that thirty-seven patients received A line (gemcitabine/nab-paclitaxel or nab-paclitaxel combined therapy to FOLFIRINOX) therapy, 37 patients received B line (nab-paclitaxel combined therapy to gemcitabine combined therapy to FOLFIRINOX) therapy, 21 patients received C line (nab-paclitaxel combined therapy to gemcitabine combined therapy to oxaliplatin or irinotecan combined therapy) therapy. Survival rates for different treatment lines were significantly different and median overall survival (OS) was 14.00, 18.00, and 14.00 months, respectively (p<0.05).

Conclusion

Our study provides real-world evidence for the effectiveness of different treatment sequences and underscores the treatment sequences on survival outcome when considering the entire management in advanced PDAC.
Appendix
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Metadata
Title
Survival outcome of different treatment sequences in patients with locally advanced and metastatic pancreatic cancer
Authors
Mengjiao Fan
Guochao Deng
Yue Ma
Haiyan Si
Zhikuan Wang
Guanghai Dai
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2024
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-024-11823-8

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