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Supportive Care in Cancer

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01-05-2024 | Cytostatic Therapy | Research

Effects of taxane-induced peripheral neuropathy on hand dexterity impairment: evaluation of quantitative and subjective assessments

Authors: Masahiro Manfuku, Junichiro Inoue, Nobuki Yamanaka, Hiroe Kanamori, Kazuhiro Sumiyoshi, Michihiro Osumi

Published in: Supportive Care in Cancer | Issue 5/2024

Abstract

Purpose

Chemotherapy-induced peripheral neuropathy (CIPN) commonly involves hand dexterity impairment. However, the factors affecting hand dexterity impairment are unknown and there is currently no established treatment. The purpose of the current study was to clarify factors influencing hand dexterity impairment in taxane-induced peripheral neuropathy using subjective and objective assessments.

Methods

We assessed patient characteristics, treatment-related factors, subjective symptoms of CIPN (Patient Neurotoxicity Questionnaire [PNQ]), psychological symptoms, and upper limb dysfunction (Quick Disabilities of the Arm, Shoulder and Hand [Quick DASH]). Quantitative assessments were pinch strength, sensory threshold, hand dexterity impairment, and grip force control. Multiple regression analysis was performed using hand dexterity impairment as the dependent variable and age and PNQ, Quick DASH, and control of grip force as independent variables.

Results

Forty-three breast cancer patients were included in the analysis. Hand dexterity impairment in taxane-induced peripheral neuropathy patients was significantly correlated with age, grip force control, and PNQ sensory scores (p < 0.008). Multiple regression analysis demonstrated that PNQ sensory scores and grip force control were significantly associated with hand dexterity impairment (p < 0.01).

Conclusion

Subjective symptoms (numbness and pain) and grip force control contributed to impaired hand dexterity in taxane-induced peripheral neuropathy.

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Title: Effects of taxane-induced peripheral neuropathy on hand dexterity impairment: evaluation of quantitative and subjective assessments
Authors: Masahiro Manfuku
Junichiro Inoue
Nobuki Yamanaka
Hiroe Kanamori
Kazuhiro Sumiyoshi
Michihiro Osumi
Publication date: 01-05-2024
Publisher: Springer Berlin Heidelberg
Keywords: Cytostatic Therapy
Breast Cancer
Breast Cancer
Published in: Supportive Care in Cancer / Issue 5/2024
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-024-08504-4

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