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BMC Neurology
Published in: BMC Neurology 1/2020

Open Access 01-12-2020 | Cytostatic Therapy | Research article

A new approach to characterize postural deficits in chemotherapy-induced peripheral neuropathy and to analyze postural adaptions after an exercise intervention

Authors: Sarah Kneis, Anja Wehrle, Daniela Dalin, Isabella Katharina Wiesmeier, Johann Lambeck, Albert Gollhofer, Hartmut Bertz, Christoph Maurer

Published in: BMC Neurology | Issue 1/2020

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Abstract

Background

Postural instability presents a common and disabling consequence of chemotherapy-induced peripheral neuropathy (CIPN). However, knowledge about postural behavior of CIPN patients is sparse. With this pilot study, we used a new approach to i) characterize postural impairments as compared to healthy subjects, ii) allocate possible abnormalities to a set of parameters describing sensorimotor function, and iii) evaluate the effects of a balance-based exercise intervention.

Methods

We analyzed spontaneous and externally perturbed postural control in eight CIPN patients before and after a balance-based exercise intervention by using a modification of an established postural control model. These findings were compared to 15 matched healthy subjects.

Results

Spontaneous sway amplitude and velocity were larger in CIPN patients compared to healthy subjects. CIPN patients’ reactions to external perturbations were smaller compared to healthy subjects, indicating that patients favor vestibular over proprioceptive sensory information. The balance-based exercise intervention up-weighted proprioceptive information in patients.

Conclusions

CIPN patients’ major postural deficit may relate to underuse of proprioceptive information that results in a less accurate posture control as spontaneous sway results indicate. The balance-based exercise intervention is able to partially correct for this abnormality. Our study contributes to a better understanding of postural impairments in CIPN patients and suggests an effective treatment strategy.

Trial registration

German Clinical Trials Register: DRKS00004340, retrospectively registered 04 January 2013.
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Metadata
Title
A new approach to characterize postural deficits in chemotherapy-induced peripheral neuropathy and to analyze postural adaptions after an exercise intervention
Authors
Sarah Kneis
Anja Wehrle
Daniela Dalin
Isabella Katharina Wiesmeier
Johann Lambeck
Albert Gollhofer
Hartmut Bertz
Christoph Maurer
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2020
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-019-1589-7

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