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Published in: Archives of Dermatological Research 1/2005

01-07-2005 | Original Paper

Cytoplasmic and nuclear expression of survivin in melanocytic skin lesions

Authors: Claudia S. Vetter, Katrin Müller-Blech, David Schrama, Eva-B. Bröcker, Jürgen C. Becker

Published in: Archives of Dermatological Research | Issue 1/2005

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Abstract

Survivin, a member of the inhibitors of apoptosis protein family, regulates both cellular proliferation and apoptotic cell death. While the human survivin gene is highly expressed in the developing fetus, in adults its expression is restricted to highly proliferating normal tissues and neoplastic tumors tissues. In the present study, we compared the expression of survivin in melanoma and benign melanocytic lesions such as junctional, compound, dermal, congenital, blue and spitz nevi. This analysis reveals a heterogeneous expression of survivin with respect to both the intensity, frequency and cellular localization. In junctional, compound and blue nevi, survivin was present in nuclear localization, whereas in spitz nevi survivin was detectable in the cytoplasm. In dermal and congenital nevi, survivin was present in both localizations with predominance of the nuclear compartment. Interestingly, this distribution was similar to that observed in primary melanoma; whereas in metastatic melanoma the predominance of the nuclear localization of survivin was lost. Our data demonstrate that although survivin is expressed in a large number of benign nevi, the balance between its cytoplasmic and nuclear expression was immensely heterogeneous between lesions with suspected different developmental origins.
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Metadata
Title
Cytoplasmic and nuclear expression of survivin in melanocytic skin lesions
Authors
Claudia S. Vetter
Katrin Müller-Blech
David Schrama
Eva-B. Bröcker
Jürgen C. Becker
Publication date
01-07-2005
Publisher
Springer-Verlag
Published in
Archives of Dermatological Research / Issue 1/2005
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-005-0572-x

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