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Journal of Cancer Research and Clinical Oncology
Published in: Journal of Cancer Research and Clinical Oncology 12/2020

01-12-2020 | Cytokines | Review – Cancer Research

The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis

Authors: Marek Samec, Alena Liskova, Lenka Koklesova, Samson Mathews Samuel, Radovan Murin, Pavol Zubor, Jan Bujnak, Taeg Kyu Kwon, Dietrich Büsselberg, Robert Prosecky, Martin Caprnda, Luis Rodrigo, Rachele Ciccocioppo, Peter Kruzliak, Peter Kubatka

Published in: Journal of Cancer Research and Clinical Oncology | Issue 12/2020

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Abstract

The role of immune system in carcinogenesis represents fundamental events associated with cancer eradication; however, tumor evolution is connected with various mechanisms of tumor evasion and progression of cancer. Based on recent evidence, phytochemicals are directly associated with immunomodulation of the innate and adaptive immunity via different mechanisms of action including stimulation and amplification of immune cells, humoral compartments, and associated molecules. This comprehensive study focuses on immunomodulating potential of phytochemicals (mixture in plants or separately such as individual phytochemical) and their impact on regulation of immune response during cancer development, immune tolerance, and immune escape. Clinical application of phytochemicals as modulators of host immunity against cancer may represent perspective approach in anticancer therapy.
Literature
Abdel-Rahman O, Spratlin J, Koski S (2020) Vitamin and herbal supplements’ use among patients with advanced gastrointestinal cancers included in eight clinical trials. J Cancer Res Clin Oncol 146:2089–2097PubMed
Albini A, Bruno A, Noonan DM, Mortara L (2018) Contribution to tumor angiogenesis from innate immune cells within the tumor microenvironment: implications for immunotherapy. Front Immunol 9:527PubMedPubMedCentral
Aravindaram K, Yang NS (2010) Anti-inflammatory plant natural products for cancer therapy. Planta Med 76:1103–1117PubMed
Atri C, Guerfali FZ, Laouini D (2018) Role of human macrophage polarization in inflammation during infectious diseases. Int J Mol Sci 19:1801PubMedCentral
Bachmeier BE, Mohrenz IV, Mirisola V et al (2008) Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. Carcinogenesis 29:779–789
Bally APR, Austin JW, Boss JM (2016) Genetic and epigenetic regulation of PD-1 expression. J Immunol 196:2431–2437PubMed
Bao YX, Wong CK, Leung SF, Chan ATC, Li PW, Wong ELY, Leung PC, Fung KP, Yin YB, Lam CWK (2006) Clinical studies of immunomodulatory activities of Yunzhi-Danshen in patients with nasopharyngeal carcinoma. J Altern Complement Med 12:771–776PubMed
Barrow AD, Edeling MA, Trifonov V, Luo J, Goyal P, Bohl B, Bando JK, Kim AH, Walker J, Andahazy M, Bugatti M, Melocchi L, Vermi W, Fremont DH, Cox S, Cella M, Schmedt C, Colonna M (2018) Natural Killer cells control tumor growth by sensing a growth factor. Cell 172:534–548PubMed
Beatty GL, Gladney WL (2015) Immune escape mechanisms as a guide for cancer immunotherapy. Clin Cancer Res 21:687–692PubMed
Bell RB, Feng Z, Bifulco CB et al (2018) Immunotherapy. In: Oral, head and neck oncology and reconstructive surgery. Elsevier, pp 314–340, ISBN: 9780323265683
Berman AY, Motechin RA, Wiesenfeld MY, Holz MK (2017) The therapeutic potential of resveratrol: a review of clinical trials. NPJ Precis Oncol 1:35PubMedPubMedCentral
Bessler H, Djaldetti M (2017) Capsaicin modulates the immune cross talk between human mononuclears and cells from two colon carcinoma lines. Nutr Cancer 69:14–20PubMed
Bessler H, Djaldetti M (2018) Broccoli and human health: immunomodulatory effect of sulforaphane in a model of colon cancer. Int J Food Sci Nutr 69:946–953PubMed
Boubaker J, Toumia IB, Sassi A, Bzouich-Mokded I, Mazgar SG, Sioud F, Bedoui A, Skhiri SS, Ghedira K, Chekir-Ghedira L (2018) Antitumoral potency by immunomodulation of chloroform extract from leaves of Nitraria retusa, Tunisian medicinal plant, via its major compounds β-sitosterol and palmitic acid in BALB/c mice bearing induced tumor. Nutr Cancer 70:650–662PubMed
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424PubMed
Bruno TC, Ebner PJ, Moore BL, Squalls OG, Waugh KA, Eruslanov EB, Singhal S, Mitchell JD, Franklin WA, Merrick DT, McCarter MD, Palmer BE, Kern JA, Slansky JE (2017) Antigen-presenting intratumoral B cells affect CD4+ TIL phenotypes in non-small cell lung cancer patients. Cancer Immunol Res 5:898–907PubMedPubMedCentral
Calder PC (2013) Feeding the immune system. Proc Nutr Soc 72:299–309PubMed
Candeias S, Gaipl U (2015) The immune system in cancer prevention, development and therapy. Anticancer Agents Med Chem 16:101–107
Cao S, Wylie KM, Wyczalkowski MA, Karpova A, Ley J, Sun S, Mashl RJ, Liang WW, Wang X, Johnson K, DiPersio JF, Gay H, Ratner L, Chen F, Adkins DR, Ding L (2019) Dynamic host immune response in virus-associated cancers. Commun Biol 2:109PubMedPubMedCentral
Carrillo JLM, Rodríguez FPC, Coronado OG, García MAM, Cordero JFC (2017) Physiology and pathology of innate immune response against pathogens. In: Rezaei N (ed) Physiology and pathology of immunology. InTech, Rijeka, pp 275–293
Chaabane F, Mustapha N, Mokdad-Bzeouich I, Sassi A, Kilani-Jaziri S, Franca MGD, Michalet S, Fathallah M, Krifa M, Ghedira K, Chekir-Ghedira L (2016) In vitro and in vivo anti-melanoma effects of Daphne gnidium aqueous extract via activation of the immune system. Tumor Biol 37:6511–6517
Chaudhary B, Elkord E (2016) Regulatory T cells in the tumor microenvironment and cancer progression: role and therapeutic targeting. Vaccines 4:28PubMedCentral
Chen X, Hu ZP, Yang XX, Huang M, Gao Y, Tang W, Chan SY, Dai X, Ye J, Ho PCL, Duan W, Yang HY, Zhu YZ, Zhou SF (2006) Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer. Int Immunopharmacol 6:499–508PubMed
Chen Y, Li H, Zhang G, Wu Y, Xiao J, Liu J, Qiu P, Liu X, Sun L, Du B, Tan Y (2020) Synergistic inhibitory effect of resveratrol and TK/GCV therapy on melanoma cells. J Cancer Res Clin Oncol 146:1489–1499PubMed
Chen QW, Zhu XY, Li YY, Meng ZQ (2014) Epigenetic regulation and cancer (Review). Oncol Rep 31:523–532PubMed
Chiossone L, Dumas PY, Vienne M, Vivier E (2018) Natural killer cells and other innate lymphoid cells in cancer. Nat Rev Immunol 18:671–688PubMed
Coffelt SB, Wellenstein MD, de Visser KE (2016) Neutrophils in cancer: neutral no more. Nat Rev Cancer 16:431–446PubMed
Colegio OR (2018) Skin diseases in the immunosuppressed. InTech, Rijeka
Comen E, Wojnarowicz P, Seshan VE, Shah R, Coker C, Norton L, Benezra R (2016) TNF is a key cytokine mediating neutrophil cytotoxic activity in breast cancer patients. NPJ Breast Cancer 2:16009PubMedPubMedCentral
Dagogo-Jack I, Shaw AT (2018) Tumour heterogeneity and resistance to cancer therapies. Nat Rev Clin Oncol 15:81–94PubMed
Da Silva AB, Cerqueira Coelho PL, Das MNO et al (2020) The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity. Brain Behav Immun 85:170–185PubMed
Dennis KL, Blatner NR, Gounari F, Khazaie K (2013) Current status of IL-10 and regulatory T-cells in cancer. Curr Opin Oncol 25:637–645PubMedPubMedCentral
Dranoff G (2004) Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 4:11–22PubMed
Enesel MB, Acalovschi I, Grosu V, Sbarcea A, Rusu C, Dobre A, Weiss T, Zarkovic N (2005) Perioperative application of the Viscum album extract Isorel in digestive tract cancer patients. Anticancer Res 25:4583–4590PubMed
Gabrilovich DI, Nagaraj S (2009) Myeloid-derived-suppressor cells as regulators of the immune system. Nat Rev Immunol 9:162–174PubMedPubMedCentral
Gagliani N, Huber S (2017) Basic aspects of T helper cell differentiation. In: Lugli E (ed) T-cell differentiation: methods and protocols. Springer, New York, pp 19–30
Gao Y, Zhou S, Jiang W, Huang M, Dai X (2003) Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Investig 2:201–215
Gao Y, Tang W, Dai X, Gao H, Chen G, Ye J, Chan E, Koh HL, Li X, Zhou S (2005) Effects of water-soluble Ganoderma lucidum polysaccharides on the immune functions of patients with advanced lung cancer. J Med Food 8:159–168PubMed
Gaudino SJ, Kumar P (2019) Cross-talk between antigen presenting cells and t cells impacts intestinal homeostasis, bacterial infections, and tumorigenesis. Front Immunol 10:360PubMedPubMedCentral
Golkar L, Ding XZ, Ujiki MB, Salabat MR, Kelly DL, Scholtens D, Fought AJ, Bentrem DJ, Talamonti MS, Bell RH, Adrian TE (2007) Resveratrol inhibits pancreatic cancer cell proliferation through transcriptional induction of macrophage inhibitory cytokine-1. J Surg Res 138:163–169PubMed
Golubnitschaja O, Baban B, Boniolo G, Wang W, Bubnov R, Kapalla M, Krapfenbauer K, Mozaffari MS, Costigliola V (2016) Medicine in the early twenty-first century: paradigm and anticipation—EPMA position paper 2016. EPMA J 7:23PubMedPubMedCentral
Gonzalez H, Hagerling C, Werb Z (2018) Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes Dev 32:1267–1284PubMedPubMedCentral
Gubernatorova EO, Gorshkova EA, Namakanova OA, Zvartsev RA, Hidalgo J, Drutskaya MS, Tumanov AV, Nedospasov SA (2018) Non-redundant functions of IL-6 produced by macrophages and dendritic cells in allergic airway inflammation. Front Immunol 9:2718PubMedPubMedCentral
Guo Q, Jin Z, Yuan Y, Liu R, Xu T, Wei H, Xu X, He S, Chen S, Shi Z, Hou W, Hua B (2016) New mechanisms of tumor-associated macrophages on promoting tumor progression: recent research advances and potential targets for tumor immunotherapy. J Immunol Res 2016:9720912PubMedPubMedCentral
Güran M, Şanlıtürk G, Kerküklü NR, Altundağ EM, Süha Yalçın A (2019) Combined effects of quercetin and curcumin on anti-inflammatory and antimicrobial parameters in vitro. Eur J Pharmacol 859:172486PubMed
He Y, Huang J, Wang P, Shen X, Li S, Yang L, Liu W, Suksamrarn A, Zhang G, Wang F (2016) Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome. Oncotarget 7:4664–4679PubMed
Hoffman W, Lakkis FG, Chalasani G (2016) B cells, antibodies, and more. Clin J Am Soc Nephrol 11:137–154PubMed
Huang AC, Cheng HY, Lin TS, Chen WH, Lin JH, Lin JJ, Lu CC, Chiang JH, Hsu SC, Wu PP, Huang YP, Chung JG (2013) Epigallocatechin gallate (EGCG), influences a murine WEHI-3 leukemia model in vivo through enhancing phagocytosis of macrophages and populations of T- and B-cells. In Vivo 27:627–634PubMed
Igbe I, Shen XF, Jiao W, Qiang Z, Deng T, Li S, Liu WL, Liu HW, Zhang GL, Wang F (2017) Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase. Oncotarget 8:113734–113748PubMedPubMedCentral
Ishikawa H, Saeki T, Otani T, Suzuki T, Shimozuma K, Nishino H, Fukuda S, Morimoto K (2006) Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. J Nutr 136(3 Suppl):816S-S820PubMed
Jang JY, Lee JK, Jeon YK, Kim CW (2013) Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization. BMC Cancer 13:421PubMedPubMedCentral
Jasek K, Kubatka P, Samec M, Liskova A, Smejkal K, Vybohova D, Bugos O, Biskupska-Bodova K, Bielik T, Zubor P, Danko J, Adamkov M, Kwon TK, Büsselberg D (2019) DNA methylation status in cancer disease: modulations by plant-derived natural compounds and dietary interventions. Biomolecules 9:289PubMedCentral
Jenkins SJ, Perona-Wright G, Worsley AGF, Ishii N, MacDonald AS (2007) Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. J Immunol 179:3515–3523PubMed
Johnson SA, Arjmandi BH (2013) Evidence for anti-cancer properties of blueberries: a mini-review. Anticancer Agents Med Chem 13:1142–1148PubMed
Kanaya N, Adams L, Takasaki A, Chen S (2014) Whole blueberry powder inhibits metastasis of triple negative breast cancer in a xenograft mouse model through modulation of inflammatory cytokines. Nutr Cancer 66:242–248PubMed
Kapinova A, Kubatka P, Golubnitschaja O, Kello M, Zubor P, Solar P, Pec M (2018) Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention. Environ Health Prev Med 23:36PubMedPubMedCentral
Kapinova A, Kubatka P, Liskova A, Baranenko D, Kruzliak P, Matta M, Büsselberg D, Malicherova B, Zulli A, Kwon TK, Jezkova E, Blahutova D, Zubor P, Danko J (2019) Controlling metastatic cancer: the role of phytochemicals in cell signaling. J Cancer Res Clin Oncol 145:1087–1109PubMed
Kartikasari AER, Prakash MD, Cox M, Wilson K, Boer JC, Cauchi JA, Plebanski M (2019) Therapeutic cancer vaccines—T cell responses and epigenetic modulation. Front Immunol 9:3109PubMedPubMedCentral
Kiskova T, Demeckova V, Jendzelovska Z, Kiktava M, Venglovska K, Bohmdorfer M, Jager W, Thalhammer T (2017) Nocturnal resveratrol administration inhibits chemically induced breast cancer formation in rats. J Physiol Pharmacol 68:867–875PubMed
Koh YC, Yang G, Lai CS, Weerawatanakorn M, Pan MH (2018) Chemopreventive effects of phytochemicals and medicines on M1/M2 polarized macrophage role in inflammation-related diseases. Int J Mol Sci 19:2208PubMedCentral
Krifa M, Skandrani I, Pizzi A, Nasr N, Ghedira Z, Mustapha N, Ghedira K, Chekir-Ghedira L (2014) An aqueous extract of Limoniastrum guyonianum gall induces anti-tumor effects in melanoma-injected mice via modulation of the immune response. Food Chem Toxicol 69:76–85PubMed
Kristo AS, Klimis-Zacas D, Sikalidis AK (2016) Protective role of dietary berries in cancer. Antioxidants 5:37PubMedCentral
Kumar S, Sharawat SK (2018) Epigenetic regulators of programmed death-ligand 1 expression in human cancers. Transl Res 202:129–145PubMed
Lakshmi Narendra B, Eshvendar Reddy K, Shantikumar S, Ramakrishna S (2013) Immune system: a double-edged sword in cancer. Inflamm Res 62:823–834PubMed
Lechner A, Schlößer HA, Thelen M et al (2019) Tumor-associated B cells and humoral immune response in head and neck squamous cell carcinoma. Oncoimmunology 8:1535293PubMedPubMedCentral
Lee Y, Lee JY (2019) Blackcurrant (Ribes nigrum) extract exerts an anti-inflammatory action by modulating macrophage phenotypes. Nutrients 11:975PubMedCentral
Lee HN, Shin SA, Choo GS, Kim HJ, Park YS, Kim BS, Kim SK, Cho SD, Nam JS, Choi CS, Che JH, Park BK, Jung JY (2018) Anti-inflammatory effect of quercetin and galangin in LPS-stimulated RAW264.7 macrophages and DNCB-induced atopic dermatitis animal models. Int J Mol Med 41:888–898PubMed
Lesjak M, Beara I, Simin N, Pintác D, Majkić T, Bekvalac K, Orčić D, Mimica-Dukić N (2018) Antioxidant and anti-inflammatory activities of quercetin and its derivatives. J Funct Foods 40:68–75
Levina V, Su Y, Nolen B, Liu X, Gordin Y, Lee M, Lokshin A, Gorelik E (2008) Chemotherapeutic drugs and human tumor cells cytokine network. Int J Cancer 123:2031–2040PubMedPubMedCentral
Li H, Chen HY, Liu WX, Jia XX, Zhang JG, Ma CL, Zhang XJ, Yu F, Cong B (2017) Prostaglandin E2 restrains human Treg cell differentiation via E prostanoid receptor 2-protein kinase A signaling. Immunol Lett 191:63–72PubMed
Li B, Severson E, Pignon JC, Zhao H, Li T, Novak J, Jiang P, Shen H, Aster JC, Rodig S, Signoretti S, Liu JS, Liu XS (2016) Comprehensive analyses of tumor immunity: implications for cancer immunotherapy. Genome Biol 17:174PubMedPubMedCentral
Li Q, Hao Z, Hong Y, He W, Zhao W (2018a) Reprogramming tumor associated macrophage phenotype by a polysaccharide from Ilex asprella for sarcoma immunotherapy. Int J Mol Sci 19:3816PubMedCentral
Li Y, Patel SP, Roszik J, Qin Y (2018b) Hypoxia-driven immunosuppressive metabolites in the tumor microenvironment: new approaches for combinational immunotherapy. Front Immunol 9:1591PubMedPubMedCentral
Li M, Spakowicz D, Burkart J, Patel S, Husain M, He K, Bertino EM, Shields PG, Carbone DP, Verschraegen CF, Presley CJ, Otterson GA, Kendra K, Owen DH (2019) Change in neutrophil to lymphocyte ratio during immunotherapy treatment is a non-linear predictor of patient outcomes in advanced cancers. J Cancer Res Clin Oncol 145:2541–2546PubMedPubMedCentral
Liskova A, Kubatka P, Samec M, Zubor P, Mlyncek M, Bielik T, Samuel SM, Zulli A, Kwon TK, Büsselberg D (2019) Dietary phytochemicals targeting cancer stem cells. Molecules 24:899PubMedCentral
Llopiz D, Ruiz M, Silva L, Sarobe P (2018) Enhancement of antitumor vaccination by targeting dendritic cell-related IL-10. Front Immunol 9:1923PubMedPubMedCentral
Maimela NR, Liu S, Zhang Y (2018) Fates of CD8+ T cells in tumor microenvironment. Comput Struct Biotechnol J 17:1–13PubMedPubMedCentral
Manoocheri M, Borhani N, Karbasi A, Koochaki A, Kazemi B (2016) Promoter hypermethylation and downregulation of the FAS gene may be involved in colorectal carcinogenesis. Oncol Lett 12:285–290
Mantovani A, Locati M (2013) Tumor-associated macrophages as a paradigm of macrophage plasticity, diversity, and polarization. Arterioscler Thromb Vasc Biol 33:1478–1483PubMed
Market M, Baxter KE, Angka L, Kennedy MA, Auer RC (2019) The potential for cancer immunotherapy in targeting surgery-induced natural killer cell dysfunction. Cancers (Basel) 11:2
Martin-Blanco N, Blanco R, Alda-Catalinas C, Bovolenta ER, Oeste CL, Palmer E, Schamel WW, Lythe G, Molina-París C, Castro M, Alarcon B (2018) A window of opportunity for cooperativity in the T cell receptor. Nat Commun 9:1–15
Medina KL (2016) Overview of the immune system. Handb Clin Neurol 133:61–76PubMed
Merle NS, Noe R, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, Roumenina LT (2015) Complement system part II: role in immunity. Front Immunol 6:257PubMedPubMedCentral
Miller JS, Lanier LL (2019) Natural killer cells in cancer immunotherapy. Annu Rev Cancer Biol 3:77–103
Mion F, Vetrano S, Tonon S, Valeri V, Piontini A, Burocchi A, Petti L, Frossi B, Gulino A, Tripodo C, Colombo MP, Pucillo CE (2017) Reciprocal influence of B cells and tumor macro and microenvironments in the ApcMin/+ model of colorectal cancer. Oncoimmunology 6:e1336593PubMedPubMedCentral
Nalini D, Selvaraj J, Kumar GS (2020) Herbal nutraceuticals: safe and potent therapeutics to battle tumor hypoxia. J Cancer Res Clin Oncol 146:1–18PubMed
Nowicky JW, Staniszewski A, Zbroja-Sontag W, Slesak B, Nowicky W, Hiesmayr W (1991) Evaluation of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. (“Ukrain”) as an immunostimulant in patients with various carcinomas. Drugs Exp Clin Res 17:139–143PubMed
Olkhanud PB, Damdinsuren B, Bodogai M, Gress RE, Sen R, Wejksza K, Malchinkhuu E, Wersto RP, Biragyn A (2011) Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4+ T cells to T regulatory cells. Cancer Res 71:3505–3515PubMedPubMedCentral
Orecchioni M, Ghosheh Y, Pramod AB, Ley K (2019) Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS–) vs. alternatively activated macrophages. Front Immunol 10:1084PubMedPubMedCentral
Ostuni R, Kratochvill F, Murray PJ, Natoli G (2015) Macrophages and cancer: from mechanisms to therapeutic implications. Trends Immunol 36:229–239PubMed
Paixão EMDS, Oliveira ACM, Pizato N, Muniz-Junqueira MI, Magalhães KG, Nakano EY, Ito MK (2017) The effects of EPA and DHA enriched fish oil on nutritional and immunological markers of treatment naïve breast cancer patients: a randomized double-blind controlled trial. Nutr J 16:71PubMedPubMedCentral
Pan B, Cheng T, Nan KJ, Qiu GQ, Sun XC (2005) Effect of Fuzheng Yiliu decoction combined with chemotherapy on patients with intermediate and late stage gastrointestinal cancer. World J Gastroenterol 11:439–442PubMedPubMedCentral
Pandya PH, Murray ME, Pollok KE, Renbarger JL (2016) The immune system in cancer pathogenesis: potential therapeutic approaches. J Immunol Res 2016:1–13
Paul S, Lal G (2017) The molecular mechanism of natural killer cells function and its importance in cancer immunotherapy. Front Immunol 8:1124PubMedPubMedCentral
Pinho MP, Sundarasetty BS, Bergami-Santos PC, Steponavicius-Cruz K, Ferreira AK, Stripecke R, Barbuto JAM (2016) Dendritic-tumor cell hybrids induce tumor-specific immune responses more effectively than the simple mixture of dendritic and tumor cells. Cytotherapy 18:570–580PubMed
Pongnikorn S, Fongmoon D, Kasinrerk W, Limtrakul PN (2003) Effect of bitter melon (Momordica charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy. J Med Assoc Thai 86:61–68PubMed
Ribatti D (2017) The concept of immune surveillance against tumors: the first theories. Oncotarget 8:7175–7180PubMed
Ruytinx P, Proost P, Van Damme J, Struyf S (2018) Chemokine-induced macrophage polarization in inflammatory conditions. Front Immunol 9:1930PubMedPubMedCentral
Salehi B, Mishra AP, Nigam M, Sener B, Kilic M, Sharifi-Rad M, Fokou PVT, Martins N, Sharifi-Rad J (2018) Resveratrol: a double-edged sword in health benefits. Biomedicines 6:91PubMedCentral
Samec M, Liskova A, Kubatka P et al (2019) The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression. J Cancer Res Clin Oncol 145:1665–1679PubMed
Shapouri-Moghaddam A, Mohammadian S, Vazini H et al (2018) Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol 233:6425–6440PubMed
Shaul ME, Levy L, Sun J et al (2016) Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: a transcriptomics analysis of pro- vs. antitumor TANs. Oncoimmunology 5:e1232221PubMedPubMedCentral
Shen M, Wang J, Ren X (2018) New insights into tumor-infiltrating B lymphocytes in breast cancer: clinical impacts and regulatory mechanisms. Front Immunol 9:470PubMedPubMedCentral
Siracusa MC, Kim BS, Spergel JM, Artis D (2013) Basophils and allergic inflammation. J Allergy Clin Immunol 132:789–801PubMedPubMedCentral
Sodergren MH, Mangal N, Wasan H, Sadanandam A, Balachandran VP, Jiao LR, Habib N (2020) Immunological combination treatment holds the key to improving survival in pancreatic cancer. J Cancer Res Clin Oncol 146:2897–2911PubMedPubMedCentral
Tesone AJ, Rutkowski MR, Brencicova E et al (2016) Satb1 overexpression drives tumor-promoting activities in cancer-associated dendritic cells. Cell Rep 14:1774–1786PubMedPubMedCentral
Thyagarajan A, Sahu RP (2018) Potential contributions of antioxidants to cancer therapy: immunomodulation and radiosensitization. Integr Cancer Ther 17:210–216PubMed
Todoric J, Antonucci L, Karin M (2016) Targeting inflammation in cancer prevention and therapy. Cancer Prev Res (Phila Pa) 9:895–905
Treffers LW, Hiemstra IH, Kuijpers TW, van den Berg TK, Matlung HL (2016) Neutrophils in cancer. Immunol Rev 273:312–328PubMed
Tsou P, Katayama H, Ostrin EJ, Hanash SM (2016) The emerging role of B cells in tumor immunity. Cancer Res 76:5597–5601PubMed
Upadhyay S, Sharma N, Gupta KB, Dhiman M (2018) Role of immune system in tumor progression and carcinogenesis. J Cell Biochem 119:5028–5042PubMed
Uramova S, Kubatka P, Dankova Z et al (2018) Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach. EPMA J 9:403–419PubMedPubMedCentral
Uribe-Querol E, Rosales C (2015) Neutrophils in cancer: two sides of the same coin [Internet]. J Immunol Res 2015:983698PubMedPubMedCentral
Venkatalakshmi P, Vadivel V, Brindha PP (2016) Role of phytochemicals as immunomodulatory agents: a review. Int J Green Pharm 10:1
Vinay DS, Ryan EP, Pawelec G et al (2015) Immune evasion in cancer: Mechanistic basis and therapeutic strategies. Semin Cancer Biol 35(Suppl):S185–S198PubMed
Wang X, Qiu L, Li Z, Wang XY, Yi H (2018) Understanding the multifaceted role of neutrophilsin cancer and autoimmune diseases. Front Immunol 9:2456PubMedPubMedCentral
Wei R, Mao L, Xu P et al (2018) Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models. Food Funct 9:5682–5696PubMedPubMedCentral
Wen T, Rothenberg ME (2016) The regulatory function of eosinophils. Microbiol Spectr 4:10
Wonganan O, He YJ, Shen XF et al (2017) 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. Toxicol Appl Pharmacol 336:31–39PubMed
Wu L, Saxena S, Awaji M, Singh RK (2019) Tumor-associated neutrophils in cancer: going pro. Cancers (Basel) 11:564
Yang JG, Wang WM, Xia HF et al (2019a) Lymphotoxin-α promotes tumor angiogenesis in HNSCC by modulating glycolysis in a PFKFB3-dependent manner. Int J Cancer 145:1358–1370PubMed
Yang G, Zheng RY, Jin ZS (2019b) Correlations between microsatellite instability and the biological behaviour of tumours. J Cancer Res Clin Oncol 145:2891–2899PubMedPubMedCentral
Yin Y, Yao S, Hu Y et al (2017) The immune-microenvironment confers chemoresistance of colorectal cancer through macrophage-derived IL6. Clin Cancer Res 23:7375–7387PubMed
Yue GGL, Li L, Lee JKM et al (2019) Multiple modulatory activities of Andrographis paniculata on immune responses and xenograft growth in esophageal cancer preclinical models. Phytomedicine 60:152886PubMed
Zhao Y, Ge X, Xu X, Yu S, Wang J, Sun L (2019) Prognostic value and clinicopathological roles of phenotypes of tumour-associated macrophages in colorectal cancer. J Cancer Res Clin Oncol 145:3005–3019PubMed
Zhuang SR, Chen SL, Tsai JH et al (2009) Effect of citronellol and the Chinese medical herb complex on cellular immunity of cancer patients receiving chemotherapy/radiotherapy. Phytother Res 23:785–790PubMed
Zhuang SR, Chiu HF, Chen SL et al (2012) Effects of a Chinese medical herbs complex on cellular immunity and toxicity-related conditions of breast cancer patients. Br J Nutr 107:712–718PubMed
Zou JM, Qin J, Li YC et al (2017) IL-35 induces N2 phenotype of neutrophils to promote tumor growth. Oncotarget 8:33501–33514PubMedPubMedCentral
Metadata
Title
The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis
Authors
Marek Samec
Alena Liskova
Lenka Koklesova
Samson Mathews Samuel
Radovan Murin
Pavol Zubor
Jan Bujnak
Taeg Kyu Kwon
Dietrich Büsselberg
Robert Prosecky
Martin Caprnda
Luis Rodrigo
Rachele Ciccocioppo
Peter Kruzliak
Peter Kubatka
Publication date
01-12-2020
Publisher
Springer Berlin Heidelberg
Keyword
Cytokines
Published in
Journal of Cancer Research and Clinical Oncology / Issue 12/2020
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-020-03424-2

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Hyperprogressive disease and its clinical impact in patients with recurrent and/or metastatic head and neck squamous cell carcinoma treated with immune-checkpoint inhibitors: Korean cancer study group HN 18–12

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Implications of flavonoids as potential modulators of cancer neovascularity

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Robotic surgery versus open surgery for thyroid neoplasms: a systematic review and meta-analysis

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Penile cancer: a Brazilian consensus statement for low- and middle-income countries
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