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Published in: World Journal of Pediatrics 7/2022

03-05-2022 | Cytokines | Research Letter

Prevalence of congenital cytomegalovirus infection in preterm, small for gestational age and low birth weight newborns: characteristics and cytokines profile

Authors: Janaina Fortes Lino, Lilian Martins Oliveira Diniz, Débora Marques de Miranda, Daniela Valadão Freitas Rosa, Nathália Gualberto Souza e Silva, Eduardo de Souza Nicolau, Larissa Gonçalves Rezende, Lais Silva Carvalho, Marianna Fischer de Paula Lopes, Luísa Petri Correa, Gabriela Mafra de Oliveira, Flávia Miranda da Silva Alves, Lorena Batista Pascoal, Érika Lima Dolabella Teixeira da Costa, Lêni Márcia Anchieta, Roberta Maia de Castro Romanelli

Published in: World Journal of Pediatrics | Issue 7/2022

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Excerpt

Cytomegalovirus is the most frequent agent of congenital viral infections, affecting approximately 0.2%–2.4% of live births in different countries [17]. Universal screening for congenital cytomegalovirus infection in newborns is not a standard practice considering cost–benefit issues and viability of diagnostic tests. Besides, most newborns are asymptomatic and there is no effective treatment for this population [25]. …
Literature
1.
go back to reference Neu N, Duchon J, Zachariah P. TORCH infections. Clin Perinatol. 2015;42:77–103, viii.CrossRef Neu N, Duchon J, Zachariah P. TORCH infections. Clin Perinatol. 2015;42:77–103, viii.CrossRef
2.
go back to reference Balcells C, Botet F, Gayete S, Marcos M, Dorronsoro I, de Alba C, et al. Vertically transmitted cytomegalovirus infection in newborn preterm infants. J Perinat Med. 2016;44:485–90.CrossRef Balcells C, Botet F, Gayete S, Marcos M, Dorronsoro I, de Alba C, et al. Vertically transmitted cytomegalovirus infection in newborn preterm infants. J Perinat Med. 2016;44:485–90.CrossRef
3.
go back to reference Lorenzoni F, Lunardi S, Liumbruno A, Ferri G, Madrigali V, Fiorentini E, et al. Neonatal screening for congenital cytomegalovirus infection in preterm and small for gestational age infants. J Matern Fetal Neonatal Med. 2014;27:1589–93.CrossRef Lorenzoni F, Lunardi S, Liumbruno A, Ferri G, Madrigali V, Fiorentini E, et al. Neonatal screening for congenital cytomegalovirus infection in preterm and small for gestational age infants. J Matern Fetal Neonatal Med. 2014;27:1589–93.CrossRef
4.
go back to reference Espiritu MM, Bailey S, Wachtel EV, Mally PV. Utility of routine urine CMV PCR and total serum IgM testing of small for gestational age infants: a single center review. J Perinat Med. 2018;46:81–6.CrossRef Espiritu MM, Bailey S, Wachtel EV, Mally PV. Utility of routine urine CMV PCR and total serum IgM testing of small for gestational age infants: a single center review. J Perinat Med. 2018;46:81–6.CrossRef
5.
go back to reference Yamamoto AY, Mussi-Pinhata MM, Cristina P, Pinto G, MoraesFigueiredo LT, Jorge SM. Congenital cytomegalovirus infection in preterm and full-term newborn infants from a population with a high seroprevalence rate. Pediatr Infect Dis J. 2001;20:188–92.CrossRef Yamamoto AY, Mussi-Pinhata MM, Cristina P, Pinto G, MoraesFigueiredo LT, Jorge SM. Congenital cytomegalovirus infection in preterm and full-term newborn infants from a population with a high seroprevalence rate. Pediatr Infect Dis J. 2001;20:188–92.CrossRef
6.
go back to reference Yamamoto AY, Castellucci RA, Aragon DC, Mussi-Pinhata MM. Early high CMV seroprevalence in pregnant women from a population with a high rate of congenital infection. Epidemiol Infect. 2013;141:2187–91.CrossRef Yamamoto AY, Castellucci RA, Aragon DC, Mussi-Pinhata MM. Early high CMV seroprevalence in pregnant women from a population with a high rate of congenital infection. Epidemiol Infect. 2013;141:2187–91.CrossRef
7.
go back to reference Turner KM, Lee HC, Boppana SB, Carlo WA, Randolph DA. Incidence and impact of CMV infection in very low birth weight infants. Pediatrics. 2014;133:e609–15.CrossRef Turner KM, Lee HC, Boppana SB, Carlo WA, Randolph DA. Incidence and impact of CMV infection in very low birth weight infants. Pediatrics. 2014;133:e609–15.CrossRef
8.
go back to reference ÁlvarezDomínguez E, FiguerasAloy J, BotetMussons F, Marcos Maeso MA, Pérez Fernández JM. Screening for cytomegalovirus infection in very low birth weight infants. An Pediatr (Barc). 2013;79:3–9.CrossRef ÁlvarezDomínguez E, FiguerasAloy J, BotetMussons F, Marcos Maeso MA, Pérez Fernández JM. Screening for cytomegalovirus infection in very low birth weight infants. An Pediatr (Barc). 2013;79:3–9.CrossRef
9.
go back to reference Vaudry W, Rosychuk RJ, Lee BE, Cheung PY, Pang X, Preiksaitis JK. Congenital cytomegalovirus infection in high-risk Canadian infants: Report of a pilot screening study. Can J Infect Dis Med Microbiol. 2010;21:e12–9.CrossRef Vaudry W, Rosychuk RJ, Lee BE, Cheung PY, Pang X, Preiksaitis JK. Congenital cytomegalovirus infection in high-risk Canadian infants: Report of a pilot screening study. Can J Infect Dis Med Microbiol. 2010;21:e12–9.CrossRef
10.
go back to reference Panhani S, Heinonen KM. Screening for congenital cytomegalovirus infection among preterm infants born before the 34th gestational week in Finland. Scand J Infect Dis. 1994;26:375–8.CrossRef Panhani S, Heinonen KM. Screening for congenital cytomegalovirus infection among preterm infants born before the 34th gestational week in Finland. Scand J Infect Dis. 1994;26:375–8.CrossRef
11.
go back to reference Pass RF, Stagno S, Britt WJ, Alford CA. Specific cell-mediated immunity and the natural history of congenital infection with cytomegalovirus. J Infect Dis. 1983;148:953–61.CrossRef Pass RF, Stagno S, Britt WJ, Alford CA. Specific cell-mediated immunity and the natural history of congenital infection with cytomegalovirus. J Infect Dis. 1983;148:953–61.CrossRef
12.
go back to reference Noyola DE, Demmler GJ, Williamson WD, Griesser C, Sellers S, Llorente A, et al. Cytomegalovirus urinary excretion and long-term outcome in children with congenital cytomegalovirus infection. Congenital CMV Longitudinal Study Group. Pediatr Infect Dis J. 2000;19:505–10.CrossRef Noyola DE, Demmler GJ, Williamson WD, Griesser C, Sellers S, Llorente A, et al. Cytomegalovirus urinary excretion and long-term outcome in children with congenital cytomegalovirus infection. Congenital CMV Longitudinal Study Group. Pediatr Infect Dis J. 2000;19:505–10.CrossRef
13.
go back to reference Lanari M, Lazzarotto T, Venturi V, Papa I, Gabrielli L, Guerra B, et al. Neonatal cytomegalovirus blood load and risk of sequelae in symptomatic and asymptomatic congenitally infected newborns. Pediatrics. 2006;117:e76-83.CrossRef Lanari M, Lazzarotto T, Venturi V, Papa I, Gabrielli L, Guerra B, et al. Neonatal cytomegalovirus blood load and risk of sequelae in symptomatic and asymptomatic congenitally infected newborns. Pediatrics. 2006;117:e76-83.CrossRef
14.
go back to reference WHO Expert Committee on Physical Status: The Use and Interpretation of Anthropometry. Physical status: the use and interpretation of anthropometry: report of a WHO Expert Committee. Geneva: World Health Organization; 1995, p 452 WHO Expert Committee on Physical Status: The Use and Interpretation of Anthropometry. Physical status: the use and interpretation of anthropometry: report of a WHO Expert Committee. Geneva: World Health Organization; 1995, p 452
15.
go back to reference World Health Organization. International statistical classification of diseases and related health problems. 10th revision, 2nd edition. ed. Geneva: World Health Organization; 2004. World Health Organization. International statistical classification of diseases and related health problems. 10th revision, 2nd edition. ed. Geneva: World Health Organization; 2004.
17.
go back to reference Oliveira GM, Pascoal-Xavier MA, Moreira DR, Guimarães VS, Aguiar RALP, Miranda DM, et al. Detection of cytomegalovirus, herpes virus simplex, and parvovirus b19 in spontaneous abortion placentas. J Matern Fetal Neonatal Med. 2019;32:768–75.CrossRef Oliveira GM, Pascoal-Xavier MA, Moreira DR, Guimarães VS, Aguiar RALP, Miranda DM, et al. Detection of cytomegalovirus, herpes virus simplex, and parvovirus b19 in spontaneous abortion placentas. J Matern Fetal Neonatal Med. 2019;32:768–75.CrossRef
19.
go back to reference McIver CJ, Jacques CF, Chow SS, Munro SC, Scott GM, Roberts JA, et al. Development of multiplex PCRs for detection of common viral pathogens and agents of congenital infections. J Clin Microbiol. 2005;43:5102–10.CrossRef McIver CJ, Jacques CF, Chow SS, Munro SC, Scott GM, Roberts JA, et al. Development of multiplex PCRs for detection of common viral pathogens and agents of congenital infections. J Clin Microbiol. 2005;43:5102–10.CrossRef
20.
go back to reference Santos DV, Souza MM, Gonçalves SH, Cotta AC, Melo LA, Andrade GM, et al. Congenital cytomegalovirus infection in a neonatal intensive care unit in Brazil evaluated by PCR and association with perinatal aspects. Rev Inst Med Trop Sao Paulo. 2000;42:129–32.CrossRef Santos DV, Souza MM, Gonçalves SH, Cotta AC, Melo LA, Andrade GM, et al. Congenital cytomegalovirus infection in a neonatal intensive care unit in Brazil evaluated by PCR and association with perinatal aspects. Rev Inst Med Trop Sao Paulo. 2000;42:129–32.CrossRef
21.
go back to reference Marsico C, Aban I, Kuo H, James SH, Sanchez PJ, Ahmed A, et al. Blood viral load in symptomatic congenital cytomegalovirus infection. J Infect Dis. 2019;219:1398–406.CrossRef Marsico C, Aban I, Kuo H, James SH, Sanchez PJ, Ahmed A, et al. Blood viral load in symptomatic congenital cytomegalovirus infection. J Infect Dis. 2019;219:1398–406.CrossRef
22.
go back to reference Nelson CT, Istas AS, Wilkerson MK, Demmler GJ. PCR detection of cytomegalovirus DNA in serum as a diagnostic test for congenital cytomegalovirus infection. J Clin Microbiol. 1995;33:3317–8.CrossRef Nelson CT, Istas AS, Wilkerson MK, Demmler GJ. PCR detection of cytomegalovirus DNA in serum as a diagnostic test for congenital cytomegalovirus infection. J Clin Microbiol. 1995;33:3317–8.CrossRef
23.
go back to reference Ross SA, Ahmed A, Palmer AL, Michaels MG, Sánchez PJ, Stewart A, et al. Urine collection method for the diagnosis of congenital cytomegalovirus infection. Pediatr Infect Dis J. 2015;34:903–5.CrossRef Ross SA, Ahmed A, Palmer AL, Michaels MG, Sánchez PJ, Stewart A, et al. Urine collection method for the diagnosis of congenital cytomegalovirus infection. Pediatr Infect Dis J. 2015;34:903–5.CrossRef
24.
go back to reference Koyano S, Inoue N, Oka A, Moriuchi H, Asano K, Ito Y, et al. Screening for congenital cytomegalovirus infection using newborn urine samples collected on filter paper: feasibility and outcomes from a multicentre study. BMJ Open. 2011;1:e000118.CrossRef Koyano S, Inoue N, Oka A, Moriuchi H, Asano K, Ito Y, et al. Screening for congenital cytomegalovirus infection using newborn urine samples collected on filter paper: feasibility and outcomes from a multicentre study. BMJ Open. 2011;1:e000118.CrossRef
25.
go back to reference Mussi-Pinhata MM, Yamamoto AY, Aragon DC, Duarte G, Fowler KB, Boppana S, et al. Seroconversion for cytomegalovirus infection during pregnancy and fetal infection in a highly seropositive population: “The BraCHS Study.” J Infect Dis. 2018;218:1200–4.CrossRef Mussi-Pinhata MM, Yamamoto AY, Aragon DC, Duarte G, Fowler KB, Boppana S, et al. Seroconversion for cytomegalovirus infection during pregnancy and fetal infection in a highly seropositive population: “The BraCHS Study.” J Infect Dis. 2018;218:1200–4.CrossRef
26.
go back to reference Vries JJ, van Zwet EW, Dekker FW, Kroes AC, Verkerk PH, Vossen AC. The apparent paradox of maternal seropositivity as a risk factor for congenital cytomegalovirus infection: a population-based prediction model. Rev Med Virol. 2013;23:241–9.CrossRef Vries JJ, van Zwet EW, Dekker FW, Kroes AC, Verkerk PH, Vossen AC. The apparent paradox of maternal seropositivity as a risk factor for congenital cytomegalovirus infection: a population-based prediction model. Rev Med Virol. 2013;23:241–9.CrossRef
27.
go back to reference Mussi-Pinhata MM, Yamamoto AY. Natural history of congenital cytomegalovirus infection in highly seropositive populations. J Infect Dis. 2020;221(Suppl 1):S15–22.CrossRef Mussi-Pinhata MM, Yamamoto AY. Natural history of congenital cytomegalovirus infection in highly seropositive populations. J Infect Dis. 2020;221(Suppl 1):S15–22.CrossRef
28.
go back to reference Lausman A, Kingdom J, COMMITTEE MFM. Intrauterine growth restriction: screening, diagnosis, and management. J Obstet Gynaecol Can. 2013;35:741–8.CrossRef Lausman A, Kingdom J, COMMITTEE MFM. Intrauterine growth restriction: screening, diagnosis, and management. J Obstet Gynaecol Can. 2013;35:741–8.CrossRef
29.
go back to reference Luck SE, Wieringa JW, Blázquez-Gamero D, Henneke P, Schuster K, Butler K, et al. Congenital cytomegalovirus: a European expert consensus statement on diagnosis and management. Pediatr Infect Dis J. 2017;36:1205–13.CrossRef Luck SE, Wieringa JW, Blázquez-Gamero D, Henneke P, Schuster K, Butler K, et al. Congenital cytomegalovirus: a European expert consensus statement on diagnosis and management. Pediatr Infect Dis J. 2017;36:1205–13.CrossRef
30.
go back to reference Chen Y, Qian J. Increased serum levels of IL-33 and soluble ST2 in neonates with human cytomegalovirus infection. J Med Virol. 2018;90:1383–8.CrossRef Chen Y, Qian J. Increased serum levels of IL-33 and soluble ST2 in neonates with human cytomegalovirus infection. J Med Virol. 2018;90:1383–8.CrossRef
31.
go back to reference Numazaki K, Fujikawa T, Asanuma H. Immunological evaluation and clinical aspects of children with congenital cytomegalovirus infection. Congenit Anom (Kyoto). 2002;42:181–6.CrossRef Numazaki K, Fujikawa T, Asanuma H. Immunological evaluation and clinical aspects of children with congenital cytomegalovirus infection. Congenit Anom (Kyoto). 2002;42:181–6.CrossRef
32.
go back to reference Jung E, Romero R, Yeo L, Diaz-Primera R, Marin-Concha J, Para R, et al. The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis and obstetric implications. Semin Fetal Neonatal Med. 2020;25:101146.CrossRef Jung E, Romero R, Yeo L, Diaz-Primera R, Marin-Concha J, Para R, et al. The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis and obstetric implications. Semin Fetal Neonatal Med. 2020;25:101146.CrossRef
33.
go back to reference Ross SA, Kimberlin D. Clinical outcome and the role of antivirals in congenital cytomegalovirus infection. Antiviral Res. 2021;1901:105083.CrossRef Ross SA, Kimberlin D. Clinical outcome and the role of antivirals in congenital cytomegalovirus infection. Antiviral Res. 2021;1901:105083.CrossRef
Metadata
Title
Prevalence of congenital cytomegalovirus infection in preterm, small for gestational age and low birth weight newborns: characteristics and cytokines profile
Authors
Janaina Fortes Lino
Lilian Martins Oliveira Diniz
Débora Marques de Miranda
Daniela Valadão Freitas Rosa
Nathália Gualberto Souza e Silva
Eduardo de Souza Nicolau
Larissa Gonçalves Rezende
Lais Silva Carvalho
Marianna Fischer de Paula Lopes
Luísa Petri Correa
Gabriela Mafra de Oliveira
Flávia Miranda da Silva Alves
Lorena Batista Pascoal
Érika Lima Dolabella Teixeira da Costa
Lêni Márcia Anchieta
Roberta Maia de Castro Romanelli
Publication date
03-05-2022
Publisher
Springer Nature Singapore
Published in
World Journal of Pediatrics / Issue 7/2022
Print ISSN: 1708-8569
Electronic ISSN: 1867-0687
DOI
https://doi.org/10.1007/s12519-022-00551-3

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