Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
European Journal of Clinical Microbiology & Infectious Diseases
Published in: European Journal of Clinical Microbiology & Infectious Diseases 1/2011

Open Access 01-01-2011 | Brief Report

Cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection

Authors: T. Takano, H. Tajiri, Y. Kashiwagi, S. Kimura, H. Kawashima

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 1/2011

Login to get access

Abstract

We report the systemic cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection. In patients with pneumonia, the serum levels of IFN-γ and IL-5 were significantly higher than those in patients without pneumonia. This tendency was also present for IL-6, IL-8, IL-10, IL-13, and MCP-1 in patients with pneumonia. Among patients with pneumonia, the levels of MCP-1 were significantly higher in the group of patients with pneumonia with severe respiratory failure than patients with mild pneumonia.
Literature
1.
Khan K, Arino J, Hu W et al (2009) Spread of a novel influenza A (H1N1) virus via global airline transportation. N Engl J Med 361:212–214CrossRefPubMed
2.
Perez-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S et al (2009) Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med 361:680–689CrossRefPubMed
3.
Kawada J, Kimura H, Ito Y et al (2003) Systemic cytokine responses in patients with influenza-associated encephalopathy. J Infect Dis 188:690–698CrossRefPubMed
4.
Hosoya M, Nunoi H, Aoyama M et al (2005) Cytochrome c and tumor necrosis factor-alpha values in serum and cerebrospinal fluid of patients with influenza-associated encephalopathy. Pediatr Infect Dis J 24:467–470CrossRefPubMed
5.
de Jong MD, Simmons CP, Thanh TT et al (2006) Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med 12:1203–1207CrossRefPubMed
6.
Dessing MC, van der Sluijs KF, Florquin S, van der Poll T (2007) Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia. Clin Immunol 125:328–336CrossRefPubMed
7.
Wu W, Booth JL, Duggan ES et al (2010) Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model. Virology 396:178–188CrossRefPubMed
8.
Van Reeth K, Nauwynck H, Pensaert M (1998) Bronchoalveolar interferon-alpha, tumor necrosis factor-alpha, interleukin-1, and inflammation during acute influenza in pigs: a possible model for humans? J Infect Dis 177:1076–1079CrossRefPubMed
9.
Morishima T, Togashi T, Yokota S et al; Collaborative Study Group on Influenza-Associated Encephalopathy in Japan (2002) Encephalitis and encephalopathy associated with an influenza epidemic in Japan. Clin Infect Dis 35:512–517CrossRefPubMed
Metadata
Title
Cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection
Authors
T. Takano
H. Tajiri
Y. Kashiwagi
S. Kimura
H. Kawashima
Publication date
01-01-2011
Publisher
Springer-Verlag
Published in
European Journal of Clinical Microbiology & Infectious Diseases / Issue 1/2011
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-010-1041-9

Other articles of this Issue 1/2011

European Journal of Clinical Microbiology & Infectious Diseases 1/2011 Go to the issue

Article

Effect of statins on outcomes in immunosuppressed patients with bloodstream infection

Brief Report

Clinical characteristics and outcomes of patients with vancomycin-susceptible Enterococcus faecalis and Enterococcus faecium bacteraemia in cancer patients

Article

Cytomegalovirus seroprevalence in exposed and unexposed populations of hospital employees

Article

Improvement of attention span and reaction time with hyperbaric oxygen treatment in patients with toxic injury due to mold exposure

Article

Clinical and molecular epidemiology of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a long-term study from Japan

Article

Treatment with peginterferon versus interferon in Chinese patients with chronic hepatitis C
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits