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Tumor Biology
Published in: Tumor Biology 7/2014

01-07-2014 | Review

Cytoglobin in tumor hypoxia: novel insights into cancer suppression

Authors: Sankalpa Chakraborty, Rince John, Alo Nag

Published in: Tumor Biology | Issue 7/2014

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Abstract

Emerging new and intriguing roles of cytoglobin (Cygb) have attracted considerable attention of cancer researchers in recent years. Hypoxic upregulation of Cygb as well as its altered expression in various human cancers suggest another possible role of this newly discovered globin in tumor cell response under low oxygen tension. Since tumor hypoxia is strongly associated with malignant progression of disease and poor treatment response, it constitutes an area of paramount importance for rational design of cancer selective therapies. However, the mechanisms involved during this process are still elusive. This review outlines the current understanding of Cygb’s involvement in tumor hypoxia and discusses its role in tumorigenesis. A better perception of Cygb in tumor hypoxia response is likely to open novel perspectives for future tumor therapy.
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Metadata
Title
Cytoglobin in tumor hypoxia: novel insights into cancer suppression
Authors
Sankalpa Chakraborty
Rince John
Alo Nag
Publication date
01-07-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 7/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-014-1992-z

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