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Published in: World Journal of Urology 2/2021

01-02-2021 | Cystectomy | Original Article

Safety of decreasing ureteral stent duration following radical cystectomy

Authors: Hamza Beano, Jiaxian He, Caitlin Hensel, William Worrilow, William Townsend, Kris Gaston, Peter E. Clark, Stephen Riggs

Published in: World Journal of Urology | Issue 2/2021

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Abstract

Purpose

We aim to assess the safety of decreasing ureteral stenting duration following Radical Cystectomy with Urinary Diversion (RCUD).

Materials and methods

We analyzed a prospectively and retrospectively collected dataset for cystectomy patients at our tertiary center. Adult patient who underwent RCUD for malignancy from January 2013 to February 2018 were included. Patients with a history of abdominal/pelvic radiation and continent diversions were excluded. The patient population was divided to late stent removal group (LSR-POD 14) and early stent removal group (ESR-POD5). Our endpoints were total stent duration, 90-day readmission, 90-day total-UTI, 90-day urinary-readmissions, complications and Ureteroenteric Stricture (UES) rates. Statistical methods included t test, Chi-squared test and multivariate logistic regression.

Results

One hundred and seventy-eight patients were included in the final analysis after inclusion/exclusion criteria were applied. The LSR (n = 74) and ESR (n = 104) groups were similar in preoperative characteristics except higher intracorporeal ileal conduit formation in ESR. The duration of stenting decreased significantly from approximately 15.5–5 days (P < 0.001). The LSR had higher 90-day overall readmission rates (OR = 2.57, 95% CI 1.19–5.53, P = 0.016) and total-UTIs (OR = 2.36, 95%CI 1.11–5.04, P = 0.026). With a median follow-up of 9.8 months, UES was similar between the two groups.

Conclusion

Shorter ureteral stent duration is a safe and non-inferior option following RCUD. It allows for stent removal prior to discharge and less outpatient visits. In addition, decreasing stent duration was linked decreased readmissions and total-UTIs without increased risk of UES. However, future studies are needed to establish causality and promote stent duration change.
Literature
1.
go back to reference Parekh DJ, Reis IM, Castle EP et al (2018) Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial. Lancet 391(10139):2525–2536CrossRef Parekh DJ, Reis IM, Castle EP et al (2018) Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial. Lancet 391(10139):2525–2536CrossRef
2.
go back to reference Novara G, Catto JW, Wilson T et al (2015) Systematic review and cumulative analysis of perioperative outcomes and complications after robot-assisted radical cystectomy. Eur Urol 67(3):376–401CrossRef Novara G, Catto JW, Wilson T et al (2015) Systematic review and cumulative analysis of perioperative outcomes and complications after robot-assisted radical cystectomy. Eur Urol 67(3):376–401CrossRef
3.
go back to reference Mossanen M, Krasnow RE, Lipsitz SR et al (2018) Associations of specific postoperative complications with costs after radical cystectomy. BJU international 121(3):428–436CrossRef Mossanen M, Krasnow RE, Lipsitz SR et al (2018) Associations of specific postoperative complications with costs after radical cystectomy. BJU international 121(3):428–436CrossRef
4.
go back to reference Nielsen ME, Mallin K, Weaver MA et al (2014) Association of hospital volume with conditional 90-day mortality after cystectomy: an analysis of the National Cancer Data Base. BJU international 114(1):46–55CrossRef Nielsen ME, Mallin K, Weaver MA et al (2014) Association of hospital volume with conditional 90-day mortality after cystectomy: an analysis of the National Cancer Data Base. BJU international 114(1):46–55CrossRef
5.
go back to reference Semerjian A, Milbar N, Kates M et al (2018) Hospital charges and length of stay following radical cystectomy in the enhanced recovery after surgery era. Urology 111:86–91CrossRef Semerjian A, Milbar N, Kates M et al (2018) Hospital charges and length of stay following radical cystectomy in the enhanced recovery after surgery era. Urology 111:86–91CrossRef
6.
go back to reference Kim SP, Shah ND, Karnes RJ et al (2012) The implications of hospital acquired adverse events on mortality, length of stay and costs for patients undergoing radical cystectomy for bladder cancer. J Urol 187(6):2011–2017CrossRef Kim SP, Shah ND, Karnes RJ et al (2012) The implications of hospital acquired adverse events on mortality, length of stay and costs for patients undergoing radical cystectomy for bladder cancer. J Urol 187(6):2011–2017CrossRef
7.
go back to reference Davies BJ, Allareddy V, Konety BR (2009) Effect of postcystectomy infectious complications on cost, length of stay, and mortality. Urology 73(3):598–602CrossRef Davies BJ, Allareddy V, Konety BR (2009) Effect of postcystectomy infectious complications on cost, length of stay, and mortality. Urology 73(3):598–602CrossRef
8.
go back to reference Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213CrossRef Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213CrossRef
9.
go back to reference Spiess PE, Agarwal N, Bangs R et al (2017) Bladder cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Cancer Netw JNCCN. 15(10):1240–1267CrossRef Spiess PE, Agarwal N, Bangs R et al (2017) Bladder cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Cancer Netw JNCCN. 15(10):1240–1267CrossRef
10.
go back to reference Mattei A, Birkhaeuser FD, Baermann C, Warncke SH, Studer UE (2008) To stent or not to stent perioperatively the ureteroileal anastomosis of ileal orthotopic bladder substitutes and ileal conduits? Results of a prospective randomized trial. J Urol 179(2):582–586CrossRef Mattei A, Birkhaeuser FD, Baermann C, Warncke SH, Studer UE (2008) To stent or not to stent perioperatively the ureteroileal anastomosis of ileal orthotopic bladder substitutes and ileal conduits? Results of a prospective randomized trial. J Urol 179(2):582–586CrossRef
11.
go back to reference Clifford TG, Katebian B, Van Horn CM et al (2018) Urinary tract infections following radical cystectomy and urinary diversion: a review of 1133 patients. World J Urol 36(5):775–781CrossRef Clifford TG, Katebian B, Van Horn CM et al (2018) Urinary tract infections following radical cystectomy and urinary diversion: a review of 1133 patients. World J Urol 36(5):775–781CrossRef
12.
go back to reference Sood A, Kachroo N, Abdollah F et al (2017) An evaluation of the timing of surgical complications following radical cystectomy: data from the American College of Surgeons National Surgical Quality Improvement Program. Urology 103:91–98CrossRef Sood A, Kachroo N, Abdollah F et al (2017) An evaluation of the timing of surgical complications following radical cystectomy: data from the American College of Surgeons National Surgical Quality Improvement Program. Urology 103:91–98CrossRef
13.
go back to reference Al-Daghmin A, Aboumohamed A, Din R et al (2014) Readmission after robot-assisted radical cystectomy: outcomes and predictors at 90-day follow-up. Urology 83(2):350–356CrossRef Al-Daghmin A, Aboumohamed A, Din R et al (2014) Readmission after robot-assisted radical cystectomy: outcomes and predictors at 90-day follow-up. Urology 83(2):350–356CrossRef
14.
go back to reference Werntz RP, Martinez-Acevedo A, Amadi H et al (2018) Prophylactic antibiotics following radical cystectomy reduces urinary tract infections and readmission for sepsis from a urinary source. Urol Oncology. 36(5):23e231-e235 Werntz RP, Martinez-Acevedo A, Amadi H et al (2018) Prophylactic antibiotics following radical cystectomy reduces urinary tract infections and readmission for sepsis from a urinary source. Urol Oncology. 36(5):23e231-e235
15.
go back to reference Pariser JJ, Anderson BB, Pearce SM et al (2016) The effect of broader, directed antimicrobial prophylaxis including fungal coverage on perioperative infectious complications after radical cystectomy. Urol Oncol. 34(3):121e129-114CrossRef Pariser JJ, Anderson BB, Pearce SM et al (2016) The effect of broader, directed antimicrobial prophylaxis including fungal coverage on perioperative infectious complications after radical cystectomy. Urol Oncol. 34(3):121e129-114CrossRef
16.
go back to reference Regan JB, Barrett DM (1985) Stented versus nonstented ureteroileal anastomoses: is there a difference with regard to leak and stricture? J Urol 134(6):1101–1103CrossRef Regan JB, Barrett DM (1985) Stented versus nonstented ureteroileal anastomoses: is there a difference with regard to leak and stricture? J Urol 134(6):1101–1103CrossRef
17.
go back to reference Mullins JK, Guzzo TJ, Ball MW et al (2012) Ureteral stents placed at the time of urinary diversion decreases postoperative morbidity. Urologiainternationalis 88(1):66–70 Mullins JK, Guzzo TJ, Ball MW et al (2012) Ureteral stents placed at the time of urinary diversion decreases postoperative morbidity. Urologiainternationalis 88(1):66–70
18.
go back to reference Large MC, Cohn JA, Kiriluk KJ et al (2013) The impact of running versus interrupted anastomosis on ureterointestinal stricture rate after radical cystectomy. J Urol 190(3):923–927CrossRef Large MC, Cohn JA, Kiriluk KJ et al (2013) The impact of running versus interrupted anastomosis on ureterointestinal stricture rate after radical cystectomy. J Urol 190(3):923–927CrossRef
19.
go back to reference Lobo N, Dupre S, Sahai A, Thurairaja R, Khan MS (2016) Getting out of a tight spot: an overview of ureteroenteric anastomotic strictures Nature reviews. Urology. 13(8):447–455PubMed Lobo N, Dupre S, Sahai A, Thurairaja R, Khan MS (2016) Getting out of a tight spot: an overview of ureteroenteric anastomotic strictures Nature reviews. Urology. 13(8):447–455PubMed
20.
go back to reference Shah SH, Movassaghi K, Skinner D et al (2015) Ureteroenteric strictures after open radical cystectomy and urinary diversion: the university of southern california experience. Urology 86(1):87–91CrossRef Shah SH, Movassaghi K, Skinner D et al (2015) Ureteroenteric strictures after open radical cystectomy and urinary diversion: the university of southern california experience. Urology 86(1):87–91CrossRef
21.
go back to reference Ahmed YE, Hussein AA, May PR et al (2017) Natural history, predictors and management of ureteroenteric strictures after robot assisted radical cystectomy. J Urol 198(3):567–574CrossRef Ahmed YE, Hussein AA, May PR et al (2017) Natural history, predictors and management of ureteroenteric strictures after robot assisted radical cystectomy. J Urol 198(3):567–574CrossRef
22.
go back to reference Tuderti G, Brassetti A, Minisola F, Anceschi U, Ferriero M, Leonardo C et al (2019) Transnephrostomic indocyanine green-guided robotic ureteral reimplantation for benign ureteroileal strictures after robotic cystectomy and intracorporeal neobladder: step-by-step surgical technique. Perioper Funct Outcomes J Endourol 33(10):823–828 Tuderti G, Brassetti A, Minisola F, Anceschi U, Ferriero M, Leonardo C et al (2019) Transnephrostomic indocyanine green-guided robotic ureteral reimplantation for benign ureteroileal strictures after robotic cystectomy and intracorporeal neobladder: step-by-step surgical technique. Perioper Funct Outcomes J Endourol 33(10):823–828
23.
go back to reference Arora N, Jones S, Riggs SB (2017) Enhanced recovery after surgery: principles and application to urological surgery. AUA Update Ser 36(36):350–360 Arora N, Jones S, Riggs SB (2017) Enhanced recovery after surgery: principles and application to urological surgery. AUA Update Ser 36(36):350–360
24.
go back to reference Hensel C, Beano H, He J, et al (2018) Comparing intracorporeal and extracorporeal diversions following robotic radical cystectomy. In: POSTER PRESENTATION: 82nd Annual meeting of the SouthEastern Section of the AUA. March 22–25 2018. Orlando, FL, 2018 Hensel C, Beano H, He J, et al (2018) Comparing intracorporeal and extracorporeal diversions following robotic radical cystectomy. In: POSTER PRESENTATION: 82nd Annual meeting of the SouthEastern Section of the AUA. March 22–25 2018. Orlando, FL, 2018
Metadata
Title
Safety of decreasing ureteral stent duration following radical cystectomy
Authors
Hamza Beano
Jiaxian He
Caitlin Hensel
William Worrilow
William Townsend
Kris Gaston
Peter E. Clark
Stephen Riggs
Publication date
01-02-2021
Publisher
Springer Berlin Heidelberg
Keyword
Cystectomy
Published in
World Journal of Urology / Issue 2/2021
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-020-03191-2

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