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Journal of Assisted Reproduction and Genetics

Published in:

01-08-2008 | GENETICS

CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women

Authors: Yi Ye, Xiao Cheng, Hai-Bo Luo, Li Liu, Ying-Bi Li, Yi-Ping Hou

Published in: Journal of Assisted Reproduction and Genetics | Issue 8/2008

Abstract

Purpose

The aim of the study was to evaluate the association of CYP1A1 and CYP1B1 polymorphisms with uterine leiomyoma in Chinese women.

Methods

We investigated 100 women with clinically diagnosed uterine leiomyoma and 110 healthy normal subjects from Chinese women. The genetic distribution of two CYP1A1 polymorphisms at MspI, Ile462Val and four CYP1B1 polymorphisms at Arg48Gly, Ala119Ser, Leu432Val, Asp449Asp were analyzed by polymerase chain reaction–restriction fragment length polymorphism and DNA sequencing method.

Results

All the SNPs showed polymorphisms in Chinese women. The genotype A/G and the allele G on Ile462Val was significantly different between uterine leiomyoma patients and controls (P < 0.05).

Conclusion

These results suggest that the genotype of CYP1A1 Ile462Val was associated with the increased risk of uterine leiomyomas in Chinese women.

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Title: CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women
Authors: Yi Ye
Xiao Cheng
Hai-Bo Luo
Li Liu
Ying-Bi Li
Yi-Ping Hou
Publication date: 01-08-2008
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 8/2008
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-008-9246-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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