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Virology Journal
Published in: Virology Journal 1/2007

Open Access 01-12-2007 | Short report

Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection

Authors: Matthijs Raaben, Alexandra WC Einerhand, Lucas JA Taminiau, Michel van Houdt, Janneke Bouma, Rolien H Raatgeep, Hans A Büller, Cornelis AM de Haan, John WA Rossen

Published in: Virology Journal | Issue 1/2007

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Abstract

Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy.
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Literature
1.
Spencer AG, Woods JW, Arakawa T, Singer, Smith WL: Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy. J Biol Chem 1998,273(16):9886-9893. 10.1074/jbc.273.16.9886PubMedCrossRef
2.
Newton R, Kuitert LM, Bergmann M, Adcock IM, Barnes PJ: Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta. Biochem Biophys Res Commun 1997,237(1):28-32. 10.1006/bbrc.1997.7064PubMedCrossRef
3.
Newton R, Stevens DA, Hart LA, Lindsay M, Adcock IM, Barnes PJ: Superinduction of COX-2 mRNA by cycloheximide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation. FEBS Lett 1997,418(1-2):135-138. 10.1016/S0014-5793(97)01362-8PubMedCrossRef
4.
Betz M, Fox BS: Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J Immunol 1991,146(1):108-113.PubMed
5.
Hasler F, Bluestein HG, Zvaifler NJ, Epstein LB: Analysis of the defects responsible for the impaired regulation of EBV-induced B cell proliferation by rheumatoid arthritis lymphocytes. II. Role of monocytes and the increased sensitivity of rheumatoid arthritis lymphocytes to prostaglandin E. J Immunol 1983,131(2):768-772.PubMed
6.
Steer SA, Corbett JA: The role and regulation of COX-2 during viral infection. Viral Immunol 2003,16(4):447-460. 10.1089/088282403771926283PubMedCrossRef
7.
Baker DA, Thomas J, Epstein J, Possilico D, Stone ML: The effect of prostaglandins on the multiplication and cell-to-cell spread of herpes simplex virus type 2 in vitro. Am J Obstet Gynecol 1982,144(3):346-349.PubMed
8.
Janelle ME, Gravel A, Gosselin J, Tremblay MJ, Flamand L: Activation of monocyte cyclooxygenase-2 gene expression by human herpesvirus 6. Role for cyclic AMP-responsive element-binding protein and activator protein-1. J Biol Chem 2002,277(34):30665-30674. 10.1074/jbc.M203041200PubMedCrossRef
9.
Symensma TL, Martinez-Guzman D, Jia Q, Bortz E, Wu TT, Rudra-Ganguly N, Cole S, Herschman H, Sun R: COX-2 induction during murine gammaherpesvirus 68 infection leads to enhancement of viral gene expression. J Virol 2003,77(23):12753-12763. 10.1128/JVI.77.23.12753-12763.2003PubMedPubMedCentralCrossRef
10.
Thiry E, Mignon B, Thalasso F, Pastoret PP: Effect of prostaglandins PGE2 and PGF alpha 2 on the mean plaque size of bovine herpesvirus 1. Ann Rech Vet 1988,19(4):291-293.PubMed
11.
Zhu H, Cong JP, Yu D, Bresnahan WA, Shenk TE: Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication. Proc Natl Acad Sci U S A 2002,99(6):3932-3937. 10.1073/pnas.052713799PubMedPubMedCentralCrossRef
12.
Ray N, Bisher ME, Enquist LW: Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. J Virol 2004,78(23):12964-12974. 10.1128/JVI.78.23.12964-12974.2004PubMedPubMedCentralCrossRef
13.
Rott D, Zhu J, Burnett MS, Zhou YF, Zalles-Ganley A, Ogunmakinwa J, Epstein SE: Effects of MF-tricyclic, a selective cyclooxygenase-2 inhibitor, on atherosclerosis progression and susceptibility to cytomegalovirus replication in apolipoprotein-E knockout mice. J Am Coll Cardiol 2003,41(10):1812-1819. 10.1016/S0735-1097(03)00304-8PubMedCrossRef
14.
Pyeon D, Diaz FJ, Splitter GA: Prostaglandin E(2) increases bovine leukemia virus tax and pol mRNA levels via cyclooxygenase 2: regulation by interleukin-2, interleukin-10, and bovine leukemia virus. J Virol 2000,74(12):5740-5745. 10.1128/JVI.74.12.5740-5745.2000PubMedPubMedCentralCrossRef
15.
Rossen JW, Bouma J, Raatgeep RH, Buller HA, Einerhand AW: Inhibition of cyclooxygenase activity reduces rotavirus infection at a postbinding step. J Virol 2004,78(18):9721-9730. 10.1128/JVI.78.18.9721-9730.2004PubMedPubMedCentralCrossRef
16.
Kline JN, Hunninghake GM, He B, Monick MM, Hunninghake GW: Synergistic activation of the human cytomegalovirus major immediate early promoter by prostaglandin E2 and cytokines. Exp Lung Res 1998,24(1):3-14.PubMedCrossRef
17.
Moriuchi M, Inoue H, Moriuchi H: Reciprocal interactions between human T-lymphotropic virus type 1 and prostaglandins: implications for viral transmission. J Virol 2001,75(1):192-198. 10.1128/JVI.75.1.192-198.2001PubMedPubMedCentralCrossRef
18.
Dumais N, Barbeau B, Olivier M, Tremblay MJ: Prostaglandin E2 Up-regulates HIV-1 long terminal repeat-driven gene activity in T cells via NF-kappaB-dependent and -independent signaling pathways. J Biol Chem 1998,273(42):27306-27314. 10.1074/jbc.273.42.27306PubMedCrossRef
19.
Hayes MM, Lane BR, King SR, Markovitz DM, Coffey MJ: Prostaglandin E(2) inhibits replication of HIV-1 in macrophages through activation of protein kinase A. Cell Immunol 2002,215(1):61-71. 10.1016/S0008-8749(02)00017-5PubMedCrossRef
20.
Ongradi J, Telekes A, Farkas J, Nasz I, Bendinelli M: The effect of prostaglandins on the replication of adenovirus wild types and temperature-sensitive mutants. Acta Microbiol Immunol Hung 1994,41(2):173-188.PubMed
21.
Weiss SR, Navas-Martin S: Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev 2005,69(4):635-664. 10.1128/MMBR.69.4.635-664.2005PubMedPubMedCentralCrossRef
22.
Drosten C, Gunther S, Preiser W, van der Werf S, Brodt HR, Becker S, Rabenau H, Panning M, Kolesnikova L, Fouchier RA, Berger A, Burguiere AM, Cinatl J, Eickmann M, Escriou N, Grywna K, Kramme S, Manuguerra JC, Muller S, Rickerts V, Sturmer M, Vieth S, Klenk HD, Osterhaus AD, Schmitz H, Doerr HW: Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003,348(20):1967-1976. 10.1056/NEJMoa030747PubMedCrossRef
23.
van der Hoek L, Pyrc K, Jebbink MF, Vermeulen-Oost W, Berkhout RJ, Wolthers KC, Wertheim-van Dillen PM, Kaandorp J, Spaargaren J, Berkhout B: Identification of a new human coronavirus. Nat Med 2004,10(4):368-373. 10.1038/nm1024PubMedCrossRef
24.
Woo PC, Lau SK, Chu CM, Chan KH, Tsoi HW, Huang Y, Wong BH, Poon RW, Cai JJ, Luk WK, Poon LL, Wong SS, Guan Y, Peiris JS, Yuen KY: Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J Virol 2005,79(2):884-895. 10.1128/JVI.79.2.884-895.2005PubMedPubMedCentralCrossRef
25.
Pope M, Rotstein O, Cole E, Sinclair S, Parr R, Cruz B, Fingerote R, Chung S, Gorczynski R, Fung L, et al.: Pattern of disease after murine hepatitis virus strain 3 infection correlates with macrophage activation and not viral replication. J Virol 1995,69(9):5252-5260.PubMedPubMedCentral
26.
Abecassis M, Falk J, Dindzans V, Lopatin W, Makowka L, Levy G, Falk R: Prostaglandin E2 (PGE2) alters the pathogenesis of MHV-3 infection in susceptible BALB/cJ mice. Adv Exp Med Biol 1987, 218: 465-466.PubMedCrossRef
27.
Liu M, Gu C, Wu J, Zhu Y: Amino acids 1 to 422 of the spike protein of SARS associated coronavirus are required for induction of cyclooxygenase-2. Virus Genes 2006,33(3):309-317. 10.1007/s11262-005-0070-4PubMedCrossRef
28.
Yan X, Hao Q, Mu Y, Timani KA, Ye L, Zhu Y, Wu J: Nucleocapsid protein of SARS-CoV activates the expression of cyclooxygenase-2 by binding directly to regulatory elements for nuclear factor-kappa B and CCAAT/enhancer binding protein. Int J Biochem Cell Biol 2006,38(8):1417-1428. 10.1016/j.biocel.2006.02.003PubMedCrossRef
29.
Liu M, Yang Y, Gu C, Yue Y, Wu KK, Wu J, Zhu Y: Spike protein of SARS-CoV stimulates cyclooxygenase-2 expression via both calcium-dependent and calcium-independent protein kinase C pathways. Faseb J 2007.
30.
Lee CH, Chen RF, Liu JW, Yeh WT, Chang JC, Liu PM, Eng HL, Lin MC, Yang KD: Altered p38 mitogen-activated protein kinase expression in different leukocytes with increment of immunosuppressive mediators in patients with severe acute respiratory syndrome. J Immunol 2004,172(12):7841-7847.PubMedCrossRef
31.
Rossen JW, Strous GJ, Horzinek MC, Rottier PJ: Mouse hepatitis virus strain A59 is released from opposite sides of different epithelial cell types. J Gen Virol 1997, 78 ( Pt 1): 61-69.CrossRef
32.
Rottier PJ, Horzinek MC, van der Zeijst BA: Viral protein synthesis in mouse hepatitis virus strain A59-infected cells: effect of tunicamycin. J Virol 1981,40(2):350-357.PubMedPubMedCentral
33.
de Haan CA, Li Z, te Lintelo E, Bosch BJ, Haijema BJ, Rottier PJ: Murine coronavirus with an extended host range uses heparan sulfate as an entry receptor. J Virol 2005,79(22):14451-14456. 10.1128/JVI.79.22.14451-14456.2005PubMedPubMedCentralCrossRef
34.
de Haan CA, van Genne L, Stoop JN, Volders H, Rottier PJ: Coronaviruses as vectors: position dependence of foreign gene expression. J Virol 2003,77(21):11312-11323. 10.1128/JVI.77.21.11312-11323.2003PubMedPubMedCentralCrossRef
35.
Vennema H, Heijnen L, Zijderveld A, Horzinek MC, Spaan WJ: Intracellular transport of recombinant coronavirus spike proteins: implications for virus assembly. J Virol 1990,64(1):339-346.PubMedPubMedCentral
36.
Amici C, Di Coro A, Ciucci A, Chiappa L, Castilletti C, Martella V, Decaro N, Buonavoglia C, Capobianchi MR, Santoro MG: Indomethacin has a potent antiviral activity against SARS coronavirus. Antivir Ther 2006,11(8):1021-1030.PubMed
37.
Verheije MH, Wurdinger T, van Beusechem VW, de Haan CA, Gerritsen WR, Rottier PJ: Redirecting coronavirus to a nonnative receptor through a virus-encoded targeting adapter. J Virol 2006,80(3):1250-1260. 10.1128/JVI.80.3.1250-1260.2006PubMedPubMedCentralCrossRef
Metadata
Title
Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection
Authors
Matthijs Raaben
Alexandra WC Einerhand
Lucas JA Taminiau
Michel van Houdt
Janneke Bouma
Rolien H Raatgeep
Hans A Büller
Cornelis AM de Haan
John WA Rossen
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2007
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-4-55

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