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International Urogynecology Journal

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01-04-2010 | Original Article

Cyclical estrogen and free radical damage to the rabbit urinary bladder

Authors: Alexandra Rehfuss, Catherine Schuler, Christina Maxemous, Robert E. Leggett, Robert M. Levin

Published in: International Urogynecology Journal | Issue 4/2010

Abstract

Introduction and hypothesis

There are a number of lower urinary tract dysfunctions (LUTD) that occur primarily in women. Our hypothesis is that cyclical estrogen will produce LUTD in part by the generation of free radicals and oxidative damage to cellular and subcellular membranes.

Methods

Twenty female rabbits were divided into five groups: control, ovariectomized (Ovx), Ovx receiving continuous estrogen, Ovx receiving cyclical estrogen ending off estrogen, and Ovx receiving cyclical estrogen ending on estrogen. Statistical analyses used ANOVA followed by the Tukey analysis for individual differences.

Results

High estrogen increased bladder mass, contraction, compliance, and blood flow and decreased oxidative damage. Low estrogen decreased bladder mass, contraction, compliance, and blood flow and increased oxidative damage.

Conclusions

The decreased blood flow associated with increased oxidative damage demonstrates that cyclical damage to cellular membranes occurs. This supports the hypothesis that cycling estrogen may play a role in the etiology of LUTD of women.

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Title: Cyclical estrogen and free radical damage to the rabbit urinary bladder
Authors: Alexandra Rehfuss
Catherine Schuler
Christina Maxemous
Robert E. Leggett
Robert M. Levin
Publication date: 01-04-2010
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 4/2010
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-009-1048-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cyclical estrogen and free radical damage to the rabbit urinary bladder

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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