Cyanosis in a male Nigerian infant with acute kidney injury: Questions

Excerpt

A 10-week-old Nigerian boy was referred to our hospital with a history of feeding difficulties, poor weight gain and recurrent vomiting. The mother had not noticed any changes in the frequency of wet diapers. Family and patient histories were unremarkable except for neonatal jaundice in the propositus. Apart from vitamin D supplementation (400 IU/day) no drug intake was reported. On admission he appeared well and alert, but showed signs of dehydration. Otherwise, physical examination was unremarkable. His weight was 4,660 g; temperature, 36.7 °C; pulse rate, 135/min; blood pressure, 90/55 mmHg. Laboratory investigations revealed a serum creatinine of 1.98 (normal 0.2–0.5) mg/dL and urea of 226 (normal 14–40) mg/dL. Serum uric acid was 22 (normal 3.6–6) mg/dL. Acid–base status was normal. Serum Na⁺ was 130 mmol/L; K⁺, 4.2 mmol/L; iCa²⁺, 1.04 mmol/L; phosphate, 2.92 (normal 1.13–2.13) mmol/L. Blood hemoglobin level was normal (11.6 g/dL). No blasts were visible on peripheral blood smears. Analysis of a urine catheter sample (Na⁺ 12 mmol/L, osmolality 445 mosmol/kg, protein/creatinine ratio 0.62 g/g) and fractional excretion of sodium (0.29 %) indicated predominantly prerenal acute kidney injury. Ultrasound showed normal-sized kidneys with medullary hyperechogenicity. Abdominal lymphadenopathy and organomegaly were absent. A chest X-ray was normal. …