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Published in: Cancer Immunology, Immunotherapy 9/2013

01-09-2013 | Original Article

CXCR5 polymorphisms in non-Hodgkin lymphoma risk and prognosis

Authors: Bridget Charbonneau, Alice H. Wang, Matthew J. Maurer, Yan W. Asmann, Clive S. Zent, Brian K. Link, Stephen M. Ansell, George J. Weiner, Nazan Ozsan, Andrew L. Feldman, Thomas E. Witzig, Julie M. Cunningham, Ahmet Dogan, Thomas M. Habermann, Susan L. Slager, Anne J. Novak, James R. Cerhan

Published in: Cancer Immunology, Immunotherapy | Issue 9/2013

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Abstract

CXCR5 [chemokine (C-X-C motif) receptor 5; also known as Burkitt lymphoma receptor 1 (BCR1)] is expressed on mature B-cells, subsets of CD4+ and CD8+ T-cells, and skin-derived migratory dendritic cells. Together with its ligand, CXCL13, CXCR5 is involved in guiding B-cells into the B-cell zones of secondary lymphoid organs as well as T-cell migration. This study evaluated the role of common germline genetic variation in CXCR5 in the risk and prognosis of non-Hodgkin lymphoma (NHL) using a clinic-based study of 1,521 controls and 2,694 NHL cases including 710 chronic lymphocytic leukemia/small lymphocytic lymphoma, 586 diffuse large B-cell lymphoma (DLBCL), 588 follicular lymphoma (FL), 137 mantle cell lymphoma (MCL), 230 marginal zone lymphoma (MZL), and 158 peripheral T-cell lymphoma (PTCL). Of the ten CXCR5 tag SNPs in our study, five were associated with risk of NHL, with rs1790192 having the strongest association (OR 1.19, 95 % CI 1.08–1.30; p = 0.0003). This SNP was most strongly associated with the risk of FL (OR 1.44, 95 % CI 1.25–1.66; p = 3.1 × 10−7), with a lower degree of association with DLBCL (OR 1.16, 95 % CI 1.01–1.33; p = 0.04) and PTCL (OR 1.29, 95 % CI 1.02–1.64; p = 0.04) but no association with the risk of MCL or MZL. For FL patients that were observed as initial disease management, the number of minor alleles of rs1790192 was associated with better event-free survival (HR 0.64; 95 % CI 0.47–0.87; p = 0.004). These results provide additional evidence for a role of host genetic variation in CXCR5 in lymphomagenesis, particularly for FL.
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Metadata
Title
CXCR5 polymorphisms in non-Hodgkin lymphoma risk and prognosis
Authors
Bridget Charbonneau
Alice H. Wang
Matthew J. Maurer
Yan W. Asmann
Clive S. Zent
Brian K. Link
Stephen M. Ansell
George J. Weiner
Nazan Ozsan
Andrew L. Feldman
Thomas E. Witzig
Julie M. Cunningham
Ahmet Dogan
Thomas M. Habermann
Susan L. Slager
Anne J. Novak
James R. Cerhan
Publication date
01-09-2013
Publisher
Springer Berlin Heidelberg
Published in
Cancer Immunology, Immunotherapy / Issue 9/2013
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-013-1452-4

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