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Neurosurgical Review
Published in: Neurosurgical Review 1/2014

01-01-2014 | Review

Current status of bone graft options for anterior interbody fusion of the cervical and lumbar spine

Authors: Anthony Minh Tien Chau, Lileane Liang Xu, Johnny Ho-Yin Wong, Ralph Jasper Mobbs

Published in: Neurosurgical Review | Issue 1/2014

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Abstract

Anterior cervical discectomy and fusion (ACDF) and anterior lumbar interbody fusion (ALIF) are common surgical procedures for degenerative disc disease of the cervical and lumbar spine. Over the years, many bone graft options have been developed and investigated aimed at complimenting or substituting autograft bone, the traditional fusion substrate. Here, we summarise the historical context, biological basis and current best evidence for these bone graft options in ACDF and ALIF.
Literature
1.
Abdullah KG, Steinmetz MP, Benzel EC, Mroz TE (2011) The state of lumbar fusion extenders. Spine 36:E1328–1334PubMed
2.
Ackerman SJ, Mafilios MS, Polly DW Jr (2002) Economic evaluation of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion: an evidence-based modeling approach. Spine 27:S94–99PubMed
3.
Agarwal R, Williams K, Umscheid CA, Welch WC (2009) Osteoinductive bone graft substitutes for lumbar fusion: a systematic review. J Neurosurg Spine 11:729–740PubMed
4.
Alden TD, Pittman DD, Beres EJ, Hankins GR, Kallmes DF, Wisotsky BM, Kerns KM, Helm GA (1999) Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy. J Neurosurg 90:109–114PubMed
5.
An HS, Simpson JM, Glover JM, Stephany J (1995) Comparison between allograft plus demineralized bone matrix versus autograft in anterior cervical fusion. A prospective multicenter study. Spine 20:2211–2216PubMed
6.
Arlet V, Jiang L, Steffen T, Ouellet J, Reindl R, Aebi M (2006) Harvesting local cylinder autograft from adjacent vertebral body for anterior lumbar interbody fusion: surgical technique, operative feasibility and preliminary clinical results. Eur Spine J 15:1352–1359PubMedCentralPubMed
7.
Arora NS, Ramanayake T, Ren Y-F, Romanos GE (2009) Platelet-rich plasma: a literature review. Implant Dent 18:303–310PubMed
8.
Bae H, Zhao L, Zhu D, Kanim LE, Wang JC, Delamarter RB (2010) Variability across ten production lots of a single demineralized bone matrix product. J Bone Joint Surg Am 92:427–435PubMed
9.
Bae HW, Zhao L, Kanim LEA, Wong P, Delamarter RB, Dawson EG (2006) Intervariability and intravariability of bone morphogenetic proteins in commercially available demineralized bone matrix products. Spine 31:1299–1306, discussion 1307–1298PubMed
10.
Bailey RW, Badgley CE (1960) Stabilization of the cervical spine by anterior fusion. J Bone Joint Surg Am 42-A:565–594PubMed
11.
Baskin DS, Ryan P, Sonntag V, Westmark R, Widmayer MA (2003) A prospective, randomized, controlled cervical fusion study using recombinant human bone morphogenetic protein-2 with the CORNERSTONE-SR allograft ring and the ATLANTIS anterior cervical plate. Spine 28:1219–1224, discussion 1225PubMed
12.
Bishop RC, Moore KA, Hadley MN (1996) Anterior cervical interbody fusion using autogeneic and allogeneic bone graft substrate: a prospective comparative analysis. J Neurosurg 85:206–210PubMed
13.
Blokhuis TJ, Termaat MF, den Boer FC, Patka P, Bakker FC, Haarman HJ (2000) Properties of calcium phosphate ceramics in relation to their in vivo behavior. J Trauma-Injury Infection Critical Care 48:179–186
14.
Boden SD, Zdeblick TA, Sandhu HS, Heim SE (2000) The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report. Spine 25:376–381PubMed
15.
Brand RA (2009) Marshall R. Urist, 1914–2001. Clin Orthop Rela Res 467:3049–3050
16.
Brown MD, Malinin TI, Davis PB (1976) A roentgenographic evaluation of frozen allografts versus autografts in anterior cervical fusions. Clin Orthop Relat Res 119:231–236
17.
Burkus JK, Gornet MF, Dickman CA, Zdeblick TA (2002) Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech 15:337–349PubMed
18.
Burkus JK, Gornet MF, Glassman SD, Slosar PJ, Rosner MK, Deckey JE, Nowak J, Hatcher BM (2011) Blood serum antibody analysis and long-term follow-up of patients treated with recombinant human bone morphogenetic protein-2 in the lumbar spine. Spine 36:2158–2167PubMed
19.
Burkus JK, Gornet MF, Schuler TC, Kleeman TJ, Zdeblick TA (2009) Six-year outcomes of anterior lumbar interbody arthrodesis with use of interbody fusion cages and recombinant human bone morphogenetic protein-2. J Bone Joint Surg Am 91:1181–1189PubMed
20.
Burkus JK, Sandhu HS, Gornet MF, Longley MC (2005) Use of rhBMP-2 in combination with structural cortical allografts: clinical and radiographic outcomes in anterior lumbar spinal surgery. J Bone Joint Surg Am 87:1205–1212PubMed
21.
Burkus JK, Transfeldt EE, Kitchel SH, Watkins RG, Balderston RA (2002) Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2. Spine 27:2396–2408PubMed
22.
Burns BH (1933) An operation for spondylolisthesis. Lancet 1:1233
23.
Buttermann GR (2008) Prospective nonrandomized comparison of an allograft with bone morphogenic protein versus an iliac-crest autograft in anterior cervical discectomy and fusion. Spine J: Official Journal of the North American Spine Society 8:426–435
24.
Cahill KS, Chi JH, Groff MW, McGuire K, Afendulis CC, Claus EB (2011) Outcomes for single-level lumbar fusion: the role of bone morphogenetic protein. Spine 36:2354–2362PubMedCentralPubMed
25.
Cammisa FP Jr, Lowery G, Garfin SR, Geisler FH, Klara PM, McGuire RA, Sassard WR, Stubbs H, Block JE (2004) Two-year fusion rate equivalency between Grafton DBM gel and autograft in posterolateral spine fusion: a prospective controlled trial employing a side-by-side comparison in the same patient. Spine 29:660–666PubMed
26.
Capener N (1932) Spondylolisthesis. Br J Surg 19:374–386
27.
Carragee EJ, Hurwitz EL, Weiner BK (2011) A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J: Official Journal of the North American Spine Society 11:471–491
28.
Carragee EJ, Mitsunaga KA, Hurwitz EL, Scuderi GJ (2011) Retrograde ejaculation after anterior lumbar interbody fusion using rhBMP-2: a cohort controlled study. Spine J: Official Journal of the North American Spine Society 11:511–516
29.
30.
31.
Cho D-Y, Lee W-Y, Sheu P-C, Chen C-C (2005) Cage containing a biphasic calcium phosphate ceramic (Triosite) for the treatment of cervical spondylosis. Surg Neurol 63:497–503, discussion 503–494PubMed
32.
Cloward RB (1958) The anterior approach for removal of ruptured cervical disks. J Neurosurg 15:602–617PubMed
33.
Comer GC, Smith MW, Hurwitz EL, Mitsunaga KA, Kessler R, Carragee EJ (2012) Retrograde ejaculation after anterior lumbar interbody fusion with and without bone morphogenetic protein-2 augmentation: a 10-year cohort controlled study. Spine J: Official Journal of the North American Spine Society 12:881–890
34.
Daculsi G, Baroth S, LeGeros R (2010) 20 years of biphasic calcium phosphate bioceramics development and applications. In: Narayan R, Colombo P, Singh D, Salem J (eds) Advances in bioceramics and porous ceramics II. Wiley, Hoboken, pp 45–58
35.
Dai L-Y, Jiang L-S (2008) Anterior cervical fusion with interbody cage containing beta-tricalcium phosphate augmented with plate fixation: a prospective randomized study with 2-year follow-up. Eur Spine J 17:698–705PubMedCentralPubMed
36.
Delawi D, Dhert WJA, Rillardon L, Gay E, Prestamburgo D, Garcia-Fernandez C, Guerado E, Specchia N, Van Susante JLC, Verschoor N, van Ufford HMEQ, Oner FC (2010) A prospective, randomized, controlled, multicenter study of osteogenic protein-1 in instrumented posterolateral fusions: report on safety and feasibility. Spine 35:1185–1191PubMed
37.
Dennis JE, Haynesworth SE, Young RG, Caplan AI (1992) Osteogenesis in marrow-derived mesenchymal cell porous ceramic composites transplanted subcutaneously: effect of fibronectin and laminin on cell retention and rate of osteogenic expression. Cell Transplant 1:23–32PubMed
38.
Dennis S, Watkins R, Landaker S, Dillin W, Springer D (1989) Comparison of disc space heights after anterior lumbar interbody fusion. Spine 14:876–878PubMed
39.
Deyo RA, Ching A, Matsen L, Martin BI, Kreuter W, Jarvik JG, Angier H, Mirza SK (2012) Use of bone morphogenetic proteins in spinal fusion surgery for older adults with lumbar stenosis: trends, complications, repeat surgery, and charges. Spine 37:222–230PubMedCentralPubMed
40.
Dorozhkin SV (2010) Bioceramics of calcium orthophosphates. Biomaterials 31:1465–1485PubMed
41.
Ehrler DM, Vaccaro AR (2000) The use of allograft bone in lumbar spine surgery. Clin Orthop Relat Res 371:38–45
42.
Epstein NE (2012) Iliac crest autograft versus alternative constructs for anterior cervical spine surgery: pros, cons, and costs. Surg Neurol Int 3:S143–156PubMedCentralPubMed
43.
Falavigna A, Righesso O, Volquind D, Teles AR (2009) Anterior cervical interbody fusion with hydroxyapatite graft: clinical and radiological analysis of graft breakage. Spine 34:2769–2774PubMed
44.
Feiz-Erfan I, Harrigan M, Sonntag VKH, Harrington TR (2007) Effect of autologous platelet gel on early and late graft fusion in anterior cervical spine surgery. J Neurosurg Spine 7:496–502PubMed
45.
Glassman SD, Carreon LY, Campbell MJ, Johnson JR, Puno RM, Djurasovic M, Dimar JR (2008) The perioperative cost of Infuse bone graft in posterolateral lumbar spine fusion. Spine J: Official Journal of the North American Spine Society 8:443–448
46.
Glassman SD, Carreon LY, Djurasovic M, Campbell MJ, Puno RM, Johnson JR, Dimar JR (2008) RhBMP-2 versus iliac crest bone graft for lumbar spine fusion: a randomized, controlled trial in patients over sixty years of age. Spine 33:2843–2849PubMed
47.
Gottfried ON, Dailey AT (2008) Mesenchymal stem cell and gene therapies for spinal fusion. Neurosurgery 63:380–391, discussion 391–382PubMed
48.
Guyer RD, Tromanhauser SG, Regan JJ (2007) An economic model of one-level lumbar arthroplasty versus fusion. Spine J: Official Journal of the North American Spine Society 7:558–562
49.
Heller JG, Sasso RC, Papadopoulos SM, Anderson PA, Fessler RG, Hacker RJ, Coric D, Cauthen JC, Riew DK (2009) Comparison of BRYAN cervical disc arthroplasty with anterior cervical decompression and fusion: clinical and radiographic results of a randomized, controlled, clinical trial. Spine 34:101–107PubMed
50.
Hidaka C, Goshi K, Rawlins B, Boachie-Adjei O, Crystal RG (2003) Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone. Spine 28:2049–2057PubMed
51.
Hinsenkamp M, Muylle L, Eastlund T, Fehily D, Noel L, Strong DM (2012) Adverse reactions and events related to musculoskeletal allografts: reviewed by the World Health Organisation Project NOTIFY. Int Orthop 36:633–641PubMedCentralPubMed
52.
Ijiri S, Yamamuro T, Nakamura T, Kotani S, Notoya K (1994) Effect of sterilization on bone morphogenetic protein. J Orthop Res 12:628–636PubMed
53.
Ito H, Tsuchiya J, Asami G (1934) A new radical operation for Pott’s disease. J Bone Joint Surg Br 16:499–515
54.
Janssen ME, Lam C, Beckham R (2001) Outcomes of allogenic cages in anterior and posterior lumbar interbody fusion. Eur Spine J 2:S158–S168
55.
Jenis LG, Banco RJ, Kwon B (2006) A prospective study of autologous growth factors (AGF) in lumbar interbody fusion. Spine J: Official Journal of the North American Spine Society 6:14–20
56.
Johnsson R, Stromqvist B, Aspenberg P (2002) Randomized radiostereometric study comparing osteogenic protein-1 (BMP-7) and autograft bone in human noninstrumented posterolateral lumbar fusion: 2002 Volvo Award in clinical studies. Spine 27:2654–2661PubMed
57.
Kaito T, Ngo SS, Wang JC (2011) Ex vivo gene therapy for spinal fusion. In: Kang C (ed) Gene therapy applications. InTech, Croatia, pp 227–240
58.
Kanayama M, Hashimoto T, Shigenobu K, Yamane S, Bauer TW, Togawa D (2006) A prospective randomized study of posterolateral lumbar fusion using osteogenic protein-1 (OP-1) versus local autograft with ceramic bone substitute: emphasis of surgical exploration and histologic assessment. Spine 31:1067–1074PubMed
59.
Kang J, An H, Hilibrand A, Yoon ST, Kavanagh E, Boden S (2012) Grafton and local bone have comparable outcomes to iliac crest bone in instrumented single-level lumbar fusions. Spine 37:1083–1091PubMed
60.
Khoueir P, Oh BC, DiRisio DJ, Wang MY (2007) Multilevel anterior cervical fusion using a collagen-hydroxyapatite matrix with iliac crest bone marrow aspirate: an 18-month follow-up study. Neurosurgery 61:963–970, discussion 970–961PubMed
61.
Kim DH, Rhim R, Li L, Martha J, Swaim BH, Banco RJ, Jenis LG, Tromanhauser SG (2009) Prospective study of iliac crest bone graft harvest site pain and morbidity. Spine J: Official Journal of the North American Spine Society 9:886–892
62.
Lad SP, Nathan JK, Boakye M (2011) Trends in the use of bone morphogenetic protein as a substitute to autologous iliac crest bone grafting for spinal fusion procedures in the United States. Spine 36:E274–281PubMed
63.
Lane JD, Moore ES (1948) Transperitoneal approach to the intervertebral disc in the lumbar area. Ann Surg 127:537–551PubMed
64.
Linovitz RJ, Peppers TA (2002) Use of an advanced formulation of beta-tricalcium phosphate as a bone extender in interbody lumbar fusion. Orthopedics 25:s585–589PubMed
65.
Lofgren H, Johannsson V, Olsson T, Ryd L, Levander B (2000) Rigid fusion after Cloward operation for cervical disc disease using autograft, allograft, or xenograft: a randomized study with radiostereometric and clinical follow-up assessment. Spine 25:1908–1916PubMed
66.
Loguidice VA, Johnson RG, Guyer RD, Stith WJ, Ohnmeiss DD, Hochschuler SH, Rashbaum RF (1988) Anterior lumbar interbody fusion. Spine 13:366–369PubMed
67.
Malinin T, Temple HT (2007) Comparison of frozen and freeze-dried particulate bone allografts. Cryobiology 55:167–170PubMed
68.
McConnell JR, Freeman BJC, Debnath UK, Grevitt MP, Prince HG, Webb JK (2003) A prospective randomized comparison of coralline hydroxyapatite with autograft in cervical interbody fusion. Spine 28:317–323PubMed
69.
Miller JA, Schmatz C, Schultz AB (1988) Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens. Spine 13:173–178PubMed
70.
Moon HJ, Kim JH, Kim J-H, Kwon T-H, Chung H-S, Park Y-K (2011) The effects of anterior cervical discectomy and fusion with stand-alone cages at two contiguous levels on cervical alignment and outcomes. Acta Neurochir (Wien) 153:559–565
71.
Mummaneni PV, Burkus JK, Haid RW, Traynelis VC, Zdeblick TA (2007) Clinical and radiographic analysis of cervical disc arthroplasty compared with allograft fusion: a randomized controlled clinical trial. J Neurosurg Spine 6:198–209PubMed
72.
Murrey D, Janssen M, Delamarter R, Goldstein J, Zigler J, Tay B, Darden B (2009) Results of the prospective, randomized, controlled multicenter Food and Drug Administration investigational device exemption study of the ProDisc-C total disc replacement versus anterior discectomy and fusion for the treatment of 1-level symptomatic cervical disc disease. Spine J: Official Journal of the North American Spine Society 9:275–286
73.
Muschler GF, Boehm C, Easley K (1997) Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume. J Bone Joint Surg Am 79:1699–1709 (Erratum appears in J Bone Joint Surg Am 1998 Feb;80(2):302)PubMed
74.
Muschler GF, Nitto H, Matsukura Y, Boehm C, Valdevit A, Kambic H, Davros W, Powell K, Easley K (2003) Spine fusion using cell matrix composites enriched in bone marrow-derived cells. Clin Orth Relat Res 407:102–118
75.
Nade S, Armstrong L, McCartney E, Baggaley B (1983) Osteogenesis after bone and bone marrow transplantation. The ability of ceramic materials to sustain osteogenesis from transplanted bone marrow cells: preliminary studies. Clin Orthop Relat Res 181:255–263
76.
National Health and Medical Research Council (2009) NHMRC levels of evidence and grades for recommendations for developers of guidelines. www.​nhmrc.​gov.​au. Accessed 8 June 2011
77.
Noth U, Rackwitz L, Steinert AF, Tuan RS (2010) Cell delivery therapeutics for musculoskeletal regeneration. Advanced Drug Delivery Rev 62:765–783
78.
O’Brien JP, Dawson MH, Heard CW, Momberger G, Speck G, Weatherly CR (1986) Simultaneous combined anterior and posterior fusion. A surgical solution for failed spinal surgery with a brief review of the first 150 patients. Clin Orthop Relat Res 203:191–195
79.
Oakes DA, Lieberman JR (2000) Osteoinductive applications of regional gene therapy: ex vivo gene transfer. Clin Orthop Relat Res 379 (Suppl):S101–112
80.
Obremskey WT, Marotta JS, Yaszemski MJ, Churchill LR, Boden SD, Dirschl DR (2007) Symposium. The introduction of biologics in orthopaedics: issues of cost, commercialism, and ethics. J Bone Joint Surg Am 89:1641–1649PubMed
81.
Oskouian RJ, Pelled G, Zilberman Y, Tal Y, Gazit Z, Gazit D (2006) Novel, injectable, genetically engineered stem cell-based system for anterior spinal fusion (abstract). Mol Ther 13:S173–S174
82.
Papavero L, Zwonitzer R, Burkard I, Klose K, Herrmann H-D (2002) A composite bone graft substitute for anterior cervical fusion: assessment of osseointegration by quantitative computed tomography. Spine 27:1037–1043PubMed
83.
Park H-W, Lee J-K, Moon S-J, Seo S-K, Lee J-H, Kim S-H (2009) The efficacy of the synthetic interbody cage and Grafton for anterior cervical fusion. Spine 34:E591–595PubMed
84.
Pitzen T, Kiefer R, Munchen D, Barbier D, Reith W, Steudel WI (2006) Filling a cervical spine cage with local autograft: change of bone density and assessment of bony fusion. Zentralblatt fur Neurochirurgie 67:8–13PubMed
85.
Polly DW Jr, Ackerman SJ, Shaffrey CI, Ogilvie JW, Wang JC, Stralka SW, Mafilios MS, Heim SE, Sandhu HS (2003) A cost analysis of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion. Orthopedics 26:1027–1037PubMed
86.
Poynton AR, Lane JM (2002) Safety profile for the clinical use of bone morphogenetic proteins in the spine. Spine 27:S40–48PubMed
87.
Pradhan BB, Bae HW, Dawson EG, Patel VV, Delamarter RB (2006) Graft resorption with the use of bone morphogenetic protein: lessons from anterior lumbar interbody fusion using femoral ring allografts and recombinant human bone morphogenetic protein-2. Spine 31:E277–284PubMed
88.
Putney E, Blumberg K (2012) The effect of mesenchymal stem cell allograft on cervical and lumbar spinal fusion (abstract). Annual Meeting of the American Osteopathic Academy of Orthopedics, Colorado
89.
Putzier M, Strube P, Funk JF, Gross C, Monig H-J, Perka C, Pruss A (2009) Allogenic versus autologous cancellous bone in lumbar segmental spondylodesis: a randomized prospective study. Eur Spine J 18:687–695PubMedCentralPubMed
90.
Ray WZ, Wright NM (2009) Anterior cervical arthrodesis using an osteoconductive scaffold: the use of beta-tricalcium phosphate with local bone marrow aspirate in over 100 patients. SAS J 3:114–117
91.
Rengachary SS (2002) Bone morphogenetic proteins: basic concepts. Neurosurg Focus 13:e2
92.
Riew KD, Lou J, Wright NM, Cheng S-L, Bae KT, Avioli LV (2003) Thoracoscopic intradiscal spine fusion using a minimally invasive gene-therapy technique. J Bone Joint SurgAm 85-A:866–871
93.
Robinson RA, Smith GW (1955) Anterolateral cervical disc removal and interbody fusion for cervical disc syndrome. Bull Johns Hopkins Hosp 96:223–224
94.
Ryan JM, Barry FP, Murphy JM, Mahon BP (2005) Mesenchymal stem cells avoid allogeneic rejection. J Inflammation 2:8
95.
Samartzis D, Shen FH, Goldberg EJ, An HS (2005) Is autograft the gold standard in achieving radiographic fusion in one-level anterior cervical discectomy and fusion with rigid anterior plate fixation? Spine 30:1756–1761PubMed
96.
Sarwat AM, O’Brien JP, Renton P, Sutcliffe JC (2001) The use of allograft (and avoidance of autograft) in anterior lumbar interbody fusion: a critical analysis. Eur Spine J 10:237–241PubMedCentralPubMed
97.
Schaffler MB, Burr DB (1988) Stiffness of compact bone: effects of porosity and density. J Biomech 21:13–16PubMed
98.
Schultz A (1987) Loads on the lumbar spine. In: Jason MIV (ed) The lumbar spine and back pain. Churchill Livingstone, Edinburgh, pp 204–214
99.
Schwartz CE, Martha JF, Kowalski P, Wang DA, Bode R, Li L, Kim DH (2009) Prospective evaluation of chronic pain associated with posterior autologous iliac crest bone graft harvest and its effect on postoperative outcome. Health Qual Life Outcomes 7:49PubMedCentralPubMed
100.
Shad A, Leach JCD, Teddy PJ, Cadoux-Hudson TAD (2005) Use of the Solis cage and local autologous bone graft for anterior cervical discectomy and fusion: early technical experience. J Neurosurg Spine 2:116–122PubMed
101.
Shields LBE, Raque GH, Glassman SD, Campbell M, Vitaz T, Harpring J, Shields CB (2006) Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion. Spine 31:542–547PubMed
102.
Shors EC (2003) The development of coralline porous ceramic bone. In: Laurencin CT (ed) Bone graft substitutes. ASTM International, West Conshohocken, pp 271–288
103.
Silber JS, Anderson DG, Daffner SD, Brislin BT, Leland JM, Hilibrand AS, Vaccaro AR, Albert TJ (2003) Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine 28:134–139PubMed
104.
Smucker JD, Rhee JM, Singh K, Yoon ST, Heller JG (2006) Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine. Spine 31:2813–2819PubMed
105.
Stauffer RN, Coventry MB (1972) Anterior interbody lumbar spine fusion. Analysis of Mayo Clinic series. J Bone Joint Surg Am 54:756–768PubMed
106.
Suchomel P, Barsa P, Buchvald P, Svobodnik A, Vanickova E (2004) Autologous versus allogenic bone grafts in instrumented anterior cervical discectomy and fusion: a prospective study with respect to bone union pattern. Eur Spine J 13:510–515PubMedCentralPubMed
107.
Thalgott JS, Fogarty ME, Giuffre JM, Christenson SD, Epstein AK, Aprill C (2009) A prospective, randomized, blinded, single-site study to evaluate the clinical and radiographic differences between frozen and freeze-dried allograft when used as part of a circumferential anterior lumbar interbody fusion procedure. Spine 34:1251–1256PubMed
108.
Thalgott JS, Giuffre JM, Klezl Z, Timlin M (2002) Anterior lumbar interbody fusion with titanium mesh cages, coralline hydroxyapatite, and demineralized bone matrix as part of a circumferential fusion. Spine J: Official Journal of the North American Spine Society 2:63–69
109.
Thalgott JS, Klezl Z, Timlin M, Giuffre JM (2002) Anterior lumbar interbody fusion with processed sea coral (coralline hydroxyapatite) as part of a circumferential fusion. Spine 27:E518–E525, discussion E526–517PubMed
110.
Thalgott JS, Xiongsheng C, Giuffre JM (2003) Single stage anterior cervical reconstruction with titanium mesh cages, local bone graft, and anterior plating. Spine J: Official Journal of the North American Spine Society 3:294–300
111.
Thawani JP, Wang AC, Than KD, Lin C-Y, La Marca F, Park P (2010) Bone morphogenetic proteins and cancer: review of the literature. Neurosurgery 66:233–246, discussion 246PubMed
112.
Topuz K, Colak A, Kaya S, Simsek H, Kutlay M, Demircan MN, Velioglu M (2009) Two-level contiguous cervical disc disease treated with peek cages packed with demineralized bone matrix: results of 3-year follow-up. Eur Spine J 18:238–243PubMedCentralPubMed
113.
Toth JM, Boden SD, Burkus JK, Badura JM, Peckham SM, McKay WF (2009) Short-term osteoclastic activity induced by locally high concentrations of recombinant human bone morphogenetic protein-2 in a cancellous bone environment. Spine 34:539–550PubMed
114.
Tumialan LM, Pan J, Rodts GE, Mummaneni PV (2008) The safety and efficacy of anterior cervical discectomy and fusion with polyetheretherketone spacer and recombinant human bone morphogenetic protein-2: a review of 200 patients. J Neurosurg Spine 8:529–535PubMed
115.
Urist MR (1965) Bone: formation by autoinduction. Science 150:893–899PubMed
116.
Vaccaro AR, Lawrence JP, Patel T, Katz LD, Anderson DG, Fischgrund JS, Krop J, Fehlings MG, Wong D (2008) The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis: a long-term (>4 years) pivotal study. Spine 33:2850–2862PubMed
117.
Vaidya R, Carp J, Sethi A, Bartol S, Craig J, Les CM (2007) Complications of anterior cervical discectomy and fusion using recombinant human bone morphogenetic protein-2. Eur Spine J 16:1257–1265PubMedCentralPubMed
118.
Vaidya R, Weir R, Sethi A, Meisterling S, Hakeos W, Wybo CD (2007) Interbody fusion with allograft and rhBMP-2 leads to consistent fusion but early subsidence. J Bone Joint Surg Br 89:342–345PubMed
119.
van den Bent MJ, Oosting J, Wouda EJ, van Acker RE, Ansink BJ, Braakman R, van den Bent MJ, Oosting J, Wouda EJ, van Acker RE, Ansink BJ, Braakman R (1996) Anterior cervical discectomy with or without fusion with acrylate. A randomized trial. Spine 21:834–839, discussion 840PubMed
120.
Wang JC, Kanim LEA, Yoo S, Campbell PA, Berk AJ, Lieberman JR (2003) Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats. J Bone Joint Surg Am 85-A:905–911 (Erratum appears in J Bone Joint Surg Am. 2003 Sep;85-A(9):1801)PubMed
121.
Wang JC, Zou D, Yuan H, Yoo J (1998) A biomechanical evaluation of graft loading characteristics for anterior cervical discectomy and fusion. A comparison of traditional and reverse grafting techniques. Spine 23:2450–2454PubMed
122.
123.
Whitmore RG, Schwartz JS, Simmons S, Stein SC, Ghogawala Z (2012) Performing a cost analysis in spine outcomes research: comparing ventral and dorsal approaches for cervical spondylotic myelopathy. Neurosurgery 70:860–867, discussion 867PubMed
124.
Wittenberg RH, Moeller J, Shea M, White AA 3rd, Hayes WC (1990) Compressive strength of autologous and allogenous bone grafts for thoracolumbar and cervical spine fusion. Spine 15:1073–1078PubMed
125.
Yamada S, Heymann D, Bouler JM, Daculsi G (1997) Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite/beta-tricalcium phosphate ratios. Biomaterials 18:1037–1041PubMed
126.
Zdeblick TA, Ducker TB (1991) The use of freeze-dried allograft bone for anterior cervical fusions. Spine 16:726–729PubMed
127.
Zhang Y, Homsi D, Gates K, Oakes K, Sutherland V, Wolfinbarger L Jr (1994) A comprehensive study of physical parameters, biomechanical properties, and statistical correlations of iliac crest bone wedges used in spinal fusion surgery. IV. Effect of gamma irradiation on mechanical and material properties. Spine 19:304–308PubMed
128.
Zigler J, Delamarter R, Spivak JM, Linovitz RJ, Danielson GO 3rd, Haider TT, Cammisa F, Zuchermann J, Balderston R, Kitchel S, Foley K, Watkins R, Bradford D, Yue J, Yuan H, Herkowitz H, Geiger D, Bendo J, Peppers T, Sachs B, Girardi F, Kropf M, Goldstein J (2007) Results of the prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement versus circumferential fusion for the treatment of 1-level degenerative disc disease. Spine 32:1155–1162, discussion 1163PubMed
Metadata
Title
Current status of bone graft options for anterior interbody fusion of the cervical and lumbar spine
Authors
Anthony Minh Tien Chau
Lileane Liang Xu
Johnny Ho-Yin Wong
Ralph Jasper Mobbs
Publication date
01-01-2014
Publisher
Springer Berlin Heidelberg
Published in
Neurosurgical Review / Issue 1/2014
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI
https://doi.org/10.1007/s10143-013-0483-9

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