Published in:
01-04-2011 | Short Communication
Cumulative glycaemia as measured by lens fluorometry: association with retinopathy in type 2 diabetes
Published in: Diabetologia | Issue 4/2011
Login to get accessAbstract
Aims/hypothesis
The aim of this study was to assess the association between lifelong cumulative glycaemia estimated by lens fluorometry and the presence of retinopathy in individuals with type 2 diabetes.
Methods
We carried out a cross-sectional population-based study of 970 participants aged between 30 and 60 years, of which 170 were diagnosed with diabetes on screening (WHO 1999 criteria) and 35 had known type 2 diabetes. Procedures included clinical and laboratory examinations, non-invasive assessment of the intrinsic fluorescence of the lens of the eye, and seven-field fundus photography.
Results
Retinopathy was found in 46 (22%) of 205 participants with type 2 diabetes. In a logistic regression analysis controlling for age, sex and diabetes status (screen-detected or known), a two-fold increase in lens fluorescence increased the odds for retinopathy by 3.46 (95% CI 1.25–9.55, p = 0.017). The association was marginally significant (OR 3.00 [95% CI 1.00–9.01], p = 0.050) when also adjusted for smoking, systolic blood pressure, body mass index and HbA1c.
Conclusions/interpretation
Diabetic retinopathy was related to cumulative lifelong glycaemia as estimated by lens fluorometry in participants with type 2 diabetes. This supports the hypothesis that retinopathy is a marker of lifelong elevated glycaemia as well as of the unknown, pre-diagnostic duration of type 2 diabetes. The powerful association between lens fluorescence and retinopathy underscores the importance of strict long-term glycaemic control in the prevention of retinopathy in people with diabetes.