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European Radiology
Published in: European Radiology 2/2018

01-02-2018 | Gastrointestinal

CT Perfusion evaluation of gastric cancer: correlation with histologic type

Authors: Dong Ho Lee, Se Hyung Kim, Ijin Joo, Joon Koo Han

Published in: European Radiology | Issue 2/2018

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Abstract

Objectives

To prospectively evaluate if the perfusion parameters of gastric cancer can provide information on histologic subtypes of gastric cancer.

Methods

We performed preoperative perfusion CT (PCT) and curative gastrectomy in 46 patients. PCT data were analysed using a dedicated software program. Perfusion parameters were obtained by two independent radiologists and were compared according to histologic type using Kruskal–Wallis, Mann–Whitney U test and receiver operating characteristic analysis. To assess inter-reader agreement, we used intraclass correlation coefficient (ICC).

Results

Inter-reader agreement for perfusion parameters was moderate to substantial (ICC = 0.585–0.678). Permeability surface value of poorly cohesive carcinoma (PCC) was significantly higher than other histologic types (47.3 ml/100 g/min in PCC vs 26.5 ml/100 g/min in non-PCC, P < 0.001). Mean transit time (MTT) of PCC was also significantly longer than non-PCC (13.0 s in PCC vs 10.3 s in non-PCC, P = 0.032). The area under the curve to predict PCC was 0.891 (P < 0.001) for permeability surface and 0.697 (P = 0.015) for MTT.

Conclusion

Obtaining perfusion parameters from PCT was feasible in gastric cancer patients and can aid in the preoperative imaging diagnosis of PCC-type gastric cancer as the permeability surface and MTT value of PCC type gastric cancer were significantly higher than those of non-PCC.

Key points

• Obtaining perfusion parameters from PCT was feasible in patients with gastric cancer.
• Permeability surface and MTT were significantly higher in poorly cohesive carcinoma (PCC).
• Permeability surface, MTT can aid in the preoperative imaging diagnosis of PCC.
Appendix
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Metadata
Title
CT Perfusion evaluation of gastric cancer: correlation with histologic type
Authors
Dong Ho Lee
Se Hyung Kim
Ijin Joo
Joon Koo Han
Publication date
01-02-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 2/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-4979-5

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