Top

Published in:

01-04-2010 | Case Report

CT and MRI findings with histopathologic correlation of a unique bilateral orbital mantle cell lymphoma in Graves’ disease: a case report and brief review of literature

Authors: Asif Abdullah, Haitham Elsamaloty, Yogesh Patel, Jennifer Chang

Published in: Journal of Neuro-Oncology | Issue 2/2010

Abstract

Bilateral orbital mantle cell lymphoma is rare. We present an unusual case report of a patient with Graves’ disease and no previous history of lymphoma, who was found to have bilateral orbital mantle cell lymphoma on CT and MR imaging which was confirmed histopathologically. To our knowledge, there have been no previously described cases of bilateral mantle cell lymphoma in Graves’ disease. Of particular radiologic interest, the left orbital mass presented in a bicompartmental fashion with a discreet intraconal component separated by a fat plane from an extraconal component that extended intraconally. In our review of radiologic literature, this presentation has not been described previously.

Rey-Porca C, Perez-Encinas M, Gonzalez F (2008) Orbital lymphomas presentation of nine cases. Arch Soc Esp Oftalmol 83:95–104PubMedCrossRef

Coupland SE, Hummel M, Stein H (2002) Ocular adnexal lymphomas: five case presentations and a review of the literature. Surv Ophthalmol 47:470–490CrossRefPubMed

Ferry JA, Fung CY, Zukerberg L et al (2007) Lymphoma of the ocular adnexa: a study of 353 cases. Am J Surg Pathol 31(2):170–184CrossRefPubMed

Ben Simon GJ, Annunziata CC, Fink J et al (2005) Rethinking orbital imaging establishing guidelines for interpreting orbital imaging studies, evaluating their predictive value in patients with orbital tumors. Ophthalmology 112(12):2196–2207CrossRefPubMed

Forbes GS, Earnest F IV, Waller RR (1982) Computed tomography of orbital tumors, including late-generation scanning techniques. Radiology 142(2):387–394PubMed

Morice WG, Kurtin PJ, Hodnefield JM et al (2008) Predictive value of blood, bone marrow flow cytometry in B-cell lymphoma classification: comparative analysis of flow cytometry, tissue biopsy in 252 patients. Mayo Clin Pro 83(7):776–785CrossRef

Looi A, Gascoyne RD, Chhnaabhai M, Connors JM, Rootman J, White VA (2005) Mantle cell lymphoma in the ocular adnexal region. Opthalamalogy 112(1):114–119CrossRef

Stark JJ, Newsom RW, Roman J (2005) Orbital MALT lymphoma in a patient with graves’ ophthalmopathy: a unique observation. Cancer Invest 223(7):593–595CrossRef

Nutting CM, Shah-Desai S, Rose GE, Norton AP, Plowman PN (2006) Thyroid orbitopathy possibly predisposes to late-onset of periocular lymphoma. Eye 20(6):645–648CrossRefPubMed

10.

Boyce PJ (1998) Orbital lymphoma masquerading as thyroid ophthalmopathy. J Am Optom Assoc 69(10):666–673PubMed

11.

Bartalena L, Brogioni S, Valeriano R et al (1995) Non-autoimmune hyperthyroidism associated with isolated bilateral ocular lymphoma mimicking Graves’ disease with ophthalmopathy: a cause of misdiagnosis. J Endocrinol Invest 18(10):817–819PubMed

12.

Buescu A, Teixeira P, Coelho S et al (2001) Orbital lymphoma misdiagnosed as Graves’ ophthalmopathy. Endocr Pract 7(2):110–112PubMed

13.

Payne JF, Shields CL, Eagle RC Jr et al (2006) Orbital lymphoma simulating thyroid orbitopathy. Ophthal Plast Reconstr Surg 22(4):302–304CrossRefPubMed

14.

Decaudin D, de Cremoux P, Vincent-Salomon A et al (2006) Ocular adnexal lymphoma: a review of clinicopathologic features and treatment options. Blood 108:1451–1460CrossRefPubMed

15.

Meunier J, Lumbroso-Le Rouic L, Vincent-Salomon A et al (2004) Ophthalmologic, intraocular non-Hodgkin’s lymphoma: a large single centre study of initial characteristics, natural history, prognostic factors. Hematol Oncol 22(4):143–158CrossRefPubMed

16.

Sullivan TJ, Valenzuela AA (2006) Imaging features of ocular adnexal lymphoproliferative disease. Eye 20(10):1189–1195CrossRefPubMed

17.

Akansel G, Hendrix L, Erickson BA et al (2005) MRI patterns in orbital malignant lymphoma, atypical lymphocytic infiltrates. Eur J Radiol 53(2):175–181CrossRefPubMed

18.

Polito E, Galieni P, Leccisotti A (1996) Clinical radiological presentation of 95 orbital lymphoid tumors. Graefes Arch Clin Exp Ophthalmol 234(8):504–509CrossRefPubMed

19.

Westacott S, Garner A, Moseley IF et al (1991) Orbital lymphoma versus reactive lymphoid hyperplasia: an analysis of the use of computed tomography in differential diagnosis. Br J Ophthalmol 75(12):722–725CrossRefPubMed

20.

Forbes GS, Sheedy PF II, Waller RR (1980) Orbital tumors evaluated by computed tomography. Radiology 136(1):101–111PubMed

21.

Gulfer H, Laubenberger J, Gerling J, Nesbitt LG, Langer M (1997) MRI of lymphomas of the orbits and the paranasal sinuses. J Comput Assist Tomogr 21(6):887–891CrossRef

Title: CT and MRI findings with histopathologic correlation of a unique bilateral orbital mantle cell lymphoma in Graves’ disease: a case report and brief review of literature
Authors: Asif Abdullah
Haitham Elsamaloty
Yogesh Patel
Jennifer Chang
Publication date: 01-04-2010
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2010
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-009-0019-x

At a glance: The STEP trials

Springer Medicine

CT and MRI findings with histopathologic correlation of a unique bilateral orbital mantle cell lymphoma in Graves’ disease: a case report and brief review of literature

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2010

Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumor

The cell growth inhibitory transcription factor C/EBPδ is expressed in human meningiomas in association with low histological grade and proliferation index

Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm: a report of two cases

Lenalidomide stops progression of multifocal epithelioid hemangioendothelioma including intracranial disease

In vivo evaluation of intracellular drug-nanocarriers infused into intracranial tumours by convection-enhanced delivery: distribution and radiosensitisation efficacy

Feasibility, safety, and outcome of frameless image-guided robotic radiosurgery for brain metastases