Published in:
01-08-2013 | Case Report
CSF viral escape in a patient with HIV-associated neurocognitive disorder
Authors:
Michael N. Khoury, C. Sabrina Tan, Marcia Peaslee, Igor J. Koralnik
Published in:
Journal of NeuroVirology
|
Issue 4/2013
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Excerpt
HIV-associated neurocognitive disorder (HAND) is a condition that encompasses cognitive deficits as well as motor symptoms. HIV is thought to enter the CNS early at the time of primary infection by crossing the blood brain barrier. The virus primarily infects perivascular macrophages and microglia (both of which express CD4); while the neurons, which do not express CD4, sustain injury secondary to the resulting inflammation (Gonzalez-Scarano and Martin-Garcia
2005). HAND MRI findings classically include symmetric, periventricular hyperintense lesions on T2-weighted sequences. …