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01-02-2014 | Experimental

Crystal analyser-based X-ray phase contrast imaging in the dark field: implementation and evaluation using excised tissue specimens

Authors: Masami Ando, Naoki Sunaguchi, Yanlin Wu, Synho Do, Yongjin Sung, Abner Louissaint, Tetsuya Yuasa, Shu Ichihara, Rajiv Gupta

Published in: European Radiology | Issue 2/2014

Abstract

Objectives

We demonstrate the soft tissue discrimination capability of X-ray dark-field imaging (XDFI) using a variety of human tissue specimens.

Methods

The experimental setup for XDFI comprises an X-ray source, an asymmetrically cut Bragg-type monochromator-collimator (MC), a Laue-case angle analyser (LAA) and a CCD camera. The specimen is placed between the MC and the LAA. For the light source, we used the beamline BL14C on a 2.5-GeV storage ring in the KEK Photon Factory, Tsukuba, Japan.

Results

In the eye specimen, phase contrast images from XDFI were able to discriminate soft-tissue structures, such as the iris, separated by aqueous humour on both sides, which have nearly equal absorption. Superiority of XDFI in imaging soft tissue was further demonstrated with a diseased iliac artery containing atherosclerotic plaque and breast samples with benign and malignant tumours. XDFI on breast tumours discriminated between the normal and diseased terminal duct lobular unit and between invasive and in-situ cancer.

Conclusions

X-ray phase, as detected by XDFI, has superior contrast over absorption for soft tissue processes such as atherosclerotic plaque and breast cancer.

Key points

• X-ray dark field imaging (XDFI) can dramatically increase sensitivity of phase detection.

• XDFI can provide enhanced soft tissue discrimination.

• With XDFI, abnormal anatomy can be visualised with high spatial/contrast resolution.

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Title: Crystal analyser-based X-ray phase contrast imaging in the dark field: implementation and evaluation using excised tissue specimens
Authors: Masami Ando
Naoki Sunaguchi
Yanlin Wu
Synho Do
Yongjin Sung
Abner Louissaint
Tetsuya Yuasa
Shu Ichihara
Rajiv Gupta
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 2/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-013-3021-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Crystal analyser-based X-ray phase contrast imaging in the dark field: implementation and evaluation using excised tissue specimens

Abstract

Objectives

Methods

Results

Conclusions

Key points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key points

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