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Published in: Pediatric Nephrology 5/2008

01-05-2008 | Brief Report

Cryptococcosis associated with crescentic glomerulonephritis

Authors: Marta Suárez-Rivera, Rania A. Abadeer, Marylee M. Kott, Michael C. Braun

Published in: Pediatric Nephrology | Issue 5/2008

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Abstract

Crescentic glomerulonephritis (CGN) is an uncommon form of renal injury in childhood. Whereas many infectious processes are known to be linked to CGN, fungal infections typically are not. This report describes an 11-year-old girl who presented with CGN, cutaneous anergy, and cryptococcal mediastinitis. Whereas cryptococcal disease in children is usually associated with immunodeficiency (inherited or acquired), extensive immunologic evaluation of the patient was notable only for relative CD4 lymphopenia with normal CD4/CD8 ratios. Testing for human immunodeficiency virus was negative. Clinical and diagnostic studies are presented, along with a review of the literature regarding glomerular disease and cryptococcal infections.
Literature
1.
go back to reference Dillon MJ (2003) Crescentic glomerulonephritis. In: Niaudet P (ed) Pediatric Nephrology, 5th edn. Lippincott Williams and Wilkins, Philadelphia, pp 655–662. Dillon MJ (2003) Crescentic glomerulonephritis. In: Niaudet P (ed) Pediatric Nephrology, 5th edn. Lippincott Williams and Wilkins, Philadelphia, pp 655–662.
2.
go back to reference Couser WG (1998) Rapidly progressive glomerulonephritis: Classification, pathogenetic mechanisms, and therapy. Am J Kidney Dis 11:449–464CrossRef Couser WG (1998) Rapidly progressive glomerulonephritis: Classification, pathogenetic mechanisms, and therapy. Am J Kidney Dis 11:449–464CrossRef
3.
go back to reference Slater DN, Brown CB, Ward AM, Shortland JR, Nicholls AJ, Stephenson T, Moss S (1983) Immune complex crescentic glomerulonephritis associated with pulmonary aspergillosis. Histopathology 7:957–966CrossRef Slater DN, Brown CB, Ward AM, Shortland JR, Nicholls AJ, Stephenson T, Moss S (1983) Immune complex crescentic glomerulonephritis associated with pulmonary aspergillosis. Histopathology 7:957–966CrossRef
4.
go back to reference Cole BR, Brocklebank JT, Kienstra RA, Kissane JM, Robson AM (1976) "Pulse" methylprednisolone therapy in the treatment of severe glomerulonephritis. J Pediatr 88:307–314CrossRef Cole BR, Brocklebank JT, Kienstra RA, Kissane JM, Robson AM (1976) "Pulse" methylprednisolone therapy in the treatment of severe glomerulonephritis. J Pediatr 88:307–314CrossRef
5.
go back to reference Khawcharoenporn T, Apisarnthanarak A, Mundy LM (2007) Non-neoformans cryptococcal infections: A systematic review. Infection 35:51–58CrossRef Khawcharoenporn T, Apisarnthanarak A, Mundy LM (2007) Non-neoformans cryptococcal infections: A systematic review. Infection 35:51–58CrossRef
6.
go back to reference Sweeney DA, Caserta MT, Korones DN, Casadevall A, Goldman DL (2003) A ten-year-old boy with a pulmonary nodule secondary to cryptococcus neoformans: Case report and review of the literature. Pediatr Infect Dis J 22:1089–1093CrossRef Sweeney DA, Caserta MT, Korones DN, Casadevall A, Goldman DL (2003) A ten-year-old boy with a pulmonary nodule secondary to cryptococcus neoformans: Case report and review of the literature. Pediatr Infect Dis J 22:1089–1093CrossRef
7.
go back to reference Zhou Q, Murphy WJ (2006) Immune response and immunotherapy to cryptococcus infections. Immunol Res 35:191–208CrossRef Zhou Q, Murphy WJ (2006) Immune response and immunotherapy to cryptococcus infections. Immunol Res 35:191–208CrossRef
8.
go back to reference Shoham S, Levitz SM (2005) The immune response to fungal infections. Br J Haematol 129:569–582CrossRef Shoham S, Levitz SM (2005) The immune response to fungal infections. Br J Haematol 129:569–582CrossRef
9.
go back to reference Kozel TR, Wilson MA, Murphy JW (1991) Early events in initiation of alternative complement pathway activation by the capsule of cryptococcus neoformans. Infect Immun 59:3101–3110PubMedPubMedCentral Kozel TR, Wilson MA, Murphy JW (1991) Early events in initiation of alternative complement pathway activation by the capsule of cryptococcus neoformans. Infect Immun 59:3101–3110PubMedPubMedCentral
10.
go back to reference Tanaka S, Teraguchi M, Hasui M, Taniuchi S, Ikemoto Y, Kobayashi Y (2004) Idiopathic CD4+ T-lymphocytopenia in a boy with Down syndrome. report of a patient and a review of the literature. Eur J Pediatr 163:122–123CrossRef Tanaka S, Teraguchi M, Hasui M, Taniuchi S, Ikemoto Y, Kobayashi Y (2004) Idiopathic CD4+ T-lymphocytopenia in a boy with Down syndrome. report of a patient and a review of the literature. Eur J Pediatr 163:122–123CrossRef
11.
go back to reference Huang XR, Tipping PG, Apostolopoulos J, Oettinger C, D’Souza M, Milton G, Holdsworth SR (1997) Mechanisms of T cell-induced glomerular injury in anti-glomerular basement membrane (GBM) glomerulonephritis in rats. Clin Exp Immunol 109:134–142CrossRef Huang XR, Tipping PG, Apostolopoulos J, Oettinger C, D’Souza M, Milton G, Holdsworth SR (1997) Mechanisms of T cell-induced glomerular injury in anti-glomerular basement membrane (GBM) glomerulonephritis in rats. Clin Exp Immunol 109:134–142CrossRef
12.
go back to reference Huang XR, Tipping PG, Shuo L, Holdsworth SR (1997) Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice. Kidney Int 51:94–103CrossRef Huang XR, Tipping PG, Shuo L, Holdsworth SR (1997) Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice. Kidney Int 51:94–103CrossRef
13.
go back to reference Nakayama M, Hori K, Ishida I, Masutani K, Katafuchi R (2005) A case of necrotizing glomerulonephritis presenting with nephrotic syndrome associated with pulmonary cryptococcosis. Clin Exp Nephrol 9:74–78CrossRef Nakayama M, Hori K, Ishida I, Masutani K, Katafuchi R (2005) A case of necrotizing glomerulonephritis presenting with nephrotic syndrome associated with pulmonary cryptococcosis. Clin Exp Nephrol 9:74–78CrossRef
Metadata
Title
Cryptococcosis associated with crescentic glomerulonephritis
Authors
Marta Suárez-Rivera
Rania A. Abadeer
Marylee M. Kott
Michael C. Braun
Publication date
01-05-2008
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 5/2008
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-007-0732-7

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