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Supportive Care in Cancer
Published in: Supportive Care in Cancer 5/2020

01-05-2020 | Cryotherapy | Special Article

Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines

Authors: M Elvira P Correa, Karis Kin Fong Cheng, Karen Chiang, Abhishek Kandwal, Charles L Loprinzi, Takehiko Mori, Carin Potting, Tanya Rouleau, Juan J Toro, Vinisha Ranna, Anusha Vaddi, Douglas E Peterson, Paolo Bossi, Rajesh V Lalla, Sharon Elad

Published in: Supportive Care in Cancer | Issue 5/2020

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Abstract

Purpose

To update the 2013 Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) clinical practice guidelines on oral cryotherapy for the management of oral mucositis (OM) caused by cancer therapies.

Methods

A systematic review was conducted by the Mucositis Study Group of MASCC/ISOO. The evidence for each intervention for specific cancer treatment modalities was assigned a level of evidence (LoE). The findings were added to the database used to develop the 2013 MASCC/ISOO clinical practice guidelines. Based on the LoE, the guidelines were set as: recommendation, suggestion, or no guideline possible.

Results

A total of 114 papers were identified: 44 from PubMed and 70 from Web of Science. After abstract triage and merging with the 2013 database, 36 papers were reviewed. The LoE for prevention of OM with oral cryotherapy in patients undergoing autologous hematopoietic stem cell transplant using high-dose melphalan conditioning protocols was upgraded, and the guideline changed to recommendation. Additionally, the recommendation for prevention of OM with oral cryotherapy in patients receiving bolus 5-fluorouracil for the treatment of solid tumors was confirmed. No guidelines were possible for other clinical settings.

Conclusions

The evidence supports recommendations for the use of oral cryotherapy for the prevention of OM for either (i) patients undergoing autologous hematopoietic stem cell transplant with high-dose melphalan conditioning protocols or (ii) patients receiving bolus 5-fluorouracil chemotherapy.
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Metadata
Title
Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines
Authors
M Elvira P Correa
Karis Kin Fong Cheng
Karen Chiang
Abhishek Kandwal
Charles L Loprinzi
Takehiko Mori
Carin Potting
Tanya Rouleau
Juan J Toro
Vinisha Ranna
Anusha Vaddi
Douglas E Peterson
Paolo Bossi
Rajesh V Lalla
Sharon Elad
Publication date
01-05-2020
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 5/2020
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-019-05217-x

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