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CardioVascular and Interventional Radiology
Published in: CardioVascular and Interventional Radiology 10/2016

01-10-2016 | Clinical Investigation

Cryoablation of Hepatocellular Carcinoma with High-Risk for Percutaneous Ablation: Safety and Efficacy

Authors: Gyoung Min Kim, Jong Yun Won, Man Deuk Kim, Sung Il Park, Do Yun Lee, Wonseon Shin, Minwoo Shin, Kwang-Hyub Han, Do Young Kim, Seung Up Kim

Published in: CardioVascular and Interventional Radiology | Issue 10/2016

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Abstract

Purpose

The aim of this study was to evaluate the safety and effectiveness of cryoablation in the treatment of subcapsular hepatocellular carcinoma (HCC) adjacent to various organs.

Materials and Methods

Twenty-eight patients with subcapsular HCC were treated with cryoablation in our institution. The degree of peri-procedural pain was measured using the visual analog scale (VAS). Technical success, local tumor progression, and overall disease progression rates were calculated. Procedure-related complications were identified by reviewing electronic medical records. Biochemical data, including serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin levels before and after the procedure were collected.

Results

Subcapsular HCC tumors were located near the gallbladder, colon, stomach, kidney, diaphragm, or abdominal wall. The technical success rate of cryoablation was 96.4 % (27/28). Local recurrence- and progression-free survival rates were 96 and 84 % at 6 months, and 82 and 43 % at 1 year, respectively. All patients survived during the follow-up period. The VAS pain score ranged from 0 to 3 (mean, 1.57). A major complication occurred in one patient (3.6 %) and minor complications occurred at a rate of 17.9 %. Transient elevations of serum AST, ALT, and bilirubin levels were observed.

Conclusion

Cryoablation is a safe and an effective procedure for the treatment of subcapsular HCC adjacent to various major organs.
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Metadata
Title
Cryoablation of Hepatocellular Carcinoma with High-Risk for Percutaneous Ablation: Safety and Efficacy
Authors
Gyoung Min Kim
Jong Yun Won
Man Deuk Kim
Sung Il Park
Do Yun Lee
Wonseon Shin
Minwoo Shin
Kwang-Hyub Han
Do Young Kim
Seung Up Kim
Publication date
01-10-2016
Publisher
Springer US
Published in
CardioVascular and Interventional Radiology / Issue 10/2016
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-016-1384-4

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