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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
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Molecular Cancer
Published in: Molecular Cancer 1/2024

Open Access 01-12-2024 | Review

Crosstalk between metabolism and cell death in tumorigenesis

Authors: Shichao Yang, Caden Hu, Xiaomei Chen, Yi Tang, Juanjuan Li, Hanqing Yang, Yi Yang, Binwu Ying, Xue Xiao, Shang‑Ze Li, Li Gu, Yahui Zhu

Published in: Molecular Cancer | Issue 1/2024

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Abstract

It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid proliferation rate, cancer cells constantly encounter the limits of insufficient oxygen and nutrient supplies. To satisfy their growth needs and resist adverse environmental events, tumor cells modify the metabolic pathways to produce both extra energies and substances required for rapid growth. Realizing the metabolic characters special for tumor cells will be helpful for eliminating them during therapy. Cell death is a hot topic of long-term study and targeting cell death is one of the most effective ways to repress tumor growth. Many studies have successfully demonstrated that metabolism is inextricably linked to cell death of cancer cells. Here we summarize the recently identified metabolic characters that specifically impact on different types of cell deaths and discuss their roles in tumorigenesis.
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Metadata
Title
Crosstalk between metabolism and cell death in tumorigenesis
Authors
Shichao Yang
Caden Hu
Xiaomei Chen
Yi Tang
Juanjuan Li
Hanqing Yang
Yi Yang
Binwu Ying
Xue Xiao
Shang‑Ze Li
Li Gu
Yahui Zhu
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2024
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-024-01977-1

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