Skip to main content
Top
Published in: International Journal of Colorectal Disease 12/2007

01-12-2007 | Case Report

Crohn’s disease-associated colorectal cancer in Japan: report of four cases

Authors: Tadataka Hayashi, Toshio Nakamura, Kiyotaka Kurachi, Atsuko Fukazawa, Akihito Nakajima, Koichi Nakamura, Shohachi Suzuki, Hiroyuki Konno

Published in: International Journal of Colorectal Disease | Issue 12/2007

Login to get access

Abstract

Purpose

We report four cases of Crohn’s disease (CD)-associated colorectal cancer (CRC) in our department.

Case 1

A 42-year-old Japanese man had a 14-year history of ileocolon CD. He had a history of an ileocecal resection and a stricture plasty. At the age of 42, sigmoid colostomy was performed because of the deterioration of the anal stenosis. After this operation, the perianal pain had remained, and a magnetic resonance imaging scan revealed a rectal tumor.

Case 2

A 30-year-old Japanese man had a 13-year history of ileocolon CD. He had a history of an ileostomy, a subtotal colectomy, and ileo-rectal anastomosis. At the age of 30, he had perianal pain, and a colonoscopy revealed a rectal cancer. An abdomino-perineal resection of the remnant rectum was performed.

Case 3

A 46-year-old Japanese man had a 9-year history of ileocolon CD. He experienced abdominal fullness. Colonoscopy revealed an ascending colon cancer. He underwent a subtotal colectomy and ileo-rectal anastomosis.

Case 4

A 33-year-old Japanese woman had a 16-year history of ileocolon CD. She had no changes in symptoms of CD. Surveillance colonoscopy revealed a transverse colon cancer. She underwent a subtotal colectomy and ileo-rectal anastomosis.

Conclusion

As the number of patients with CD and with CD-associated CRC has increased in Japan, CD-associated CRC, as noted in these patients, should be kept in mind in the management of patients with CD. In addition, a surveillance system of patients with CD should be established and should prompt further study about CD-associated CRC.
Literature
1.
go back to reference Ekbom A, Adami HO, Helmick C, Zack M (1990) Increased risk of large-bowel cancer in Crohn’s disease with colonic involvement. Lancet 336:357–359CrossRefPubMed Ekbom A, Adami HO, Helmick C, Zack M (1990) Increased risk of large-bowel cancer in Crohn’s disease with colonic involvement. Lancet 336:357–359CrossRefPubMed
3.
go back to reference Bernstein CN, Blanchard JF, Kliewer E, Wajda A (2001) Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer 91:854–862CrossRefPubMed Bernstein CN, Blanchard JF, Kliewer E, Wajda A (2001) Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer 91:854–862CrossRefPubMed
4.
go back to reference Larsen M, Mose H, Gislum M, Skriver MV, Jepsen P, Nørgård B, Sørensen HT (2007) Survival after colorectal cancer in patients with Crohn’s disease: a nationwide population-based Danish follow-up study. Am J Gastroenterol 102:163–167CrossRefPubMed Larsen M, Mose H, Gislum M, Skriver MV, Jepsen P, Nørgård B, Sørensen HT (2007) Survival after colorectal cancer in patients with Crohn’s disease: a nationwide population-based Danish follow-up study. Am J Gastroenterol 102:163–167CrossRefPubMed
5.
6.
go back to reference Gyde SN, Prior P, Thompson H, Waterhouse JA, Allan RN (1984) Survival of patients with colorectal cancer complicating ulcerative colitis. Gut 25:228–231CrossRefPubMedPubMedCentral Gyde SN, Prior P, Thompson H, Waterhouse JA, Allan RN (1984) Survival of patients with colorectal cancer complicating ulcerative colitis. Gut 25:228–231CrossRefPubMedPubMedCentral
7.
go back to reference Choi PM, Zelig MP (1994) Similarity of colorectal cancer in Crohn’s disease and ulcerative colitis: Implications for carcinogenesis and prevention. Gut 35:950–954CrossRefPubMedPubMedCentral Choi PM, Zelig MP (1994) Similarity of colorectal cancer in Crohn’s disease and ulcerative colitis: Implications for carcinogenesis and prevention. Gut 35:950–954CrossRefPubMedPubMedCentral
8.
go back to reference Canavan C, Abrams KR, Mayberry J (2006) Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn’s disease. Aliment Pharmacol Ther 23:1097–1104CrossRefPubMed Canavan C, Abrams KR, Mayberry J (2006) Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn’s disease. Aliment Pharmacol Ther 23:1097–1104CrossRefPubMed
9.
go back to reference Svrcek M, Cosnes J, Beaugerie L, Parc R, Bennis M, Tiret E, Fléjou JF (2007) Colorectal neoplasia in Crohn’s colitis: a retrospective comparative study with ulcerative colitis. Histopathology 50:574–583CrossRefPubMed Svrcek M, Cosnes J, Beaugerie L, Parc R, Bennis M, Tiret E, Fléjou JF (2007) Colorectal neoplasia in Crohn’s colitis: a retrospective comparative study with ulcerative colitis. Histopathology 50:574–583CrossRefPubMed
10.
go back to reference Loftus EV (2004) Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 126:1504–1517CrossRefPubMed Loftus EV (2004) Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 126:1504–1517CrossRefPubMed
11.
go back to reference Yao T, Matsui T, Hiwatashi N (2000) Crohn’s disease in Japan: diagnostic criteria and epidemiology. Dis Colon Rectum 43:S85–S93CrossRefPubMed Yao T, Matsui T, Hiwatashi N (2000) Crohn’s disease in Japan: diagnostic criteria and epidemiology. Dis Colon Rectum 43:S85–S93CrossRefPubMed
12.
go back to reference Maykel JA, Hagerman G, Mellgren AF, Li SY, Alavi K, Baxter NN, Madoff RD (2006) Crohn’s colitis: the incidence of dysplasia and adenocarcinoma in surgical patients. Dis Colon Rectum 49:950–957CrossRefPubMed Maykel JA, Hagerman G, Mellgren AF, Li SY, Alavi K, Baxter NN, Madoff RD (2006) Crohn’s colitis: the incidence of dysplasia and adenocarcinoma in surgical patients. Dis Colon Rectum 49:950–957CrossRefPubMed
14.
go back to reference Makiyama K, Itsuno M (1992) Cancer in Crohn’s disease with reference to malignant change and early diagnosis (in Japanese without English abstract). Sogo Rinsho 41:285–290 Makiyama K, Itsuno M (1992) Cancer in Crohn’s disease with reference to malignant change and early diagnosis (in Japanese without English abstract). Sogo Rinsho 41:285–290
15.
go back to reference Mizushima T, Nezu R, Ito T, Uchikoshi F, Kai Y, Tamagawa H, Matsuda C, Yamagami Y, Inoue Y, Matsuda H (2005) Three cases of colorectal cancer in patients with Crohn’s disease. Nippon Shokakibyo Gakkai Zasshi 102:912–917PubMed Mizushima T, Nezu R, Ito T, Uchikoshi F, Kai Y, Tamagawa H, Matsuda C, Yamagami Y, Inoue Y, Matsuda H (2005) Three cases of colorectal cancer in patients with Crohn’s disease. Nippon Shokakibyo Gakkai Zasshi 102:912–917PubMed
16.
go back to reference Friedman S, Rubin PH, Bodian C, Goldstein E, Harpaz N, Present DH (2001) Screening and surveillance colonoscopy in chronic Crohn’s colitis. Gastroenterology 120:820–826CrossRefPubMed Friedman S, Rubin PH, Bodian C, Goldstein E, Harpaz N, Present DH (2001) Screening and surveillance colonoscopy in chronic Crohn’s colitis. Gastroenterology 120:820–826CrossRefPubMed
17.
go back to reference Greenstein AJ (2000) Cancer in inflammatory bowel disease. Mt Sinai J Med 67:227–240PubMed Greenstein AJ (2000) Cancer in inflammatory bowel disease. Mt Sinai J Med 67:227–240PubMed
18.
go back to reference Askling J, Dickman PW, Karlen P, Brostrom O, Lapidus A, Lofberq R, Ekbom A (2001) Family history as a risk factor for colorectal cancer in inflammatory bowel disease. Gastroenterology 120:1356–1362CrossRefPubMed Askling J, Dickman PW, Karlen P, Brostrom O, Lapidus A, Lofberq R, Ekbom A (2001) Family history as a risk factor for colorectal cancer in inflammatory bowel disease. Gastroenterology 120:1356–1362CrossRefPubMed
19.
go back to reference Siegel CA, Sands BE (2006) Risk factors for colorectal cancer in Crohn’s colitis: a case–control study. Inflamm Bowel Dis 12:491–496CrossRefPubMed Siegel CA, Sands BE (2006) Risk factors for colorectal cancer in Crohn’s colitis: a case–control study. Inflamm Bowel Dis 12:491–496CrossRefPubMed
20.
go back to reference Leighton JA, Shen B, Baron TH, Adler DG, Davila R, Egan JV, Faigel DO, Gan S, Hirota WK, Lichtenstein D, Qureshi WA, Rajan E, Zuckerman MJ, VanGuilder T, Fanelli RD (2006) ASGE guideline: endoscopy in the diagnosis and treatment of inflammatory bowel disease. Gastrointest Endosc 63:558–565CrossRefPubMed Leighton JA, Shen B, Baron TH, Adler DG, Davila R, Egan JV, Faigel DO, Gan S, Hirota WK, Lichtenstein D, Qureshi WA, Rajan E, Zuckerman MJ, VanGuilder T, Fanelli RD (2006) ASGE guideline: endoscopy in the diagnosis and treatment of inflammatory bowel disease. Gastrointest Endosc 63:558–565CrossRefPubMed
21.
go back to reference Nikias G, Eisner T, Katz S, Levin L, Eskries D, Urmacher C, McKinley M (1995) Crohn’s disease and colorectal carcinoma: rectal cancer complicating longstanding active perianal disease. Am J Gastroenterol 90:216–219PubMed Nikias G, Eisner T, Katz S, Levin L, Eskries D, Urmacher C, McKinley M (1995) Crohn’s disease and colorectal carcinoma: rectal cancer complicating longstanding active perianal disease. Am J Gastroenterol 90:216–219PubMed
22.
go back to reference Shimano T, Okuda H, Monden T, Inaji H, Mori T (1987) Usefulness of carcinoembryonic antigen measurement in feces of patients with colorectal cancer. Dis Colon Rectum 30:607–610CrossRefPubMed Shimano T, Okuda H, Monden T, Inaji H, Mori T (1987) Usefulness of carcinoembryonic antigen measurement in feces of patients with colorectal cancer. Dis Colon Rectum 30:607–610CrossRefPubMed
Metadata
Title
Crohn’s disease-associated colorectal cancer in Japan: report of four cases
Authors
Tadataka Hayashi
Toshio Nakamura
Kiyotaka Kurachi
Atsuko Fukazawa
Akihito Nakajima
Koichi Nakamura
Shohachi Suzuki
Hiroyuki Konno
Publication date
01-12-2007
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 12/2007
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-007-0371-2

Other articles of this Issue 12/2007

International Journal of Colorectal Disease 12/2007 Go to the issue