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Published in: International Journal of Colorectal Disease 6/2006

01-09-2006 | Invited Commentary

Critical comment: analyzing the effect of novel therapies on cytokine expression in inflammatory bowel disease: do cytokine levels reflect clinical response?

Authors: B. M. Wittig, M. Zeitz

Published in: International Journal of Colorectal Disease | Issue 6/2006

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Abstract

Over the past several years, research in the field of cytokine production and function has become indispensable to understand the immunopathology of chronic intestinal inflammation. Thereupon, clinical studies analyzing cytokine production have generated a tremendous amount of data. In patients with inflammatory bowel disease, several studies examined pro-inflammatory cytokines in gut tissue and plasma, but a clear interpretation of the results with respect to disease activity or therapeutic response has been hampered by patient- and sample-related pitfalls.
Literature
1.
go back to reference Fiocchi C (1998) Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115:182–205PubMedCrossRef Fiocchi C (1998) Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115:182–205PubMedCrossRef
2.
go back to reference Gotteland M, Lopez M, Munoz C, Saez R, Altshiller H, Llorens P, Brunser O (1999) Local and systemic liberation of proinflammatory cytokines in ulcerative colitis. Dig Dis Sci 44:830–835PubMedCrossRef Gotteland M, Lopez M, Munoz C, Saez R, Altshiller H, Llorens P, Brunser O (1999) Local and systemic liberation of proinflammatory cytokines in ulcerative colitis. Dig Dis Sci 44:830–835PubMedCrossRef
3.
go back to reference Gross V, Andus T, Ceasar I, Roth M, Schoelmerich J (1992) Evidence for continuous stimulation of interleukin-6 production in Crohn’s disease. Gastroenterology 102:514–519PubMed Gross V, Andus T, Ceasar I, Roth M, Schoelmerich J (1992) Evidence for continuous stimulation of interleukin-6 production in Crohn’s disease. Gastroenterology 102:514–519PubMed
4.
go back to reference Kusugami K, Ina K, Ando T, Hibi K, Nishio Y, Goto H (2004) Immunomodulatory therapy for inflammatory bowel disease. J Gastroenterol 39:1129–1137PubMedCrossRef Kusugami K, Ina K, Ando T, Hibi K, Nishio Y, Goto H (2004) Immunomodulatory therapy for inflammatory bowel disease. J Gastroenterol 39:1129–1137PubMedCrossRef
5.
go back to reference Lieberman BY, Fiocchi C, Youngman KR, Sapatnekar WK, Proffit MR (1988) Interferon-g production by human intestinal mucosal mononuclear cells. Decreased levels in inflammatory bowel disease. Dig Dis Sci 33:1297–1304PubMedCrossRef Lieberman BY, Fiocchi C, Youngman KR, Sapatnekar WK, Proffit MR (1988) Interferon-g production by human intestinal mucosal mononuclear cells. Decreased levels in inflammatory bowel disease. Dig Dis Sci 33:1297–1304PubMedCrossRef
6.
go back to reference Lochs H, Adler G, Beglinger C, Duchmann R, Emmrich J, Ewe K, Gangl A, Gasche C, Hahn E, Hoffmann P, Kaskas B, Malchow H, Pohl C, Raedler A, Renner E, Schölmerich J, Schreiber S, Stange E, Tilg H, Vogelsang H, Weigert N, Zeitz M (1999) Anti-TNF antibody in Crohn’s disease—status of information, comments and recommendations of an international working group. Z Gastroenterol 37:509–512PubMed Lochs H, Adler G, Beglinger C, Duchmann R, Emmrich J, Ewe K, Gangl A, Gasche C, Hahn E, Hoffmann P, Kaskas B, Malchow H, Pohl C, Raedler A, Renner E, Schölmerich J, Schreiber S, Stange E, Tilg H, Vogelsang H, Weigert N, Zeitz M (1999) Anti-TNF antibody in Crohn’s disease—status of information, comments and recommendations of an international working group. Z Gastroenterol 37:509–512PubMed
7.
go back to reference Mahida YR, Kurlac L, Gallagher A, Hawkey CJ (1991) High circulating concentrations of interleukin-6 in active Crohn’s disease but not ulcerative colitis. Gut 32:1531–1534PubMedCrossRef Mahida YR, Kurlac L, Gallagher A, Hawkey CJ (1991) High circulating concentrations of interleukin-6 in active Crohn’s disease but not ulcerative colitis. Gut 32:1531–1534PubMedCrossRef
8.
go back to reference Matsuura T, West GA, Kleins JS, Ferraris L, Fiocchi L (1992) Soluble interleukin-2 and CD8 and CD4 receptors in inflammatory bowel disease. Gastroenterology 102:2006–2014PubMed Matsuura T, West GA, Kleins JS, Ferraris L, Fiocchi L (1992) Soluble interleukin-2 and CD8 and CD4 receptors in inflammatory bowel disease. Gastroenterology 102:2006–2014PubMed
9.
go back to reference Mitsuyama K, Suzuki A, Matsumoto S, Tomiyasu N, Takaki K, Takedatsu H, Masuda J, Handa K, Harada K, Nishida H, Toyonaga A, Sata M (2005) Diminished cytokine signalling against bacterial components in mononuclear leucocytes from ulcerative colitis patients after leukocytapheresis. Clin Exp Immunol 141:130–140PubMedCrossRef Mitsuyama K, Suzuki A, Matsumoto S, Tomiyasu N, Takaki K, Takedatsu H, Masuda J, Handa K, Harada K, Nishida H, Toyonaga A, Sata M (2005) Diminished cytokine signalling against bacterial components in mononuclear leucocytes from ulcerative colitis patients after leukocytapheresis. Clin Exp Immunol 141:130–140PubMedCrossRef
10.
go back to reference Muratov V, Lundahl J, Ulfgren A, Elvin K, Fehrman I, Ahlborg N, Ost A, Hittel N, Saniabadi A, Lofberg R (2005) Downregulation of interferon-g parallels clinical response to selective leukocyte apheresis in patients with inflammatory bowel disease. A 12-month follow-up study. Int J Colorectal Dis (in press) http://dx.doi.org/10.1007/s00384-005-0069-2 Muratov V, Lundahl J, Ulfgren A, Elvin K, Fehrman I, Ahlborg N, Ost A, Hittel N, Saniabadi A, Lofberg R (2005) Downregulation of interferon-g parallels clinical response to selective leukocyte apheresis in patients with inflammatory bowel disease. A 12-month follow-up study. Int J Colorectal Dis (in press) http://​dx.​doi.​org/​10.​1007/​s00384-005-0069-2
11.
go back to reference Niederau C, Backmerhoff F, Schumacher B, Christoph N (1997) Inflammatory mediators and acute phase proteins in patients with Crohn’s disease and ulcerative colitis. Hepatogastroenterology 44:90–107PubMed Niederau C, Backmerhoff F, Schumacher B, Christoph N (1997) Inflammatory mediators and acute phase proteins in patients with Crohn’s disease and ulcerative colitis. Hepatogastroenterology 44:90–107PubMed
12.
go back to reference Ogura Y, Imamura Y, Murakami Y, Takesue Y, Yokoyama T, Sueda T, Hiyama E (2005) Intracellular cytokine patterns of peripheral blood T cells as a useful indicator of activeness of Crohn’ disease. Hiroshima J Med Sci 54:1–8PubMed Ogura Y, Imamura Y, Murakami Y, Takesue Y, Yokoyama T, Sueda T, Hiyama E (2005) Intracellular cytokine patterns of peripheral blood T cells as a useful indicator of activeness of Crohn’ disease. Hiroshima J Med Sci 54:1–8PubMed
13.
go back to reference Raddatz D, Bockemuhl M, Ramadori G (2005) Quantitative measurement of cytokine mRNA in inflammatory bowel disease: relation to clinical and endoscopic activity and outcome. Eur J Gastroenterol Hepatol 17:547–557PubMedCrossRef Raddatz D, Bockemuhl M, Ramadori G (2005) Quantitative measurement of cytokine mRNA in inflammatory bowel disease: relation to clinical and endoscopic activity and outcome. Eur J Gastroenterol Hepatol 17:547–557PubMedCrossRef
14.
go back to reference Rogler G (2004) Update in inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol 20:311–317PubMedCrossRef Rogler G (2004) Update in inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol 20:311–317PubMedCrossRef
15.
go back to reference Sartor RB (1994) Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 106:533–539PubMed Sartor RB (1994) Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 106:533–539PubMed
16.
go back to reference Sawada K, Muto T, Shimoyama T, Satomi M, Sawada T, Nagawa H, Hiwatashi N, Asakura H, Hibi T (2003) Multicenter randomized controlled trial for the treatment of ulcerative colitis with a leukocytapheresis column. Curr Pharm Des 9:307–321PubMedCrossRef Sawada K, Muto T, Shimoyama T, Satomi M, Sawada T, Nagawa H, Hiwatashi N, Asakura H, Hibi T (2003) Multicenter randomized controlled trial for the treatment of ulcerative colitis with a leukocytapheresis column. Curr Pharm Des 9:307–321PubMedCrossRef
17.
go back to reference Shinoda T (2002) Photopheresis and leukocytapheresis: cytapheresis treatment against immune-mediated diseases. Ther Apher 6:245–246PubMedCrossRef Shinoda T (2002) Photopheresis and leukocytapheresis: cytapheresis treatment against immune-mediated diseases. Ther Apher 6:245–246PubMedCrossRef
Metadata
Title
Critical comment: analyzing the effect of novel therapies on cytokine expression in inflammatory bowel disease: do cytokine levels reflect clinical response?
Authors
B. M. Wittig
M. Zeitz
Publication date
01-09-2006
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 6/2006
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-005-0082-5

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