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Open Access 01-12-2024 | Craniopharyngioma | Research

Gut microbiota composition and metabolic characteristics in patients with Craniopharyngioma

Authors: Chunhui Liu, Fangzheng Liu, Ding Nie, Youchao Xiao, Wentao Wu, Yanfei Jia, Lu Jin, Ning Qiao, Kefan Cai, Siming Ru, Xin Liu, Yifan Song, Jintian Xu, Lei Cao, Songbai Gui

Published in: BMC Cancer | Issue 1/2024

Abstract

Background

Emerging evidence suggests that the gut microbiota is associated with various intracranial neoplastic diseases. It has been observed that alterations in the gut microbiota are present in gliomas, meningiomas, and pituitary neuroendocrine tumors (Pit-NETs). However, the correlation between gut microbiota and craniopharyngioma (CP), a rare embryonic malformation tumor in the sellar region, has not been previously mentioned. Consequently, this study aimed to investigate the gut microbiota composition and metabolic patterns in CP patients, with the goal of identifying potential therapeutic approaches.

Methods

We enrolled 15 medication-free and non-operated patients with CP and 15 healthy controls (HCs), conducting sequential metagenomic and metabolomic analyses on fecal samples to investigate changes in the gut microbiota of CP patients.

Results

The composition of gut microbiota in patients with CP compared to HCs show significant discrepancies at both the genus and species levels. The CP group exhibits greater species diversity. And the metabolic patterns between the two groups vary markedly.

Conclusions

The gut microbiota composition and metabolic patterns in patients with CP differ significantly from the healthy population, presenting potential new therapeutic opportunities.

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Title: Gut microbiota composition and metabolic characteristics in patients with Craniopharyngioma
Authors: Chunhui Liu
Fangzheng Liu
Ding Nie
Youchao Xiao
Wentao Wu
Yanfei Jia
Lu Jin
Ning Qiao
Kefan Cai
Siming Ru
Xin Liu
Yifan Song
Jintian Xu
Lei Cao
Songbai Gui
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Craniopharyngioma
Respiratory Microbiota
Published in: BMC Cancer / Issue 1/2024
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-024-12283-w

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Abstract

Background

Methods

Results

Conclusions

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