Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Head and Neck Pathology
Published in: Head and Neck Pathology 4/2022

03-08-2022 | Craniopharyngioma | Review

Clinical, Radiographic and Histopathological Analysis of Craniopharyngiomas and Ameloblastomas: A Systematic Review

Authors: Luana Amorim Morais da Silva, Solimar Ribeiro Carlete Filho, Marcelo Jales Diniz Saraiva, Caio Rodrigues Maia, Camila Dannyelle Fernandes Dutra Pereira Santos, Pedro Paulo de Andrade Santos

Published in: Head and Neck Pathology | Issue 4/2022

Login to get access

Abstract

Background

Craniopharyngiomas and ameloblastomas are tumors of epithelial origin, mostly characterized by a benign course, slow growth and for being locally invasive. Some studies highlight the similarity of these neoplasms, especially regarding histopathological aspects. In this context, the aim of the present study was to carry out a systematic literature review correlating the clinical, radiographic, and histopathological aspects of these two tumors.

Methods

Searches were conducted at the Pubmed, Periódicos Capes, Scopus, Science Direct, Web of Science and Scielo databases, according to the following inclusion criteria: publications in English or Spanish, from the 2000s and 2021, comprising case report studies, case series and literature reviews.

Results

Considering clinical and radiographic aspects, it is evident that craniopharyngiomas and ameloblastomas exhibit few similarities. Histopathologically, however, adamantinomatous craniopharyngiomas are the type of tumor that most resembles ameloblastomas, both concerning the formation of palisade epithelial cords and epithelial formations. Regarding to recurrences in cases of craniopharyngioma, it appears that a more radical surgical resection is more related to a lower recurrence rate for both craniopharyngiomas and ameloblastomas. As for the outcome, it was observed that craniopharyngiomas have a greater relationship with possible systemic disorders.

Conclusions

This histopathological similarity is related to their origin, since both craniopharyngiomas and ameloblastomas share a relationship with the oral cavity, either partially, as in the case of craniopharyngiomas, or totally, as in ameloblastomas, not comprising the same lesion in different locations. It is important to note that the differential morphogenetic evidence observed herein between these lesions opens up a new field of study aiming at better treatment alternatives in the future.
Literature
1.
Müller H, Merchant T, Warmuth-Metz M, Martinez-Barbera JP, Puget S. Craniopharyngioma. Nat Rev Dis Primers. 2019; 5(1).
2.
Kiliç M, Can S, Özdemir B, Tanik C. Management of Craniopharyngioma. J Craniofac Surg. 2019;30(2):e178–83.CrossRef
3.
Badger K, Gardner D. The relationship of adamantinomatous craniopharyngioma to ghost cell ameloblastoma of the jaws: a histopathologic and immunohistochemical study. J Oral Pathol Med. 1997;26(8):349–55.CrossRef
4.
Masthan K, Anitha K, Krupaa J, Manikkam S. Ameloblastoma. J Pharm Bioallied Sci. 2015;7(1):167-70.
5.
Adeel M, Rajput M, Arain A. Ameloblastoma: Management and Outcome. Cureus. 2018;10(10):e3437.
6.
Evangelou Z, Zarachi A, Dumollard J. Maxillary Ameloblastoma: A Review With Clinical, Histological and Prognostic Data of a Rare Tumor. Vivo. 2020;34(5):2249–58.CrossRef
7.
Falavigna A, Kraemer J. Infrasellar craniopharyngioma: case report. Arq Neuropsiquiatr. 2001;59(2B):424–30.CrossRef
8.
Deutsch H, Kothbauer K, Persky M, Epstein F, Jallo G. Infrasellar Craniopharyngiomas: Case Report and Review of the Literature. Skull Base. 2001;11(2):121–8.CrossRef
9.
Yamini B, Narayanan M. Craniopharyngiomas: an update. Expert Rev Anticancer Ther. 2006;6(1):85–92.CrossRef
10.
Krishnapillai R, Angadi P. A clinical, radiographic, and histologic review of 73 cases of ameloblastoma in an Indian population. Quintessence Int. 2010;41(5):e90–100.
11.
Fregnani ER, da Cruz Perez DE, de Almeida OP, et al. Clinicopathological study and treatment outcomes of 121 cases of ameloblastomas. Int J Oral Maxillofac Surg. 2010;39:145–9.CrossRef
12.
Magill J, Ferguson M, Sandison A, Clarke P. Nasal craniopharyngioma: case report and literature review. J Laryngol Otol. 2011;125(05):517–9.CrossRef
13.
Gao S, Shi X, Wang Y, Qian H, Liu C. Malignant transformation of craniopharyngioma: case report and review of the literature. J Neurooncol. 2011;103(3):719–25.CrossRef
14.
Lee S, Kim Y. Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor. Korean J Pathol. 2013;47(3):191–202.CrossRef
15.
Nair P, Bhat G, Neelakantan S. Desmoplastic ameloblastoma of mandible. BMJ Case Rep. 2013; 2013: bcr2013200082.
16.
Gloria J. Extragnathic Sinonasal Ameloblastoma: A Rare Benign Intranasal Tumor with Malignant Features. Philipp J Otolaryngol Head Neck Surg. 2013;28(1):19–23.CrossRef
17.
Bansal S, Desai R, Shirsat P. The occurrence and pattern of ameloblastoma in children and adolescents: an Indian institutional study of 41 years and review of the literature. Int J Oral Maxillofac Surg. 2015;44(6):725–31.CrossRef
18.
Milman T, Ying GS, Pan W, LiVolsi V. Ameloblastoma: 25 Year Experience at a Single Institution. Head Neck Pathol. 2016;10:513–20.CrossRef
19.
Okada T, Fujitsu K, Ichikawa T, et al. Unicystic Ameloblastoma Cystic Craniopharyngioma: Pathological Discussion and Clinical Significance of Cyst Formation in Adamantinomatous Craniopharyngioma. Pediatr Neurosurg. 2016;51(3):158–63.CrossRef
20.
Adeel M, Rajput MSA, Arain AA, Baloch M, Khan M. Ameloblastoma: Management and Outcome. Cureus. 2018;10(10):e3437.
21.
Omay SB, Chen YN, Almeida JP, et al. Do craniopharyngioma molecular signatures correlate with clinical characteristics? J Neurosurg. 2018;128:1473–8.CrossRef
22.
Drapeau A, Walzm C, Eide J, et al. Pediatric craniopharyngioma. Child Nerv Syst. 2019;35(11):2133–45.CrossRef
23.
Mende KC, Kellner T, Petersenn S, et al. Clinical Situation, Therapy, and Follow-Up of Adult Craniopharyngioma Report from the German Craniopharyngioma Registry. J Clin Endocrinol Metab. 2020;105(1):252–65.CrossRef
24.
Sharma A, Ingole S, Deshpande M. Retrospective analysis of Desmoplastic Ameloblastoma: Clinical review. Med Oral Patol Oral Cir Bucal. 2021;26(2):e246–55.CrossRef
25.
Fugio S, Juratli TA, Takajo T, et al. Craniopharyngiomas, including Recurrent Cases, Lack TERT Promoter Hotspot Mutations. Neurol Med Chir (Tokyo). 2021;61:385–91.CrossRef
26.
Hresko A, Burtyn O, Pavlovskiy L, et al. Controversies in ameloblastoma management: evaluation of decision making, based on a retrospective analysis. Med Oral Patol Oral Cir Bucal. 2021;26(2):e181–6.CrossRef
27.
Kopparapu S, Khalafallah AM, Botros D, et al. Predictors of Postoperative Visual Outcome After Surgical Intervention for Craniopharyngiomas. World Neurosurg. 2021;148:e589–99.CrossRef
28.
29.
Garnett M, Puget S, Grill J, Sainte-Rose C, Craniopharyngioma. Orphanet J Rare Dis. 2007;2(1):18.CrossRef
30.
Larkin S, Ansorge O. Pathology and pathogenesis of craniopharyngiomas. Pituitary. 2013;16:9–17.CrossRef
31.
Burger P, Scheithayer B. Tumors of the central nervous system. Atlas of Tumor Pathology, 1994, p 349–69. Armed Forces Institute of Pathology, Washington, DC.
32.
Petito C, DeGirolami U, Earle K. Craniopharyngiomas. A clinical and pathological review. Cancer. 1976;37:1944–52.CrossRef
33.
WHO Classification of Head and Neck Tumours. In. El-Naggar A, Chan JKC, Grandis JR et al, editors Lyon, France: IARC Press; 2017.
34.
Apps JR, Carreno G, Gonzalez-Meljem JM, et al. Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target. Acta Neuropathol. 2018;135:757–77.CrossRef
35.
Kato K, Nakatani Y, Kanno H, et al. Possible linkage between specific histological structures and aberrant reactivation of the Wnt pathway in adamantinomatous craniopharyngioma. J Pathol. 2004;203:814–82.CrossRef
36.
Tateyama H, Tada T, Okabe M, Takahashi E, Eimoto T. Different keratin profiles in craniopharyngioma subtypes and ameloblastomas. Pathol Res Pract. 2001;197(11):735–42.CrossRef
37.
Adamson TE, Wistler OD, Kleihues P, Yasargil MG. Correlation of clinical and pathological features in surgically treated craniopharyngiomas. J Neurosurg. 1990;73:12–7.CrossRef
38.
Crotty T, Scheithauer B, Young JR, et al. Pappilary craniopharyngioma: a clinicopathological study of 48 cases. J Neurosurg. 1995;83:206–14.CrossRef
39.
Hetelekids S, Barnes P, Tao M, et al. 20-year experience in childhood craniopharyngiomas. Int J Radiat Oncol Biol Phys. 1993;27:189–95.CrossRef
40.
Dias CD, Brandão TB, Soares FA, Lourenço SV. Ameloblastomas: clinical-histopathological evaluation of 85 cases with emphasis on squamous metaplasia and keratinization aspects. Acta Odontol Scand. 2013;71(6):1651–5.CrossRef
41.
Gomes CC, Sousa SF, Gomez RS. Craniopharyngiomas and odontogenic tumors mimic normal odontogenesis and share genetic mutations, histopathologic features, and molecular pathways activation. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;127:231–6.CrossRef
Metadata
Title
Clinical, Radiographic and Histopathological Analysis of Craniopharyngiomas and Ameloblastomas: A Systematic Review
Authors
Luana Amorim Morais da Silva
Solimar Ribeiro Carlete Filho
Marcelo Jales Diniz Saraiva
Caio Rodrigues Maia
Camila Dannyelle Fernandes Dutra Pereira Santos
Pedro Paulo de Andrade Santos
Publication date
03-08-2022
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 4/2022
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-022-01473-2

Other articles of this Issue 4/2022

Head and Neck Pathology 4/2022 Go to the issue

Original Paper

Infiltration of Mature KLRG1 Expressing Cytotoxic T Cells in Oral Lichen Planus

Original Paper

Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study

Original Paper

Evaluation of Expression Of ADAM 10 as a Predictor of Lymph Node Metastasis in Oral Squamous Cell Carcinoma—An Immunohistochemical Study

Original Paper

Proposal of Diagnostic Approach of Periodontal Primary Non Hodgkin Lymphoma of Bone with Flow Cytometry as an Essential Diagnostic Component

Review

Prognostic Relevance of Lymphatic Vessel Density in Squamous Cell Carcinomas of the Oral Cavity: A Systematic Review and Meta-Analysis

Sine qua non Radiology-Pathology

Sine Qua Non: Oncocytoma