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Quality of Life Research
Published in: Quality of Life Research 12/2020

01-12-2020 | Craniomandibular Dysfunction and Stress

Depression, temporomandibular disorders, and genetic polymorphisms in IL6 impact on oral health-related quality of life in patients requiring orthognathic surgery

Authors: Aline Monise Sebastiani, Katheleen Miranda dos Santos, Rafael Correia Cavalcante, Maria Fernanda Pivetta Petinati, Luciana Signorini, Livia Azeredo Alves Antunes, Nelson Luis Barbosa Rebellato, Erika Calvano Küchler, Rafaela Scariot

Published in: Quality of Life Research | Issue 12/2020

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Abstract

Purpose

To assess oral health-related quality of life (OHRQoL) in patients requiring orthognathic surgery, and evaluate if depression, temporomandibular disorders (TMD), and genetic polymorphisms in interleukin-6 (IL6) influence their OHRQoL.

Methods

A total of 132 individuals included in three different groups. Two groups were composed by patients with dentofacial deformity (DFD) Class II (n = 44) or Class III (n = 44) malocclusions, requiring orthognathic surgery. The control group (n = 44) included individuals without DFD. Patients from all groups were evaluated in preoperative appointments to assessOHRQoL, TMD, and genetic polymorphisms in IL6. OHRQoL was assessed using the 14-item Oral Health Impact Profile (OHIP-14). TMD and depression were assessed using Research Diagnostic Criteria for Temporomandibular Disorders protocol. The genetic polymorphisms rs1800795 and rs1800796 in IL6 were assessed through genomic DNA using real-time polymerase chain reaction.

Results

OHIP-14 scores were increased in patients with depression, myofascial pain, and inflammatory temporomandibular joint alterations in the right side, regardless of sex and DFD group. Individual homozygous CC in rs1800795 had increased values in domains “social disability” and “handicap” of the OHIP-14 compared with those who were homozygous GG. Individual heterozygous CG in the rs1800796 demonstrated increased values in domain “psychological discomfort” compared with those homozygous for CC and GG.

Conclusion

In individuals requiring orthognathic surgery, depression, TMD, and genetic polymorphisms in IL6 contribute to negative impact on OHRQoL. These physical and emotional conditions, together with biological pathways, should receive more attention in treatment plans, in order to improve the patients’ quality of life.
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Metadata
Title
Depression, temporomandibular disorders, and genetic polymorphisms in IL6 impact on oral health-related quality of life in patients requiring orthognathic surgery
Authors
Aline Monise Sebastiani
Katheleen Miranda dos Santos
Rafael Correia Cavalcante
Maria Fernanda Pivetta Petinati
Luciana Signorini
Livia Azeredo Alves Antunes
Nelson Luis Barbosa Rebellato
Erika Calvano Küchler
Rafaela Scariot
Publication date
01-12-2020
Publisher
Springer International Publishing
Published in
Quality of Life Research / Issue 12/2020
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-020-02581-8

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