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BMC Oral Health
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | COVID-19 | Research

The underlying molecular mechanisms and biomarkers between periodontitis and COVID-19

Authors: Danlei Qin, Feiyan Yu, Dongchao Wu, Chong Han, Xuemin Yao, Lulu Yang, Xi Yang, Qianqian Wang, Dongning He, Bin Zhao

Published in: BMC Oral Health | Issue 1/2023

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Abstract

Objective

Emerging evidence shows the clinical consequences of patient with COVID-19 and periodontitis are not promising, and periodontitis is a risk factor. Periodontitis and COVID-19 probably have a relationship. Hence, this study aimed to identify the common molecular mechanism that may help to devise potential therapeutic strategies in the future.

Material and methods

We analyzed two RNA-seq datasets for differential expressed genes, enrichment of biological processes, transcription factors (TFs) and deconvolution-based immune cell types in periodontitis, COVID-19 and healthy controls. Relationships between TFs and mRNA were established by Pearson correlation analysis, and the common TFs-mRNA regulatory network and nine co-upregulated TFs of the two diseases was obtained. The RT-PCR detected the TFs.

Results

A total of 1616 and 10201 differentially expressed gene (DEGs) from periodontitis and COVID-19 are found. Moreover, nine shared TFs and common biological processes associated with lymphocyte activation involved in immune response were identified across periodontitis and COVID-19. The cell type enrichment revealed elevated plasma cells among two diseases. The RT-PCR further confirmed the nine TFs up-regulation in periodontitis.

Conclusion

The pathogenesis of periodontitis and COVID-19 is closely related to the expression of TFs and lymphocyte activation, which can provide potential targets for treatment.
Appendix
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Metadata
Title
The underlying molecular mechanisms and biomarkers between periodontitis and COVID-19
Authors
Danlei Qin
Feiyan Yu
Dongchao Wu
Chong Han
Xuemin Yao
Lulu Yang
Xi Yang
Qianqian Wang
Dongning He
Bin Zhao
Publication date
01-12-2023
Publisher
BioMed Central
Keyword
COVID-19
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-03150-4

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