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01-12-2021 | COVID-19 | Research Letter

Role of endothelial miR-24 in COVID-19 cerebrovascular events

Authors: Jessica Gambardella, Antonietta Coppola, Raffaele Izzo, Giuseppe Fiorentino, Bruno Trimarco, Gaetano Santulli

Published in: Critical Care | Issue 1/2021

Excerpt

Levels of microRNAs (miRNAs) within extracellular vesicles (EVs) have been shown to be useful diagnostic and prognostic biomarkers in a number of disease states [1‐3]. However, EVs miRNAs have never been investigated in COVID-19. …

Prattichizzo F, De Nigris V, Sabbatinelli J, Giuliani A, Castano C, Parrizas M, Crespo I, Grimaldi A, Baranzini N, Spiga R, et al. CD31(+) extracellular vesicles from patients with type 2 diabetes shuttle a miRNA signature associated with cardiovascular complications. Diabetes. 2021;70(1):240–54.CrossRef

Mori MA, Ludwig RG, Garcia-Martin R, Brandao BB, Kahn CR. Extracellular miRNAs: from biomarkers to mediators of physiology and disease. Cell Metab. 2019;30(4):656–73.CrossRef

Santulli G. microRNA: Medical Evidence - From Molecular Biology to Clinical Practice. Hardcover Book (Springer International Publishing, Switzerland), 2015; ISBN: 978-3-319-22670-5. https://doi.org/10.1007/978-3-319-22671-2 .

Mone P, Gambardella J, Wang X, Jankauskas SS, Matarese A, Santulli G. miR-24 Targets the Transmembrane Glycoprotein Neuropilin-1 in Human Brain Microvascular Endothelial Cells. Noncoding RNA. 2021;7(1):9.PubMedPubMedCentral

Mayi BS, Leibowitz JA, Woods AT, Ammon KA, Liu AE, Raja A. The role of Neuropilin-1 in COVID-19. PLoS Pathog. 2021;17(1):e1009153.CrossRef

Santulli G, Wronska A, Uryu K, Diacovo TG, Gao M, Marx SO, Kitajewski J, Chilton JM, Akat KM, Tuschl T, et al. A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest. 2014;124(9):4102–14.CrossRef

Title: Role of endothelial miR-24 in COVID-19 cerebrovascular events
Authors: Jessica Gambardella
Antonietta Coppola
Raffaele Izzo
Giuseppe Fiorentino
Bruno Trimarco
Gaetano Santulli
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: COVID-19
Published in: Critical Care / Issue 1/2021
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-021-03731-1

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Role of endothelial miR-24 in COVID-19 cerebrovascular events

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