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Published in: BMC Geriatrics 1/2024

Open Access 01-12-2024 | COVID-19 | Research

A pulmonary rehabilitation program is an effective strategy to improve forced vital capacity, muscle strength, and functional exercise capacity similarly in adults and older people with post-severe COVID-19 who required mechanical ventilation

Authors: Rodrigo Muñoz-Cofré, María Fernanda del Valle, Gabriel Nasri Marzuca-Nassr, Jorge Valenzuela, Mariano del Sol, Constanza Díaz Canales, Pablo A. Lizana, Fernando Valenzuela-Aedo, Rodrigo Lizama-Pérez, Máximo Escobar-Cabello

Published in: BMC Geriatrics | Issue 1/2024

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Abstract

Background

It is internationally known that our population is aging. At the same time, some patients with COVID-19, due to their symptoms, required mechanical ventilation (MV) and subsequent pulmonary rehabilitation (PR). This study aimed to compare the effects of a multimodal PR program “ADULT” versus “OLDER” people with COVID-19 who were on MV.

Methods

The intervention consisted of an 8-week hybrid PR program (2x week). Forced vital capacity (FVC) was measured at the beginning and end of PR, upper and lower limb strength was obtained through hand grip strength (HGS) and the sit-to-stand test (STST), respectively, and functional exercise capacity was measured with the 6-minute walking test (6MWT).

Results

The main results were an increase in the FVC in the ADULT and OLDER groups (time effect, P = 0.000; η2 = 0.27), an increase in HGS in the ADULT and OLDER groups (time effect, P = 0.000; η2 = 0.52), in the same way, the number of repetitions on the STST increased in the ADULT and OLDER groups (time effect, P = 0.000; η2 = 0.55). Finally, the distance covered on the 6MWT increased in the ADULT and OLDER groups (time effect, P = 0.000; η2 = 0.65).

Conclusions

The PR program is an effective strategy to improve FVC, muscle strength, and functional exercise capacity similarly in adults and older people with post severe COVID-19 who required MV.
Literature
1.
go back to reference Tiryaki Ş, Dabeşlim H, Aksu Y. Chest computed tomographic findings of patients with COVID-19-related pneumonia. Acta Radiol Open. 2021;10(2):2058460121989309.PubMedPubMedCentral Tiryaki Ş, Dabeşlim H, Aksu Y. Chest computed tomographic findings of patients with COVID-19-related pneumonia. Acta Radiol Open. 2021;10(2):2058460121989309.PubMedPubMedCentral
2.
go back to reference Aksu Y, Uslu AU, Tarhan G, Karagülle M, Tiryaki Ş. The relationship among Splenomegaly, Lung involvement patterns, and severity score in COVID-19 Pneumonia. Curr Med Imaging. 2022;18(12):1311–7.CrossRefPubMed Aksu Y, Uslu AU, Tarhan G, Karagülle M, Tiryaki Ş. The relationship among Splenomegaly, Lung involvement patterns, and severity score in COVID-19 Pneumonia. Curr Med Imaging. 2022;18(12):1311–7.CrossRefPubMed
3.
go back to reference Del Valle MF, Valenzuela J, Godoy L, Del Sol M, Lizana PA, Escobar-Cabello M, Muñoz-Cofre R. Letter Chile Respirol. 2022;27(2):173–74. Del Valle MF, Valenzuela J, Godoy L, Del Sol M, Lizana PA, Escobar-Cabello M, Muñoz-Cofre R. Letter Chile Respirol. 2022;27(2):173–74.
4.
go back to reference Horton R, Offline. COVID-19 is not a pandemic. Lancet. 2020;396(10228):935.CrossRef Horton R, Offline. COVID-19 is not a pandemic. Lancet. 2020;396(10228):935.CrossRef
5.
go back to reference Wang TJ, Chau B, Lui M, Lam GT, Lin N, Humbert S. Physical Medicine and Rehabilitation and Pulmonary Rehabilitation for COVID-19. Am J Phys Med Rehabil. 2020;99(9):769–74.CrossRefPubMed Wang TJ, Chau B, Lui M, Lam GT, Lin N, Humbert S. Physical Medicine and Rehabilitation and Pulmonary Rehabilitation for COVID-19. Am J Phys Med Rehabil. 2020;99(9):769–74.CrossRefPubMed
6.
go back to reference Alvarez R, Del Valle MF, Cordero P, del Sol M, Lizana PA, Gutierrez J, Valenzuela J, Munoz-Cofré R. Shoulder Pain in COVID-19 survivors following mechanical ventilation. Int J Environ Res Public Health. 2021;18(19):10434.CrossRefPubMedPubMedCentral Alvarez R, Del Valle MF, Cordero P, del Sol M, Lizana PA, Gutierrez J, Valenzuela J, Munoz-Cofré R. Shoulder Pain in COVID-19 survivors following mechanical ventilation. Int J Environ Res Public Health. 2021;18(19):10434.CrossRefPubMedPubMedCentral
7.
go back to reference Spruit MA, Holland AE, Singh SJ, Tonia T, Wilson KC, Troosters T. COVID-19: Interim Guidance on Rehabilitation in the Hospital and Post-hospital Phase from a European Respiratory Society and American Thoracic Society-Coordinated International Task Force. Eur Respir J. 2020;56(6):2002197.CrossRefPubMedPubMedCentral Spruit MA, Holland AE, Singh SJ, Tonia T, Wilson KC, Troosters T. COVID-19: Interim Guidance on Rehabilitation in the Hospital and Post-hospital Phase from a European Respiratory Society and American Thoracic Society-Coordinated International Task Force. Eur Respir J. 2020;56(6):2002197.CrossRefPubMedPubMedCentral
8.
go back to reference Daher A, Balfanz P, Cornelissen C, Müller A, Bergs I, Marx N, Müller-Wieland D, Hartmann B, Dreher M, Müller T. Follow up of patients with severe coronavirus disease 2019 (COVID-19): Pulmonary and extrapulmonary disease sequelae. Respir Med. 2020;174:106197.CrossRefPubMedPubMedCentral Daher A, Balfanz P, Cornelissen C, Müller A, Bergs I, Marx N, Müller-Wieland D, Hartmann B, Dreher M, Müller T. Follow up of patients with severe coronavirus disease 2019 (COVID-19): Pulmonary and extrapulmonary disease sequelae. Respir Med. 2020;174:106197.CrossRefPubMedPubMedCentral
9.
go back to reference Khan MA, Hashim MJ, Mustafa H, Baniyas MY, Al Suwaidi S, Alkatheeri R, Alblooshi FMK, Almatrooshi MEAH, Alzaabi MEH, Al Darmaki RS, et al. Global epidemiology of ischemic heart disease: results from the global burden of disease study. Cureus. 2020;12(7):e9349.PubMedPubMedCentral Khan MA, Hashim MJ, Mustafa H, Baniyas MY, Al Suwaidi S, Alkatheeri R, Alblooshi FMK, Almatrooshi MEAH, Alzaabi MEH, Al Darmaki RS, et al. Global epidemiology of ischemic heart disease: results from the global burden of disease study. Cureus. 2020;12(7):e9349.PubMedPubMedCentral
10.
go back to reference Aguiar GB, Dourado KF, Andrade MIS, Domingos Júnior IR, Barros-Neto JA, Vasconcelos SML, Petribú MMV, Santos CMD, Moura MWS, Aguiar CB, et al. Frequency and factors associated with Sarcopenia prediction in adult and elderly patients hospitalized for COVID-19. Exp Gerontol. 2022;168:111945.CrossRefPubMedPubMedCentral Aguiar GB, Dourado KF, Andrade MIS, Domingos Júnior IR, Barros-Neto JA, Vasconcelos SML, Petribú MMV, Santos CMD, Moura MWS, Aguiar CB, et al. Frequency and factors associated with Sarcopenia prediction in adult and elderly patients hospitalized for COVID-19. Exp Gerontol. 2022;168:111945.CrossRefPubMedPubMedCentral
11.
go back to reference Rudnicka E, Napierala P, Podfigurna A, Meczekalski B, Smolarczyk R, Grymowicz M. The world health organization (who) approach to healthy ageing. Maturitas. 2020;139:6–11.CrossRefPubMedPubMedCentral Rudnicka E, Napierala P, Podfigurna A, Meczekalski B, Smolarczyk R, Grymowicz M. The world health organization (who) approach to healthy ageing. Maturitas. 2020;139:6–11.CrossRefPubMedPubMedCentral
12.
go back to reference Liu K, Chen Y, Lin R, Han K. Clinical features of COVID-19 in elderly patients: a comparison with young and middle-aged patients. J Infect. 2020;80(6):e14–8.CrossRefPubMedPubMedCentral Liu K, Chen Y, Lin R, Han K. Clinical features of COVID-19 in elderly patients: a comparison with young and middle-aged patients. J Infect. 2020;80(6):e14–8.CrossRefPubMedPubMedCentral
13.
go back to reference Piotrowicz K, Gąsowski J, Michel JP, Veronese N. Post-COVID-19 acute sarcopenia: physiopathology and management. Aging Clin Exp Res. 2021;33(10):2887–98.CrossRefPubMedPubMedCentral Piotrowicz K, Gąsowski J, Michel JP, Veronese N. Post-COVID-19 acute sarcopenia: physiopathology and management. Aging Clin Exp Res. 2021;33(10):2887–98.CrossRefPubMedPubMedCentral
14.
go back to reference Del Valle MF, Valenzuela J, Marzuca-Nassr GN, Cabrera-Inostroza C, del Sol M, Lizana PA, Escobar-Cabello M, Muñoz-Cofré R. Eight weeks of supervised Pulmonary Rehabilitation are effective in improving resting heart rate and heart rate recovery in severe COVID-19 patient survivors of mechanical ventilation. Med (Kaunas). 2022;58(4):514. Del Valle MF, Valenzuela J, Marzuca-Nassr GN, Cabrera-Inostroza C, del Sol M, Lizana PA, Escobar-Cabello M, Muñoz-Cofré R. Eight weeks of supervised Pulmonary Rehabilitation are effective in improving resting heart rate and heart rate recovery in severe COVID-19 patient survivors of mechanical ventilation. Med (Kaunas). 2022;58(4):514.
15.
go back to reference Del Valle MF, Valenzuela J, Marzuca-Nassr GN, Godoy L, Del Sol M, Lizana PA, Escobar-Cabello M, Muñoz-Cofré R. Use of the speed achieved on the 6MWT for programming aerobic training in patients recovering from severe COVID-19: an observational study. Ann Med. 2023;55(1):889–97.CrossRefPubMedPubMedCentral Del Valle MF, Valenzuela J, Marzuca-Nassr GN, Godoy L, Del Sol M, Lizana PA, Escobar-Cabello M, Muñoz-Cofré R. Use of the speed achieved on the 6MWT for programming aerobic training in patients recovering from severe COVID-19: an observational study. Ann Med. 2023;55(1):889–97.CrossRefPubMedPubMedCentral
16.
go back to reference Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ, Cooper BG, Hall GL, Hallstrand TS, Kaminsky DA, McCarthy K, McCormack MC, et al. Standardization of Spirometry 2019 Update. An official American Thoracic Society and European Respiratory Society Technical Statement. Am J Respir Crit Care Med. 2019;200(8):e70–88.CrossRefPubMedPubMedCentral Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ, Cooper BG, Hall GL, Hallstrand TS, Kaminsky DA, McCarthy K, McCormack MC, et al. Standardization of Spirometry 2019 Update. An official American Thoracic Society and European Respiratory Society Technical Statement. Am J Respir Crit Care Med. 2019;200(8):e70–88.CrossRefPubMedPubMedCentral
17.
go back to reference Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, Sayer AA. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing. 2011;40(4):423–29.CrossRefPubMed Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, Sayer AA. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing. 2011;40(4):423–29.CrossRefPubMed
18.
go back to reference Rikli RE, Jones CJ. Development and validation of criterion-referenced clinically relevant fitness standards for maintaining physical independence in later years. Gerontologist. 2013;53(2):255–67.CrossRefPubMed Rikli RE, Jones CJ. Development and validation of criterion-referenced clinically relevant fitness standards for maintaining physical independence in later years. Gerontologist. 2013;53(2):255–67.CrossRefPubMed
19.
go back to reference Muñoz-Cofré R, Medina-González P, Escobar-Cabello M. Análisis Del comportamiento temporal de variables fisiológicas y de esfuerzo en sujetos instruidos en la Prueba De Caminata en 6 minutos: Complemento A La Norma ATS. Fisioterapia. 2016;38(1):20–7.CrossRef Muñoz-Cofré R, Medina-González P, Escobar-Cabello M. Análisis Del comportamiento temporal de variables fisiológicas y de esfuerzo en sujetos instruidos en la Prueba De Caminata en 6 minutos: Complemento A La Norma ATS. Fisioterapia. 2016;38(1):20–7.CrossRef
20.
go back to reference Klok FA, Boon GJAM, Barco S, Endres M, Geelhoed JJM, Knauss S, Rezek SA, Spruit MA, Vehreschild J, Siegerink B. The Post-COVID-19 functional status scale: a tool to measure functional status over time after COVID-19. Eur Respir J. 2020;56(1):2001494.CrossRefPubMedPubMedCentral Klok FA, Boon GJAM, Barco S, Endres M, Geelhoed JJM, Knauss S, Rezek SA, Spruit MA, Vehreschild J, Siegerink B. The Post-COVID-19 functional status scale: a tool to measure functional status over time after COVID-19. Eur Respir J. 2020;56(1):2001494.CrossRefPubMedPubMedCentral
21.
go back to reference Hayden MC, Limbach M, Schuler M, Merkl S, Schwarzl G, Jakab K, Nowak D, Schultz K. Effectiveness of a three-week Inpatient Pulmonary Rehabilitation Program for patients after COVID-19: a prospective observational study. Int J Environ Res Public Health. 2021;18(17):9001.CrossRefPubMedPubMedCentral Hayden MC, Limbach M, Schuler M, Merkl S, Schwarzl G, Jakab K, Nowak D, Schultz K. Effectiveness of a three-week Inpatient Pulmonary Rehabilitation Program for patients after COVID-19: a prospective observational study. Int J Environ Res Public Health. 2021;18(17):9001.CrossRefPubMedPubMedCentral
22.
go back to reference Miyatake M, Okazaki T, Suzukamo Y, Matsuyama S, Tsuji I, Izumi S-I. High mortality in an older Japanese Population with low forced vital capacity and gender-dependent potential impact of muscle strength: longitudinal cohort study. J Clin Med. 2022;11(18):5264.CrossRefPubMedPubMedCentral Miyatake M, Okazaki T, Suzukamo Y, Matsuyama S, Tsuji I, Izumi S-I. High mortality in an older Japanese Population with low forced vital capacity and gender-dependent potential impact of muscle strength: longitudinal cohort study. J Clin Med. 2022;11(18):5264.CrossRefPubMedPubMedCentral
23.
go back to reference Liu K, Zhang W, Yang Y, Zhang J, Li Y, Chen Y. Respiratory rehabilitation in elderly patients with COVID-19: a randomized controlled study. Complement Ther Clin Pract. 2020;39:101166.CrossRefPubMedPubMedCentral Liu K, Zhang W, Yang Y, Zhang J, Li Y, Chen Y. Respiratory rehabilitation in elderly patients with COVID-19: a randomized controlled study. Complement Ther Clin Pract. 2020;39:101166.CrossRefPubMedPubMedCentral
24.
go back to reference Araújo BTS, Barros AEVR, Nunes DTX, Remígio de Aguiar MI, Mastroianni VW, de Souza JAF, Fernandes J, Campos SL, Brandão DC, Dornelas, de Andrade A. Effects of continuous aerobic training associated with resistance training on maximal and submaximal exercise tolerance, fatigue, and quality of life of patients post-COVID-19. Physiother. Res. Int. 2023;28(1):e1972. Araújo BTS, Barros AEVR, Nunes DTX, Remígio de Aguiar MI, Mastroianni VW, de Souza JAF, Fernandes J, Campos SL, Brandão DC, Dornelas, de Andrade A. Effects of continuous aerobic training associated with resistance training on maximal and submaximal exercise tolerance, fatigue, and quality of life of patients post-COVID-19. Physiother. Res. Int. 2023;28(1):e1972.
25.
go back to reference Marzuca-Nassr GN, Seron P, Román C, Gálvez M, Navarro R, Latin G, Marileo T, Molina JP, Sepúlveda P, Oliveros MJ. A hybrid exercise-based cardiac rehabilitation program is an effective strategy to improve muscle strength and functional exercise capacity in adults and older people with coronary artery disease. Front Physiol. 2022;13:948273.CrossRefPubMedPubMedCentral Marzuca-Nassr GN, Seron P, Román C, Gálvez M, Navarro R, Latin G, Marileo T, Molina JP, Sepúlveda P, Oliveros MJ. A hybrid exercise-based cardiac rehabilitation program is an effective strategy to improve muscle strength and functional exercise capacity in adults and older people with coronary artery disease. Front Physiol. 2022;13:948273.CrossRefPubMedPubMedCentral
Metadata
Title
A pulmonary rehabilitation program is an effective strategy to improve forced vital capacity, muscle strength, and functional exercise capacity similarly in adults and older people with post-severe COVID-19 who required mechanical ventilation
Authors
Rodrigo Muñoz-Cofré
María Fernanda del Valle
Gabriel Nasri Marzuca-Nassr
Jorge Valenzuela
Mariano del Sol
Constanza Díaz Canales
Pablo A. Lizana
Fernando Valenzuela-Aedo
Rodrigo Lizama-Pérez
Máximo Escobar-Cabello
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2024
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-024-04910-9

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