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BMC Oral Health
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | COVID-19 | Research

Hematologic tests and their association with the severity of COVID-19 and periodontitis in hospitalized patients: a case–control study

Authors: Janet Moradi Haghgoo, Parviz Torkzaban, Maryam Farhadian, Nazli Rabienejad, Sayed Ali Moosavi Sedeh

Published in: BMC Oral Health | Issue 1/2023

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Abstract

Background

The presence of comorbidities, especially those with a chronic inflammatory nature such as periodontitis, can facilitate COVID-19 progression toward more severe forms. Both of these diseases can affect systemic health and alter hematological test results. In this study, we decided to investigate COVID-19 and periodontitis’ possible interaction with these alterations.

Methods

Hospitalized patients with a definitive diagnosis of COVID-19 were included. Controls had mild to moderate COVID-19, while cases had severe to critical COVID-19. Periodontal examination was done for each patient. Relevant medical and hematological data were extracted from patient’s hospital files.

Results

A total of 122 patients entered the final analysis. The minimum white blood cell counts were associated with the severity of periodontitis. The interaction between periodontitis and COVID-19 was associated with increased minimum white blood cell counts and decreased platelet counts. COVID-19 severity was associated with increased venous oxygen saturation, prothrombin time, the maximum partial thromboplastin time, the maximum and average urea, the maximum creatinine, the maximum potassium, and lactate dehydrogenase, and decreased sodium levels.

Conclusions

Results of this study showed that several blood parameters were associated with periodontitis, COVID-19, or the interaction between them.
Literature
1.
2.
Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–42.CrossRefPubMed
3.
Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, and the Northwell C-RC. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020;323(20):2052–9.CrossRefPubMedPubMedCentral
4.
Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontology 2000. 1997;14(1):9–11.CrossRefPubMed
5.
Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer RT, Graziani F, Herrera D, Jepsen S, Lione L, Madianos P. Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. Diabetes Res Clin Pract. 2018;137:231–41.CrossRefPubMed
6.
Ghahramani S, Tabrizi R, Lankarani KB, Kashani SMA, Rezaei S, Zeidi N, Akbari M, Heydari ST, Akbari H, Nowrouzi-Sohrabi P, et al. Laboratory features of severe vs. non-severe COVID-19 patients in Asian populations: a systematic review and meta-analysis. Eur J Med Res. 2020;25(1):30.CrossRefPubMedPubMedCentral
7.
Soraya GV, Ulhaq ZS. Crucial laboratory parameters in COVID-19 diagnosis and prognosis: An updated meta-analysis. Med Clin. 2020;155(4):143–51.CrossRef
8.
Deng X, Liu B, Li J, Zhang J, Zhao Y, Xu K. Blood biochemical characteristics of patients with coronavirus disease 2019 (COVID-19): a systemic review and meta-analysis. Clinical Chemistry and Laboratory Medicine (CCLM). 2020;58(8):1172–81.CrossRefPubMed
9.
Len P, Iskakova G, Sautbayeva Z, Kussanova A, Tauekelova AT, Sugralimova MM, Dautbaeva AS, Abdieva MM, Ponomarev ED, Tikhonov A, et al. Meta-Analysis and Systematic Review of Coagulation Disbalances in COVID-19: 41 Studies and 17,601 Patients. Front Cardiovasc Med. 2022;9:794092.CrossRefPubMedPubMedCentral
10.
Botelho J, Machado V, Hussain SB, Zehra SA, Proença L, Orlandi M, Mendes JJ, D’Aiuto F. Periodontitis and circulating blood cell profiles: a systematic review and meta-analysis. Exp Hematol. 2021;93:1–13.CrossRefPubMed
11.
França LFdC, da Silva FRP, di Lenardo D, Alves EHP, Nascimento HMS, da Silva IAT, Vasconcelos ACCG, Vasconcelos DFP. Comparative analysis of blood parameters of the erythrocyte lineage between patients with chronic periodontitis and healthy patients: Results obtained from a meta-analysis. Arch Oral Biol. 2019;97:144–9.CrossRefPubMed
12.
Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol. 2008;35(4):277–90.CrossRefPubMed
13.
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu N-H, Nitsche A. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–80.CrossRefPubMedPubMedCentral
14.
Wang K, Chen W, Zhou Y-S, Lian J-Q, Zhang Z, Du P, Gong L, Zhang Y, Cui H-Y, Geng J-J, et al. SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. Signal Transduct Target Ther. 2020;5:283.CrossRefPubMedPubMedCentral
15.
Gupta S, Mohindra R, Chauhan PK, Singla V, Goyal K, Sahni V, Gaur R, Verma DK, Ghosh A, Soni RK, et al. SARS-CoV-2 Detection in Gingival Crevicular Fluid. J Dent Res. 2021;100(2):187–93.CrossRefPubMed
16.
Gupta S, Mohindra R, Singla M, Khera S, Sahni V, Kanta P, Soni RK, Kumar A, Gauba K, Goyal K, et al. The clinical association between Periodontitis and COVID-19. Clin Oral Invest. 2022;26(2):1361–74.CrossRef
17.
Marouf N, Cai W, Said KN, Daas H, Diab H, Chinta VR, Hssain AA, Nicolau B, Sanz M, Tamimi F. Association between periodontitis and severity of COVID-19 infection: A case–control study. J Clin Periodontol. 2021;48(4):483–91.CrossRefPubMedPubMedCentral
18.
Anand PS, Jadhav P, Kamath KP, Kumar SR, Vijayalaxmi S, Anil S. A case-control study on the association between periodontitis and coronavirus disease (COVID-19). J Periodontol. 2022;93(4):584–90.CrossRefPubMed
19.
Löe H, Silness J. Periodontal Disease in Pregnancy I. Prevalence and Severity Acta Odontologica Scandinavica. 1963;21(6):533–51.CrossRefPubMed
20.
Mombelli A, van Oosten MAC, Schürch E Jr, Lang NP. The microbiota associated with successful or failing osseointegrated titanium implants. 1987;2(4):145–51.PubMed
21.
Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89(S1):S173–82.CrossRefPubMed
22.
Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Periodontol. 2018;89(S1):S159–72.CrossRefPubMed
23.
Li G, Yang Y, Gao D, Xu Y, Gu J, Liu P. Is liver involvement overestimated in COVID-19 patients? A meta-analysis Int J Med Sci. 2021;18(5):1285–96.CrossRefPubMed
24.
Migliaccio MG, Di Mauro M, Ricciolino R, Spiniello G, Carfora V, Verde N, Mottola FF, Coppola N. Renal Involvement in COVID-19: A Review of the Literature. Infect Drug Resist. 2021;14:895–903.CrossRefPubMedPubMedCentral
25.
Siddiqi HK, Libby P, Ridker PM. COVID-19 - A vascular disease. Trends Cardiovasc Med. 2021;31(1):1–5.CrossRefPubMed
26.
Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, Psaltopoulou T, Gerotziafas G, Dimopoulos MA. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95(7):834–47.CrossRefPubMedPubMedCentral
27.
World Health O. Living guidance for clinical management of COVID-19: living guidance, 23 November 2021. In. Geneva: World Health Organization; 2021.
28.
Han H, Ma Q, Li C, Liu R, Zhao L, Wang W, Zhang P, Liu X, Gao G, Liu F, et al. Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerging Microbes & Infections. 2020;9(1):1123–30.CrossRef
29.
Shimada Y, Komatsu Y, Ikezawa-Suzuki I, Tai H, Sugita N, Yoshie H. The Effect of Periodontal Treatment on Serum Leptin, Interleukin-6, and C-Reactive Protein. J Periodontol. 2010;81(8):1118–23.
30.
Inoue K, Kobayashi Y, Hanamura H, Toyokawa S. Association of periodontitis with increased white blood cell count and blood pressure. Blood Press. 2005;14(1):53–8.CrossRefPubMed
31.
Bordallo B, Bellas M, Cortez AF, Vieira M, Pinheiro M. Severe COVID-19: what have we learned with the immunopathogenesis? Advances in Rheumatology. 2020;60(1):50.CrossRefPubMed
32.
Erez A, Shental O, Tchebiner JZ, Laufer-Perl M, Wasserman A, Sella T, Guzner-Gur H. Diagnostic and prognostic value of very high serum lactate dehydrogenase in admitted medical patients. Isr Med Assoc J. 2014;16(7):439–43.PubMed
33.
Duarte PM, da Rocha M, Sampaio E, Mestnik MJ, Feres M, Figueiredo LC, Bastos MF, Faveri M. Serum Levels of Cytokines in Subjects With Generalized Chronic and Aggressive Periodontitis Before and After Non-Surgical Periodontal Therapy: A Pilot Study. 2010;81(7):1056–63.
34.
Gümüş P, Nizam N, Lappin DF, Buduneli N. Saliva and Serum Levels of B-Cell Activating Factors and Tumor Necrosis Factor-α in Patients With Periodontitis. 2014;85(2):270–80.
35.
Loos BG, Craandijk J, Hoek FJ. Dillen PMEW-v. Van Der Velden U: Elevation of Systemic Markers Related to Cardiovascular Diseases in the Peripheral Blood of Periodontitis Patients. 2000;71(10):1528–34.
36.
Herold T, Jurinovic V, Arnreich C, Lipworth BJ, Hellmuth JC, von Bergwelt-Baildon M, Klein M, Weinberger T. Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19. Journal of Allergy and Clinical Immunology. 2020;146(1):128-136.e124.CrossRefPubMed
37.
Akbari H, Tabrizi R, Lankarani KB, Aria H, Vakili S, Asadian F, Noroozi S, Keshavarz P, Faramarz S. The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. Life Sci. 2020;258: 118167.CrossRefPubMedPubMedCentral
38.
Mulchandani R, Lyngdoh T, Kakkar AK. Deciphering the COVID-19 cytokine storm: Systematic review and meta-analysis. Eur J Clin Invest. 2021;51(1): e13429.CrossRefPubMed
39.
Hajishengallis G. Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications. Periodontology 2000. 2022;89(1):9–18.CrossRefPubMedPubMedCentral
40.
41.
Karagiannidis C, Mostert C, Hentschker C, Voshaar T, Malzahn J, Schillinger G, Klauber J, Janssens U, Marx G, Weber-Carstens S, et al. Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals: an observational study. Lancet Respir Med. 2020;8(9):853–62.CrossRefPubMedPubMedCentral
Metadata
Title
Hematologic tests and their association with the severity of COVID-19 and periodontitis in hospitalized patients: a case–control study
Authors
Janet Moradi Haghgoo
Parviz Torkzaban
Maryam Farhadian
Nazli Rabienejad
Sayed Ali Moosavi Sedeh
Publication date
01-12-2023
Publisher
BioMed Central
Keyword
COVID-19
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-03208-3

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