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01-12-2021 | COVID-19 | Research article

Delirium and other neuropsychiatric manifestations of COVID-19 infection in people with preexisting psychiatric disorders: a systematic review

Authors: Emma A. van Reekum, Tea Rosic, Anjali Sergeant, Nitika Sanger, Myanca Rodrigues, Reid Rebinsky, Balpreet Panesar, Eve Deck, Nayeon Kim, Julia Woo, Alessia D’Elia, Alannah Hillmer, Alexander Dufort, Stephanie Sanger, Lehana Thabane, Lawrence Mbuagbaw, Zainab Samaan

Published in: Journal of Medical Case Reports | Issue 1/2021

Abstract

Background

Psychiatric disorders increase risk of neuropsychiatric disease and poor outcomes, yet little is known about the neuropsychiatric manifestations of COVID-19 in the psychiatric population. The primary objective is to synthesize neuropsychiatric outcomes of COVID-19 in people with preexisting psychiatric disorders.

Methods

Data were collected during an ongoing review of the impact of pandemics on people with existing psychiatric disorders. All study designs and gray literature were included. Medline, PsychInfo, CINAHL, EMBASE, and MedRx were searched from inception to September 1 2020. Risk of bias was assessed using a published tool that can accommodate all study types. Two independent authors screened the studies and extracted data. Data were narratively synthesized, as there were insufficient data to meta-analyze. Evidence was appraised according to GRADE.

Results

Four case reports were included, comprising 13 participants from three countries. Many large-sample, relevant papers were omitted for not reporting psychiatric history, despite reporting other comorbidities. Included participants (n = 13) were hospitalized with COVID-19 and appeared to meet criteria for delirium. Myoclonus, rigidity, and alogia were also reported. The most commonly reported preexisting psychiatric diagnoses were mood disorders, schizophrenia, and alcohol use disorder.

Conclusions

People with preexisting psychiatric disorders may experience delirium, rigidity, myoclonus, and alogia during COVID-19 infection; although higher quality and longitudinal data are needed to better understand these phenomena. Relevant COVID-19 literature does not always report psychiatric history, despite heightened neuropsychiatric vulnerability within this population.

Trial Registration: PROSPERO (CRD42020179611).

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Title: Delirium and other neuropsychiatric manifestations of COVID-19 infection in people with preexisting psychiatric disorders: a systematic review
Authors: Emma A. van Reekum
Tea Rosic
Anjali Sergeant
Nitika Sanger
Myanca Rodrigues
Reid Rebinsky
Balpreet Panesar
Eve Deck
Nayeon Kim
Julia Woo
Alessia D’Elia
Alannah Hillmer
Alexander Dufort
Stephanie Sanger
Lehana Thabane
Lawrence Mbuagbaw
Zainab Samaan
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: COVID-19
Published in: Journal of Medical Case Reports / Issue 1/2021
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-021-03140-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Delirium and other neuropsychiatric manifestations of COVID-19 infection in people with preexisting psychiatric disorders: a systematic review

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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