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01-04-2010 | Original Contribution

Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study

Authors: Jens Richardt Moellegaard Jepsen, Birgitte Fagerlund, Anne Katrine Pagsberg, Anne Marie R. Christensen, Rikke W. Hilker, Merete Nordentoft, Erik L. Mortensen

Published in: European Child & Adolescent Psychiatry | Issue 4/2010

Abstract

Only few prospective longitudinal studies have assessed the course of intelligence deficits in early onset schizophrenia (EOS), and these have used different age appropriate versions of Wechsler Intelligence Scales and age appropriate norms. The post-psychotic development of intelligence in EOS has predominantly been characterized as relatively stable in these studies. However, comparisons of IQs from different test versions based on the different norms may not permit unequivocal interpretations. The objective of the current study was to compare the development of intelligence in EOS patients (N = 10) from their first psychotic episode to 5 years of post onset with that of healthy controls (N = 35) and patients who at baseline had been diagnosed with other non-affective psychoses (N = 8). The same version of a Wechsler Intelligence Scale was administered at both baseline and follow-up assessments, and the same norms were used to derive IQs at baseline and follow-up. Significantly smaller change in mean full scale intelligence quotient (FSIQ) was found in diagnostically stable EOS patients compared with healthy controls during the follow-up period. However, no statistically significant difference in mean FSIQ change was observed between patients with EOS and patients with other non-affective psychoses, although this result must be interpreted with caution due to the small sample sizes. The results suggest abnormally slow acquisition of new intellectual information and skills in EOS patients during the first 5 years after full clinical presentation.

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Title: Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study
Authors: Jens Richardt Moellegaard Jepsen
Birgitte Fagerlund
Anne Katrine Pagsberg
Anne Marie R. Christensen
Rikke W. Hilker
Merete Nordentoft
Erik L. Mortensen
Publication date: 01-04-2010
Publisher: Springer-Verlag
Published in: European Child & Adolescent Psychiatry / Issue 4/2010
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-009-0053-4

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Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study

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