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Published in: Trials 1/2016

Open Access 01-12-2016 | Study protocol

Counteracting Age-related Loss of Skeletal Muscle Mass: a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial

Authors: Rasmus Leidesdorff Bechshøft, Søren Reitelseder, Grith Højfeldt, Josué Leonardo Castro-Mejía, Bekzod Khakimov, Hajar Fauzan Bin Ahmad, Michael Kjær, Søren Balling Engelsen, Susanne Margrete Bølling Johansen, Morten Arendt Rasmussen, Aske Juul Lassen, Tenna Jensen, Nina Beyer, Anja Serena, Frederico Jose Armando Perez-Cueto, Dennis Sandris Nielsen, Astrid Pernille Jespersen, Lars Holm

Published in: Trials | Issue 1/2016

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Abstract

Background

Aging is associated with decreased muscle mass and functional capacity, which in turn decrease quality of life. The number of citizens over the age of 65 years in the Western world will increase by 50 % over the next four decades, and this demographic shift brings forth new challenges at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence to training, thereby attenuating the overall benefits of training. We hypothesize that light load resistance training is more efficient when both adherence and physical improvement are considered longitudinally. We launched the interdisciplinary project on Counteracting Age-related Loss of Skeletal Muscle Mass (CALM) to investigate the impact of lifestyle changes on physical and functional outcomes as well as everyday practices and habits in a qualitative context.

Methods

We will randomize 205 participants older than 65 years to be given 1 year of two daily nutrient supplements with 10 g of sucrose and 20 g of either collagen protein, carbohydrates, or whey. Further, two groups will perform either heavy progressive resistance training or light load training on top of the whey supplement.

Discussion

The primary outcome of the CALM Intervention Study is the change in thigh cross-sectional area. Moreover, we will evaluate changes in physical performance, muscle fiber type and acute anabolic response to whey protein ingestion, sensory adaptation, gut microbiome, and a range of other measures, combined with questionnaires on life quality and qualitative interviews with selected subjects. The CALM Intervention Study will generate scientific evidence and recommendations to counteract age-related loss of skeletal muscle mass in elderly individuals.

Trial registration

ClinicalTrials.gov NCT02034760. Registered on 10 January 2014.
ClinicalTrials.gov NCT02115698. Registered on 14 April 2014.
Danish regional committee of the Capital Region H-4-2013-070. Registered on 4 July 2013.
Danish Data Protection Agency 2012-58-0004 – BBH-2015-001 I-Suite 03432. Registered on 9 January 2015.
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Metadata
Title
Counteracting Age-related Loss of Skeletal Muscle Mass: a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial
Authors
Rasmus Leidesdorff Bechshøft
Søren Reitelseder
Grith Højfeldt
Josué Leonardo Castro-Mejía
Bekzod Khakimov
Hajar Fauzan Bin Ahmad
Michael Kjær
Søren Balling Engelsen
Susanne Margrete Bølling Johansen
Morten Arendt Rasmussen
Aske Juul Lassen
Tenna Jensen
Nina Beyer
Anja Serena
Frederico Jose Armando Perez-Cueto
Dennis Sandris Nielsen
Astrid Pernille Jespersen
Lars Holm
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Trials / Issue 1/2016
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-016-1512-0

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