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Open Access 01-12-2007 | Study protocol

Cost-effectiveness of collaborative care including PST and an antidepressant treatment algorithm for the treatment of major depressive disorder in primary care; a randomised clinical trial

Authors: Marjoliek A IJff, Klaas ML Huijbregts, Harm WJ van Marwijk, Aartjan TF Beekman, Leona Hakkaart-van Roijen, Frans F Rutten, Jürgen Unützer, Christina M van der Feltz-Cornelis

Published in: BMC Health Services Research | Issue 1/2007

Abstract

Background

Depressive disorder is currently one of the most burdensome disorders worldwide. Evidence-based treatments for depressive disorder are already available, but these are used insufficiently, and with less positive results than possible. Earlier research in the USA has shown good results in the treatment of depressive disorder based on a collaborative care approach with Problem Solving Treatment and an antidepressant treatment algorithm, and research in the UK has also shown good results with Problem Solving Treatment. These treatment strategies may also work very well in the Netherlands too, even though health care systems differ between countries.

Methods/design

This study is a two-armed randomised clinical trial, with randomization on patient-level. The aim of the trial is to evaluate the treatment of depressive disorder in primary care in the Netherlands by means of an adapted collaborative care framework, including contracting and adherence-improving strategies, combined with Problem Solving Treatment and antidepressant medication according to a treatment algorithm. Forty general practices will be randomised to either the intervention group or the control group. Included will be patients who are diagnosed with moderate to severe depression, based on DSM-IV criteria, and stratified according to comorbid chronic physical illness. Patients in the intervention group will receive treatment based on the collaborative care approach, and patients in the control group will receive care as usual. Baseline measurements and follow up measures (3, 6, 9 and 12 months) are assessed using questionnaires and an interview. The primary outcome measure is severity of depressive symptoms, according to the PHQ9. Secondary outcome measures are remission as measured with the PHQ9 and the IDS-SR, and cost-effectiveness measured with the TiC-P, the EQ-5D and the SF-36.

Discussion

In this study, an American model to enhance care for patients with a depressive disorder, the collaborative care model, will be evaluated for effectiveness in the primary care setting. If effective across the Atlantic and across different health care systems, it is also likely to be an effective strategy to implement in the treatment of major depressive disorder in the Netherlands.

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Murray CJ, Lopez AD: Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet. 1997, 349: 1498-1504. 10.1016/S0140-6736(96)07492-2.PubMedCrossRef

Bijl RV, Ravelli A, van Zessen G: Prevalence of psychiatric disorder in the general population: results of The Netherlands Mental Health Survey and Incidence Study (NEMESIS). Soc Psychiatry Psychiatr Epidemiol. 1998, 33: 587-595. 10.1007/s001270050098.PubMedCrossRef

De Graaf R, Bijl RV, Spijker J, Beekman ATF, Vollebergh WA: Temporal sequencing of lifetime mood disorders in relation to comorbid anxiety and substance use disorders – findings from the Netherlands Mental Health Survey and Incidence Study. Soc Psychiatry Psychiatr Epidemiol. 2003, 38: 1-11. 10.1007/s00127-003-0597-4.PubMedCrossRef

Ormel J, Bartel M, Nolen WA: [Undertreatment of depression; causes and recommendations. In Dutch]. Ned Tijdschr Geneeskd. 2003, 147: 1005-1009.PubMed

Nutting PA, Rost K, Smith J, Werner JJ, Elliot C: Competing demands from physical problems: effect on initiating and completing depression care over 6 months. Arch Fam Med. 2000, 9: 1059-1064. 10.1001/archfami.9.10.1059.PubMedCrossRef

Deveugele M, Derese A, Brink-Muinen A, Bensing J, de Maeseneer J: Consultation length in general practice: cross sectional study in six European countries. BMJ. 2002, 325: 472-10.1136/bmj.325.7362.472.PubMedPubMedCentralCrossRef

Simon GE, Von Korff M, Piccinelli M, Fullerton C, Ormel J: An international study of the relation between somatic symptoms and depression. N Engl J Med. 1999, 341: 1329-1335. 10.1056/NEJM199910283411801.PubMedCrossRef

De Waal MW, Arnold IA, Eekhof JA, van Hemert AM: Somatoform disorders in general practice: prevalence, functional impairment and comorbidity with anxiety and depressive disorders. Br J Psychiatry. 2004, 184: 470-476. 10.1192/bjp.184.6.470.PubMedCrossRef

Karp JF, Scott J, Houck P, Reynolds CF, Kupfer DJ, Frank E: Pain predicts longer time to remission during treatment of recurrent depression. J Clin Psychiatry. 2005, 66: 591-597.PubMedCrossRef

10.

Kathol RG, Petty F: Relationship of depression to medical illness. A critical review. J Affect Disord. 1981, 3: 111-121. 10.1016/0165-0327(81)90036-7.PubMedCrossRef

11.

Wittchen HU, Lieb R, Wunderlich U, Schuster P: Comorbidity in primary care: presentation and consequences. J Clin Psychiatry. 1999, 60 (Suppl 7): 29-36.PubMed

12.

Mergl R, Seidscheck I, Allgaier AK, Moller HJ, Hegerl U, Henkel V: Depressive, anxiety, and somatoform disorders in primary care: prevalence and recognition. Depress Anxiety. 2006.

13.

Nuyen J, Schellevis FG, Satariano WA, Spreeuwenberg PM, Birkner MD, van den Bos GAM, Groenewegen PP: Comorbidity associated with neurologic and psychiatric diseases: A general practice-based controlled study. J of Clin Epidemiol.

14.

Lustman PJ, Griffith LS, Clouse RE: Depression in Adults with Diabetes. Semin Clin Neuropsychiatry. 1997, 2: 15-23.PubMed

15.

Katon WJ: Clinical and health services relationships between major depression, depressive symptoms, and general medical illness. Biol Psychiatry. 2003, 54: 216-226. 10.1016/S0006-3223(03)00273-7.PubMedCrossRef

16.

Goldney RD, Phillips PJ, Fisher LJ, Wilson DH: Diabetes, depression, and quality of life: a population study. Diabetes Care. 2004, 27: 1066-1070. 10.2337/diacare.27.5.1066.PubMedCrossRef

17.

Cully JA, Graham DP, Stanley MA, Ferguson CJ, Sharafkhaneh A, Souchek J, Kunik ME: Quality of life in patients with chronic obstructive pulmonary disease and comorbid anxiety or depression. Psychosomatics. 2006, 47: 312-319. 10.1176/appi.psy.47.4.312.PubMedCrossRef

18.

Gehi A, Haas D, Pipkin S, Whooley MA: Depression and medication adherence in outpatients with coronary heart disease: findings from the Heart and Soul Study. Arch Intern Med. 2005, 165: 2508-2513. 10.1001/archinte.165.21.2508.PubMedPubMedCentralCrossRef

19.

Ciechanowski PS, Katon WJ, Russo JE: Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch Intern Med. 2000, 160: 3278-3285. 10.1001/archinte.160.21.3278.PubMedCrossRef

20.

Katon WJ, Lin EH, Russo JE, Unutzer J: Increased medical costs of a population-based sample of depressed elderly patients. Arch Gen Psychiatry. 2003, 60: 897-903. 10.1001/archpsyc.60.9.897.PubMedCrossRef

21.

Bodenheimer T: Helping patients improve their health-related behaviors: what system changes do we need?. Dis Manag. 2005, 8: 319-330. 10.1089/dis.2005.8.319.PubMedCrossRef

22.

Schulberg HC, Katon WJ, Simon GE, Rush AJ: Treating major depression in primary care practice: an update of the Agency for Health Care Policy and Research Practice Guidelines. Arch Gen Psychiatry. 1998, 55: 1121-1127. 10.1001/archpsyc.55.12.1121.PubMedCrossRef

23.

Bijl D, van Marwijk HWJ, de Haan M, van Tilburg W, Beekman ATF: Effectiveness of disease management programmes for recognition, diagnosis and treatment of depression in primary care. Eur J Gen Pract. 2004, 10: 6-12.PubMedCrossRef

24.

Van der Feltz-Cornelis CM, van Oppen P, Adèr H, van Dyck R: Randomised Controlled Trial of a Collaborative Care Model with Psychiatric Consultation for Persistent Medically Unexplained Symptoms in General Practice. Psychother Psychosom. 2006, 75: 282-289. 10.1159/000093949.PubMedCrossRef

25.

Schulberg HC: Treating depression in primary care practice: applications of research findings. J Fam Pract. 2001, 50: 535-537.PubMed

26.

Katon WJ, Von Korff M, Lin EH, Simon GE, Walker EA, Unutzer J, Bush T, Russo J, Ludman E: Stepped collaborative care for primary care patients with persistent symptoms of depression: a randomized trial. Arch Gen Psychiatry. 1999, 56: 1109-1115. 10.1001/archpsyc.56.12.1109.PubMedCrossRef

27.

Unutzer J, Katon WJ, Callahan CM, Williams JW, Hunkeler EM, Harpole L, Hoffing M, Della Penna RD, Hitchcock Noël P, Lin EHB, Areán PA, Hegel MT, Tang L, Belin TR, Oishi SM, Langston CA: Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial. JAMA. 2002, 288: 2836-2845. 10.1001/jama.288.22.2836.PubMedCrossRef

28.

Katon WJ, Russo JE, Von Korff M, Lin EH, Simon GE, Bush T, Ludman E, Walker E: Long-term effects of a collaborative care intervention in persistently depressed primary care patients. J Gen Intern Med. 2002, 17: 741-748. 10.1046/j.1525-1497.2002.11051.x.PubMedPubMedCentralCrossRef

29.

Van der Feltz-Cornelis CM, van Oppen P, Adèr H, van Dyck R: [Collaborative care for physically unexplained symptoms in primary care. Results and profits for general practitioners. In Dutch]. Huisarts & Wetenschap. 2006, 49: 342-347.CrossRef

30.

Gilbody S, Bower P, Fletcher J, Richards D, Sutton AJ: Collaborative care for depression: a cumulative meta-analysis and review of longer-term outcomes. Arch Intern Med. 2006, 166: 2314-2321. 10.1001/archinte.166.21.2314.PubMedCrossRef

31.

Bower P, Gilbody S, Richards D, Fletcher J, Sutton A: Collaborative care for depression in primary care: Making sense of a complex intervention: systematic review and meta-regression. Br J Psychiatry. 2006, 189: 484-493. 10.1192/bjp.bp.106.023655.PubMedCrossRef

32.

Unutzer J, Katon WJ, Williams JW, Callahan CM, Harpole L, Hunkeler EM, Hoffing M, Areán PA, Hegel MT, Schoenbaum M, Oishi SM, Langston CA: Improving primary care for depression in late life: the design of a multicenter randomized trial. Med Care. 2001, 39: 785-799. 10.1097/00005650-200108000-00005.PubMedCrossRef

33.

Gensichen J, Beyer M, Muth C, Gerlach FM, Von Korff M, Ormel J: Case management to improve major depression in primary health care: a systematic review. Psychol Med. 2006, 36: 7-14. 10.1017/S0033291705005568.PubMedCrossRef

34.

Mynors-Wallis LM, Gath DH, Day A, Baker F: Randomised controlled trial of problem solving treatment, antidepressant medication, and combined treatment for major depression in primary care. BMJ. 2000, 320: 26-30. 10.1136/bmj.320.7226.26.PubMedPubMedCentralCrossRef

35.

Mynors-Wallis LM, Davies I, Gray A, Barbour F, Gath DH: A randomised controlled trial and cost analysis of problem-solving treatment for emotional disorders given by community nurses in primary care. Br J Psychiatry. 1997, 170: 113-119.PubMedCrossRef

36.

Mynors-Wallis LM, Gath DH, Lloyd-Thomas AR, Tomlinson D: Randomised controlled trial comparing problem solving treatment with amitriptyline and placebo for major depression in primary care. BMJ. 1995, 310: 441-445.PubMedPubMedCentralCrossRef

37.

CBO, Trimbos-instituut: Multidisciplinairy Guideline Depressive disorder [Multidisciplinaire Richtlijn Depressie. In Dutch]. 2005, Utrecht: Trimbos-insituut

38.

Cuijpers P: [In de put, uit de put. Zelf depressiviteit overwinnen. In Dutch]. 2003, Baarn: HB Uitgevers

39.

Cuijpers P, Buijssen H: [Ik zie het weer zitten. Omgaan met depressiviteit/Control your depression. In Dutch]. 1997, Utrecht: Teleac/NOT

40.

Willemse GR, Smit F, Cuijpers P, Tiemens BG: Minimal-contact psychotherapy for sub-threshold depression in primary care. Randomised trial. Br J Psychiatry. 2004, 185: 416-421. 10.1192/bjp.185.5.416.PubMedCrossRef

41.

Vlasveld M, Beekman ATF, Hakkaart-van Roijen L, Hoedeman R, van Marwijk HWJ, van der Feltz-Cornelis CM: The cost-effectiveness of Collaborative Care for Depressive Disorder in the Occupational Health Setting; study protocol of a randomised controlled trial. BMC, article under construction.

42.

Mynors-Wallis LM: Problem-solving treatment in general psychiatric practice. Adv Psych Treatment. 2001, 7: 417-425. 10.1192/apt.7.6.417.CrossRef

43.

Adli M, Berghofer A, Linden M, Helmchen H, Muller-Oerlinghausen B, Mackert A, Stamm T, Bauer M: Effectiveness and feasibility of a standardized stepwise drug treatment regimen algorithm for inpatients with depressive disorders: results of a 2-year observational algorithm study. J Clin Psychiatry. 2002, 63: 782-790.PubMedCrossRef

44.

Bondolfi G, Aubry JM, Golaz J, Gex-Fabry M, Gervasoni N, Bertschy G: A stepwise drug treatment algorithm to obtain complete remission in depression: a Geneva study. Swiss Med Wkly. 2006, 136: 78-85.PubMed

45.

Trivedi MH, Rush AJ, Crismon ML, Kashner TM, Toprac MG, Carmody TJ, Key T, Biggs MM, Shores-Wilson K, Witte B, Suppes T, Miller AL, Altshuler KZ, Shon SP: Clinical results for patients with major depressive disorder in the Texas Medication Algorithm Project. Arch Gen Psychiatry. 2004, 61: 669-680. 10.1001/archpsyc.61.7.669.PubMedCrossRef

46.

Arroll B, Macgillivray S, Ogston S, Reid I, Sullivan F, Williams B, Crombie I: Efficacy and tolerability of tricyclic antidepressants and SSRIs compared with placebo for treatment of depression in primary care: a meta-analysis. Ann Fam Med. 2005, 3: 449-456. 10.1370/afm.349.PubMedPubMedCentralCrossRef

47.

Feinstein AR: Clinical epidemiology: the architecture of clinical research. 1985, Philadelphia: WB Saunders, First

48.

Kroenke K, Spitzer RL, Williams JB: The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001, 16: 606-613. 10.1046/j.1525-1497.2001.016009606.x.PubMedPubMedCentralCrossRef

49.

Van Vliet IM, Leroy H, van Megen HJM: [The MINI-International neuropsychiatric interview: a short, structured, diagnostic interview for DSM-IV and ICD-10 psychiatric disorders. In Dutch]. 2000, Leiden: LUMC

50.

Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC: The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998, 59 (Suppl 20): 22-33.PubMed

51.

Meeuwissen JAC, Donker MCH: [Less is more. Stepped care in mental health care. In Dutch]. Maandblad Geestelijke Volksgezondheid. 2004, 59: 904-915.

52.

Bettinger TL, Crismon ML, Trivedi MH, Grannemann B, Shon SP: Clinicians' adherence to an algorithm for pharmacotherapy of depression in the Texas public mental health sector. Psychiatr Serv. 2004, 55: 703-705. 10.1176/appi.ps.55.6.703.PubMedCrossRef

53.

Van der Feltz-Cornelis CM: Psychiatric consultation for patients with somatoform disorder in general practice. PhD-thesis. 2002, VU Amsterdam

54.

American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders (4th ed. TR). 2000, Washington DC

55.

Oosterhuis A, Klip EC: The treatment of insomnia through mass media, the results of a televised behavioral training programme. Soc Sci Med. 1997, 45: 1223-1229. 10.1016/S0277-9536(97)00041-5.PubMedCrossRef

56.

Jorm AF, Christensen H, Griffiths KM, Rodgers B: Effectiveness of complementary and self-help treatments for depression. Med J Aust. 2002, 176 (Suppl): S84-S96.PubMed

57.

Sontrop J, Campbell MK: Omega-3 polyunsaturated fatty acids and depression: a review of the evidence and a methodological critique. Prev Med. 2006, 42: 4-13. 10.1016/j.ypmed.2005.11.005.PubMedCrossRef

58.

Bosscher RJ: [Runningtherapy in the treatment of Depressive disorder. In Dutch]. PhD-thesis. 1991, VU Amsterdam

59.

Bosmans JE: Cost-effectiveness of treatment of depression in primary care. PhD-thesis. 2006, VU Amsterdam

60.

Lowe B, Unutzer J, Callahan CM, Perkins AJ, Kroenke K: Monitoring depression treatment outcomes with the patient health questionnaire-9. Med Care. 2004, 42: 1194-1201. 10.1097/00005650-200412000-00006.PubMedCrossRef

61.

Hakkaart-van Roijen L: [Manual Trimbos/iMTA questionnaire for costs associated with psychiatric illness. In Dutch]. 2002, Rotterdam: Institute for Medical Technology Assessment

62.

Hakkaart-van Roijen L, Straten van A, Al MJ, Rutten F, Donker M: Cost-utility of brief psychological treatment for depression and anxiety. Br J Psychiatry. 2006, 323-329. 10.1192/bjp.188.4.323.

63.

Euroqol group: Eq-5D user guide. 1995, Rotterdam: Sanders instituut, eur

64.

Ware JE, Sherbourne CD: The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992, 30: 473-483. 10.1097/00005650-199206000-00002.PubMedCrossRef

65.

Hemert AM: [Bodily Complaints Questionnaire. In Dutch]. 2003, Leiden: Leids Universitair Medisch Centrum

66.

Rief W, Hiller W: A new approach to the assessment of the treatment effects of somatoform disorders. Psychosomatics. 2003, 44: 492-498. 10.1176/appi.psy.44.6.492.PubMedCrossRef

67.

Speckens AE, Spinhoven P, Sloekers PP, Bolk JH, van Hemert AM: A validation study of the Whitely Index, the Illness Attitude Scales, and the Somatosensory Amplification Scale in general medical and general practice patients. J Psychosom Res. 1996, 40: 95-104. 10.1016/0022-3999(95)00561-7.PubMedCrossRef

68.

Smets EM, Garssen B, Bonke B, de Haes JC: The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995, 39: 315-325. 10.1016/0022-3999(94)00125-O.PubMedCrossRef

69.

Schneider RA: Reliability and validity of the Multidimensional Fatigue Inventory (MFI-20) and the Rhoten Fatigue Scale among rural cancer outpatients. Cancer Nurs. 1998, 21: 370-373. 10.1097/00002820-199810000-00009.PubMedCrossRef

70.

WHO: Disability Assessment Schedule II (WHO-DAS-II), brief version pilot, interviewer's manual. 1998, Geneva: WHO

71.

Rush AJ, Gullion CM, Basco MR, Jarrett RB, Trivedi MH: The Inventory of Depressive Symptomatology (IDS): psychometric properties. Psychol Med. 1996, 26: 477-486.PubMedCrossRef

72.

Trivedi MH, Rush AJ, Ibrahim HM, Carmody TJ, Biggs MM, Suppes T, Crismon ML, Shores-Wilson K, Toprac MG, Dennehy EB, Witte B, Kashner TM: The Inventory of Depressive Symptomatology, Clinician Rating (IDS-C) and Self-Report (IDS-SR), and the Quick Inventory of Depressive Symptomatology, Clinician Rating (QIDS-C) and Self-Report (QIDS-SR) in public sector patients with mood disorders: a psychometric evaluation. Psychol Med. 2004, 34: 73-82. 10.1017/S0033291703001107.PubMedCrossRef

73.

Van der Feltz-Cornelis CM, van Oppen P, van Marwijk HWJ, de Beurs E, van Dyck R: A patient-doctor relationship questionnaire (PDRQ-9) in primary care: development and psychometric evaluation. Gen Hosp Psychiatry. 2004, 26: 115-120. 10.1016/j.genhosppsych.2003.08.010.PubMedCrossRef

74.

Botega N, Blizard R, Wilkinson DG, Mann A: General practitioners and depression first use of the depression attitude questionnaire. International Journal of Methods for Psychiatric Research. 1992, 4: 169-180.

75.

Holmes TH, Rahe RH: The Social Readjustment Rating Scale. J Psychosom Res. 1967, 11: 213-218. 10.1016/0022-3999(67)90010-4.PubMedCrossRef

76.

Hoekstra HA, de Fruyt F: [NEO-PI-R and NEO-FFI: Big Five Personality-questionnaires: Manual. In Dutch]. 1996, Lisse: Swets & Zeitlinger

77.

Duggan C, Sham P, Lee A, Minne C, Murray R: Neuroticism: a vulnerability marker for depression evidence from a family study. J Affect Disord. 1995, 35: 139-143. 10.1016/0165-0327(95)00062-3.PubMedCrossRef

78.

Oostenbrink JB, Bouwmans CAM, Koopmanschap MA, Rutten FF: [Handleiding voor kostenonderzoek, methoden en standaardkostprijzen voor economische evaluaties in de gezondheidszorg. In Dutch]. 2004, College voor zorgverzekeringen

79.

Van Roijen L, Essink-Bot ML, Koopmanschap MA, Bonsel G, Rutten FF: Labor and health status in economic evaluation of health care. The Health and Labor Questionnaire. Int J Technol Assess Health Care. 1996, 12: 405-415.PubMedCrossRef

80.

Van Dam QD, Spijker A, Arends LR: [Costeffectiveness of psychotherapy: A feasiblity study. In Dutch]. J of Pychotherapy. 1998, 24: 5-22.

81.

Koopmanschap MA, Rutten FF: A practical guide for calculating indirect costs of disease. Pharmacoeconomics. 1996, 10: 460-466.PubMedCrossRef

82.

Koopmanschap MA, Rutten FF, van Ineveld BM, van Roijen L: The friction cost method for measuring indirect costs of disease. J Health Econ. 1995, 14: 171-189. 10.1016/0167-6296(94)00044-5.PubMedCrossRef

83.

Rubin DB: Multiple imputation after 18+ years. J Am Stat Assoc. 1996, 91: 473-489. 10.2307/2291635.CrossRef

84.

Van Hout BA, Al MJ, Gordon GS, Rutten FF: Costs, effects and C/E-ratios alongside a clinical trial. Health Econ. 1994, 3: 309-319.PubMedCrossRef

85.

Adli M, Bauer M, Rush AJ: Algorithms and collaborative-care systems for depression: are they effective and why? A systematic review. Biol Psychiatry. 2006, 59: 1029-1038. 10.1016/j.biopsych.2006.05.010.PubMedCrossRef

86.

Badamgarav E, Weingarten SR, Henning JM, Knight K, Hasselblad V, Gano A, Ofman JJ: Effectiveness of disease management programs in depression: a systematic review. Am J Psychiatry. 2003, 160: 2080-2090. 10.1176/appi.ajp.160.12.2080.PubMedCrossRef

87.

Neumeyer-Gromen A, Lampert T, Stark K, Kallischnigg G: Disease management programs for depression: a systematic review and meta-analysis of randomized controlled trials. Med Care. 2004, 42: 1211-1221. 10.1097/00005650-200412000-00008.PubMedCrossRef

88.

Schrijvers G: Disease management programs in the USA and Europe are comparable (yet?) different. Int J Integr Care. 2006, 6: e13.PubMedPubMedCentral

89.

Unutzer J, Powers D, Katon WJ, Langston CA: From establishing an evidence-based practice to implementation in real-world settings: IMPACT as a case study. Psychiatr Clin North Am. 2005, 28: 1079-1092. 10.1016/j.psc.2005.09.001.PubMedCrossRef

90.

DeRubeis RJ, Hollon SD, Amsterdam JD, Shelton RC, Young PR, Salomon RM, O'Reardon JP, Lovett ML, Gladis MM, Brown LL, Gallop R: Cognitive therapy vs medications in the treatment of moderate to severe depression. Arch Gen Psychiatry. 2005, 62: 409-416. 10.1001/archpsyc.62.4.409.PubMedCrossRef

91.

Hollon SD, Jarrett RB, Nierenberg AA, Thase ME, Trivedi MH, Rush AJ: Psychotherapy and medication in the treatment of adult and geriatric depression: which monotherapy or combined treatment?. J Clin Psychiatry. 2005, 66: 455-468.PubMedCrossRef

92.

Hollon SD, DeRubeis RJ, Shelton RC, Amsterdam JD, Salomon RM, O'Reardon JP, Lovett ML, Young PR, Haman KL, Freeman BB, Gallop S: Prevention of relapse following cognitive therapy vs medications in moderate to severe depression. Arch Gen Psychiatry. 2005, 62: 417-422. 10.1001/archpsyc.62.4.417.PubMedCrossRef

93.

Pampallona S, Bollini P, Tibaldi G, Kupelnick B, Munizza C: Combined pharmacotherapy and psychological treatment for depression: a systematic review. Arch Gen Psychiatry. 2004, 61: 714-719. 10.1001/archpsyc.61.7.714.PubMedCrossRef

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6963/7/34/prepub

Title: Cost-effectiveness of collaborative care including PST and an antidepressant treatment algorithm for the treatment of major depressive disorder in primary care; a randomised clinical trial
Authors: Marjoliek A IJff
Klaas ML Huijbregts
Harm WJ van Marwijk
Aartjan TF Beekman
Leona Hakkaart-van Roijen
Frans F Rutten
Jürgen Unützer
Christina M van der Feltz-Cornelis
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: BMC Health Services Research / Issue 1/2007
Electronic ISSN: 1472-6963
DOI: https://doi.org/10.1186/1472-6963-7-34

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cost-effectiveness of collaborative care including PST and an antidepressant treatment algorithm for the treatment of major depressive disorder in primary care; a randomised clinical trial

Abstract

Background

Methods/design

Discussion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods/design

Discussion

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