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European Journal of Clinical Microbiology & Infectious Diseases

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21-11-2023 | Corynebacterium Diphtheriae | Brief Report

Molecular characterization and whole-genome sequencing of Corynebacterium diphtheriae causing skin lesion

Authors: Juliana Nunes Ramos, Max Roberto Batista Araújo, Lincoln Oliveira Sant’Anna, Sérgio Bokermann, Carlos Henrique Camargo, Fernanda Diniz Prates, Cláudio Tavares Sacchi, Verônica Viana Vieira, Karoline Rodrigues Campos, Marlon Benedito Nascimento Santos, Marcus Vinícius Canário Viana, Vasco Azevedo, Flávia Figueira Aburjaile, Ana Luiza de Mattos-Guaraldi, Louisy Sanches dos Santos

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 1/2024

Abstract

We present a case of skin lesion caused by nontoxigenic Corynebacterium diphtheriae. Genomic taxonomy analyses corroborated the preliminary identification provided by mass spectrometry. The strain showed a susceptible phenotype with increased exposure to penicillin, the first drug of choice for the treatment. An empty type 1 class integron carrying only the sul1 gene, which encodes sulfonamide resistance, was found flanked by transposases. Virulence factors involved in adherence and iron uptake, as well as the CRISPR-Cas system, were predicted. MLST analysis revealed the ST-681, previously reported in French Guiana, a European territory.

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Title: Molecular characterization and whole-genome sequencing of Corynebacterium diphtheriae causing skin lesion
Authors: Juliana Nunes Ramos
Max Roberto Batista Araújo
Lincoln Oliveira Sant’Anna
Sérgio Bokermann
Carlos Henrique Camargo
Fernanda Diniz Prates
Cláudio Tavares Sacchi
Verônica Viana Vieira
Karoline Rodrigues Campos
Marlon Benedito Nascimento Santos
Marcus Vinícius Canário Viana
Vasco Azevedo
Flávia Figueira Aburjaile
Ana Luiza de Mattos-Guaraldi
Louisy Sanches dos Santos
Publication date: 21-11-2023
Publisher: Springer Berlin Heidelberg
Keywords: Corynebacterium Diphtheriae
Diphtheria
Penicillins
Published in: European Journal of Clinical Microbiology & Infectious Diseases / Issue 1/2024
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-023-04706-6

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