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Published in: Diabetology & Metabolic Syndrome 1/2015

Open Access 01-12-2015 | Meeting abstract

Cortistatin hyperpolarizes pancreatic beta cell membrane and reduces glucose-stimulated insulin secretion

Authors: Alex Rafacho, Manuel Castellano-Muñoz, Paloma Alonso-Magdalena, Esperanza Irles, Melisa Bello, Jean Vetorazzi, Beatriz Merino, Sergi Soriano, Pau Iborra, Antonia Ruiz, Raúl M Luque, Angel Nadal, Ivan Quesada

Published in: Diabetology & Metabolic Syndrome | Special Issue 1/2015

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Excerpt

Cortistatin-14 (CORT) is a neuropeptide commonly expressed in inhibitory neurons of the central nervous system (CNS) with structural, pharmacological and functional similarity to somatostatin (SST). In addition to having roles in the CNS, both peptides also regulate endocrine secretion. Yet the cellular mechanisms supporting this role are not well understood. …
Metadata
Title
Cortistatin hyperpolarizes pancreatic beta cell membrane and reduces glucose-stimulated insulin secretion
Authors
Alex Rafacho
Manuel Castellano-Muñoz
Paloma Alonso-Magdalena
Esperanza Irles
Melisa Bello
Jean Vetorazzi
Beatriz Merino
Sergi Soriano
Pau Iborra
Antonia Ruiz
Raúl M Luque
Angel Nadal
Ivan Quesada
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Diabetology & Metabolic Syndrome / Issue Special Issue 1/2015
Electronic ISSN: 1758-5996
DOI
https://doi.org/10.1186/1758-5996-7-S1-A250

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