Published in:
Open Access
01-12-2015 | Meeting abstract
Cortistatin hyperpolarizes pancreatic beta cell membrane and reduces glucose-stimulated insulin secretion
Authors:
Alex Rafacho, Manuel Castellano-Muñoz, Paloma Alonso-Magdalena, Esperanza Irles, Melisa Bello, Jean Vetorazzi, Beatriz Merino, Sergi Soriano, Pau Iborra, Antonia Ruiz, Raúl M Luque, Angel Nadal, Ivan Quesada
Published in:
Diabetology & Metabolic Syndrome
|
Special Issue 1/2015
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Excerpt
Cortistatin-14 (CORT) is a neuropeptide commonly expressed in inhibitory neurons of the central nervous system (CNS) with structural, pharmacological and functional similarity to somatostatin (SST). In addition to having roles in the CNS, both peptides also regulate endocrine secretion. Yet the cellular mechanisms supporting this role are not well understood. …