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Neuroradiology

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01-07-2013 | Functional Neuroradiology

Cortical reorganization after motor imagery training in chronic stroke patients with severe motor impairment: a longitudinal fMRI study

Authors: Limin Sun, Dazhi Yin, Yulian Zhu, Mingxia Fan, Lili Zang, Yi Wu, Jie Jia, Yulong Bai, Bing Zhu, Yongshan Hu

Published in: Neuroradiology | Issue 7/2013

Abstract

Introduction

Despite its clinical efficacy, few studies have examined the neural mechanisms of motor imagery training (MIT) in stroke. Our objective was to find the cortical reorganization patterns after MIT in chronic stroke patients.

Methods

Twenty stroke patients with severe motor deficits were randomly assigned to the MIT or conventional rehabilitation therapy (CRT) group, but two lost in the follow-up. All 18 patients received CRT 5 days/week for 4 weeks. Nine subjects in the MIT group received 30-min MIT 5 days/week for 4 weeks. Before and after the interventions, the upper limb section of the Fugl–Meyer Scale (FM-UL) was blindly evaluated, and functional magnetic resonance imaging was administered while the patients executed a passive fist clutch task.

Results

Two cortical reorganization patterns were found. One pattern consisted of the growth in activation in the contralateral sensorimotor cortex (cSMC) for most patients (six in the MIT group, five in the CRT group), and the other consisted of focusing of the activation in the cSMC with increasing of the laterality index of the SMC for a small portion of patients (three in the MIT group, one in the CRT group). When we applied correlation analyses to the variables of relative ΔcSMC and ΔFM-UL in the 11 patients who experienced the first pattern, a positive relationship was detected.

Conclusions

Our results indicate that different cortical reorganization patterns (increases in or focusing of recruitment to the cSMC region) exist in chronic stroke patients after interventions, and patients may choose efficient patterns to improve their motor function.

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Title: Cortical reorganization after motor imagery training in chronic stroke patients with severe motor impairment: a longitudinal fMRI study
Authors: Limin Sun
Dazhi Yin
Yulian Zhu
Mingxia Fan
Lili Zang
Yi Wu
Jie Jia
Yulong Bai
Bing Zhu
Yongshan Hu
Publication date: 01-07-2013
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 7/2013
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-013-1188-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cortical reorganization after motor imagery training in chronic stroke patients with severe motor impairment: a longitudinal fMRI study

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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