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Dysphagia
Published in: Dysphagia 5/2018

01-10-2018 | Original Article

Correlation of Patient- and Physician-Scored Dysphagia with Videofluoroscopies in Patients Treated with Radiotherapy for Head and Neck Cancer

Authors: D. Nevens, A. Goeleven, F. Duprez, A. Laenen, E. Dejaeger, W. De Neve, S. Nuyts

Published in: Dysphagia | Issue 5/2018

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Abstract

The aim of this study was to investigate the correlation between patient-scored dysphagia and physician-scored dysphagia in head and neck cancer patients treated with radiotherapy. Furthermore, we wanted to compare both patient- and physician-scored dysphagia with dysphagia evaluated on swallowing videofluoroscopies. Sixty-three patients from two different centers treated with radiotherapy for head and neck cancer were evaluated in the current study. Swallowing videofluoroscopies at baseline, 6, and 12 months following radiotherapy were evaluated by 2 observers using the Penetration Aspiration Scale (PAS) and Swallowing Performance Status Scale (SPS) and correlated with patient and physician scored dysphagia. We observed a significant association between physician and patient scored dysphagia (p < 0.01), pre-treatment and post-treatment. Furthermore, the risk of observing dysphagia on videofluoroscopies increased significantly with increasing scores of both physician as well as patient scored dysphagia, and this at all assessed time-points. Patient-scored dysphagia correlates better with dysphagia evaluated by the PAS. Physician-scored dysphagia, however, correlates better with dysphagia as evaluated using the SPS. Both physician- and patient-scored dysphagia correlate well with dysphagia evaluated on videofluoroscopies. Since patient-scored dysphagia correlates better with PAS and changes in the PAS score, and physician-scored dysphagia correlates better with SPS, we advocate to use both patient- and physician-scored dysphagia in future trials.
Literature
1.
2.
Pignon JP, Bourhis J, Domenge C, et al. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analysis of updated individual data. MACH-NC Collaborative Group. Meta-analysis of chemotherapy on head and neck cancer. Lancet. 2000;355:949–55.CrossRefPubMed
3.
Wendt TG, Grabenbauer GG, Rödel CM, et al. Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer: a randomized multicenter study. J Clin Oncol. 1998;16:1318–24.CrossRefPubMed
4.
Bourhis J, Overgaard J, Audry H, et al. Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet. 2006;368:843–54.CrossRefPubMed
5.
Machtay M, Moughan J, Trotti A, et al. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol. 2008;26:3582–9.CrossRefPubMedPubMedCentral
6.
Langendijk JA, Doornaert P, Verdonck-de Leeuw IM, et al. Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy. J Clin Oncol. 2008;26:3770–6.CrossRefPubMed
7.
Langendijk JA, Doornaert P, Rietveld DH, et al. A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer. Radiother Oncol. 2009;90:189–95.CrossRefPubMed
8.
Nevens D, Deschuymer S, Langendijk JA, et al. Validation of the total dysphagia risk score (TDRS) in head and neck cancer patients in a conventional and a partially accelerated radiotherapy scheme. Radiother Oncol. 2016;118(2):293–7.CrossRefPubMed
9.
10.
Jensen K, Bonde Jensen A, Grau C. The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system and the EORTC quality of life questionnaires. Radiother Oncol. 2006;78(3):298–305.CrossRefPubMed
11.
Florie M, Baijens L, Kremer B, et al. Relationship between swallow-specific quality of life and fiber-optic endoscopic evaluation of swallowing findings in patients with head and neck cancer. Head Neck. 2016;38(Suppl 1):E1848–56.CrossRefPubMed
12.
Kendall KA, Kosek SR, Tanner K. Quality-of-life scores compared to objective measures of swallowing after oropharyngeal chemoradiation. Laryngoscope. 2014;124(3):682–7.CrossRefPubMed
13.
Pauloski BR, Rademaker AW, Logemann JA, et al. Swallow function and perception of dysphagia in patients with head and neck cancer. Head Neck. 2002;24(6):555–6.CrossRefPubMed
14.
Nuyts S, Lambrecht M, Duprez F, et al. Reduction of the dose to the elective neck in head and neck squamous cell carcinoma, a randomized clinical trial using intensity modulated radiotherapy (IMRT). Dosimetrical analysis and effect on acute toxicity. Radiother Oncol. 2013;109(2):323–9.CrossRefPubMed
15.
Nevens D, Duprez F, Daisne JF, et al. Reduction of the dose of radiotherapy to the elective neck in head and neck squamous cell carcinoma; a randomized clinical trial. Effect on late toxicity and tumor control. Radiother Oncol. 2017;122(2):171–7.CrossRefPubMed
16.
Karnofsky DA, Burchenal JH. The clinical evaluation of chemotherapeutic agents in cancer. In: MacLeod CM, editor. evaluation of chemotherapeutic agents. Columbia: Columbia University Press; 1949. p. 196.
17.
Rosenbek JC, Robbins JA, Roecker EB, Coyle JL, Wood JL. A penetration-aspiration scale. Dysphagia. 1996;11(2):93–8.CrossRefPubMed
18.
Karnell MP, MacCracken E. A database information storage and reporting system for videofluorographic oropharyngeal motility (OPM) swallowing evaluations. Am J Speech Lang Pathol. 1994;3:354–60.CrossRef
19.
Singer S, Araújo C, Arraras JI, on behalf of the EORTC Quality of Life and the EORTC Head and Neck Cancer Groups, et al. Measuring quality of life in patients with head and neck cancer: update of the EORTC QLQ-H&N Module, Phase III. Head Neck. 2015;37:1358–67.CrossRefPubMed
20.
Raber-Durlacher JE, Brennan MT, Verdonck-de Leeuw IM, et al. Dysphagia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO). Swallowing dysfunction in cancer patients. Support Care Cancer. 2012;20(3):433–43.CrossRefPubMed
21.
Shrout P, Fleiss J. Intraclass correlations: uses in assessing rater reliability. Psychol Bull. 1979;86(2):420–8.CrossRefPubMed
22.
Akaike, H. Information theory and an extension of the maximum likelihood principle. In: Petrov, B; Csáki, F, 2nd International Symposium on Information Theory, Tsahkadsor, Armenia, USSR, September 2–8, 1971, Budapest: Akadémiai Kiadó, pp. 267–281.
23.
Scott N, Fayers P, Bottomley A. EORTC QLQ-C30 Reference values manual. Brussels: EORTC Quality of Life Group Publications; 2008.
24.
Stenson KM, MacCracken E, List M, et al. Swallowing function in patients with head and neck cancer prior to treatment. Arch Otolaryngol Head Neck Surg. 2000;126:371–7.CrossRefPubMed
25.
Rosenbek JC, Robbins JA, Roecker EB, et al. A penetration-aspiration scale. Dysphagia. 1996;11:93–8.CrossRefPubMed
26.
Jaiprakash A, Vijay P, Debnarayan D, et al. Objective assessment of swallowing function after definitive concurrent (chemo)radiotherapy in patients with head and neck cancer. Dysphagia. 2011;26:399–406.CrossRef
27.
Colodny N. Interjudge and intrajudge reliabilities in fiberoptic endoscopic evaluation of swallowing (Fees®) using the penetration–aspiration scale: a replication study. Dysphagia. 2002;17:308–15.CrossRefPubMed
28.
Starmer HM, Quon H, Kumar R, et al. The effect of radiation dose on swallowing: evaluation of aspiration and kinematics. Dysphagia. 2015;30:430–7.CrossRefPubMed
29.
Shune SE, Karnell LH, Karnell MP, Van Daele DJ, Funk GF. Association between severity of dysphagia and survival in patients with head and neck cancer. Head Neck. 2012;34(6):776–84.CrossRefPubMed
30.
Landis J, Koch G. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74.CrossRefPubMed
31.
Hutcheson KA, Barrow MP, Barringer DA, et al. Dynamic Imaging Grade of Swallowing Toxicity (DIGEST): scale development and validation. Cancer. 2017;123(1):62–70.CrossRefPubMed
Metadata
Title
Correlation of Patient- and Physician-Scored Dysphagia with Videofluoroscopies in Patients Treated with Radiotherapy for Head and Neck Cancer
Authors
D. Nevens
A. Goeleven
F. Duprez
A. Laenen
E. Dejaeger
W. De Neve
S. Nuyts
Publication date
01-10-2018
Publisher
Springer US
Published in
Dysphagia / Issue 5/2018
Print ISSN: 0179-051X
Electronic ISSN: 1432-0460
DOI
https://doi.org/10.1007/s00455-018-9888-5

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